INNOVABONE
Novel biomimetic strategy for bone regeneration
| Coordinatore | UNIVERSITAT WIEN
Organization address
address: UNIVERSITATSRING 1 contact info |
| Nazionalità Coordinatore | Austria [AT] |
| Totale costo | 8˙015˙252 € |
| EC contributo | 6˙199˙649 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2010-LARGE-4 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-11-01 - 2015-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITAT WIEN
Organization address
address: UNIVERSITATSRING 1 contact info |
AT (WIEN) | coordinator | 1˙152˙873.00 |
| 2 |
MEDIZINISCHE UNIVERSITAET WIEN
Organization address
address: SPITALGASSE 23 contact info |
AT (WIEN) | participant | 769˙033.00 |
| 3 |
CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT
Organization address
address: RUE JAQUET DROZ 1 contact info |
CH (NEUCHATEL) | participant | 728˙233.00 |
| 4 |
THE UNIVERSITY OF NOTTINGHAM
Organization address
address: University Park contact info |
UK (NOTTINGHAM) | participant | 581˙075.00 |
| 5 |
Nome Ente NON disponibile
Organization address
address: Rosenhof 1 contact info |
DE (Heilbad Heiligenstadt) | participant | 559˙739.00 |
| 6 |
UNIVERSIDAD DE VALLADOLID
Organization address
address: PLAZA SANTA CRUZ 8 PALACIO DE SANTA CRUZ contact info |
ES (VALLADOLID) | participant | 449˙040.00 |
| 7 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | participant | 435˙746.00 |
| 8 |
TETRA GESELLSCHAFT FUR SENSORIK ROBOTIK UND AUTOMATION MBH
Organization address
address: GEWERBEPARK AM WALD 4 contact info |
DE (ILMENAU) | participant | 346˙660.00 |
| 9 |
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Organization address
address: Robert-Koch-Strasse 40 contact info |
DE (GOETTINGEN) | participant | 344˙693.00 |
| 10 |
UNIVERSITAT POLITECNICA DE CATALUNYA
Organization address
address: Jordi Girona 31 contact info |
ES (BARCELONA) | participant | 243˙857.00 |
| 11 |
Promoscience srl
Organization address
address: LOCALITA PADRICIANO 99 contact info |
IT (TRIESTE) | participant | 231˙520.00 |
| 12 |
MOVERIM CONSULTING SPRL
Organization address
address: SQUARE AMBIORIX 32 contact info |
BE (BRUXELLES) | participant | 148˙800.00 |
| 13 |
Qserve Consultancy BV
Organization address
address: Gordel van Smaragd 23 contact info |
NL (Purmerend) | participant | 104˙550.00 |
| 14 |
BAXTER INNOVATIONS GMBH
Organization address
address: INDUSTRIESTRASSE 67 contact info |
AT (WIEN) | participant | 103˙830.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'The importance of developing novel approaches for bone repair is underscored by the heavy burden on health care costs and patient suffering caused by traumatic, osteoporotic and osteolytic metastatic bone lesions. To address these health challenges, we will develop optimally performing bioinspired biomaterials mimicking the natural physiological processes underlying bone repair. Our overall approach is to produce smart bioactive 3D scaffolds to fit within bone lesions, which we will then inject with functional, genetically-engineered self-solidifying elastin-like polymers with absolute-controlled molecular architecture and sequences containing specific domains for cell attachment, growth factors and calcium phosphate nanoparticles. The resulting bioactive, biodegradable scaffolds, biogels and regenerated bone will be analysed for biomaterial effects on bone growth, healing, foreign body reactions using cutting-edge in vitro assays, BioMEMS technology, in vivo animal models, non-invasive imaging and gene expression profiling for discovery of biomarkers associated with bone repair. Biomaterials will also be tested with biodynamic assays to assess strength, durability, toxicology, sterilisation reaction, eco-toxicology and risk assessment. Our multidisciplinary consortium with its extensive, state-of-the-art expertise consisting of private and public partners, cellular and molecular biologists, immunologists, physicists, bioengineers, and orthopaedic surgeons will tackle serious bone lesions with a comprehensive work plan to develop a prototype, evaluate it in vivo and in vitro, upscale its production and prepare the final material for clinical phase trials and commercialisation of the dual component product. Our ultimate aims are to ensure strong, healthy bone regeneration, reduce pain and suffering and to become a competitor in the biomaterials market of Europe.'
Introduzione (Teaser)
A multidisciplinary European research project is following nature's recipe to repair bone.