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CTC-MAL

Isolation of rare circulating tumor cells

Total Cost €

EC-Contrib. €

Partnership

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CTC-MAL project word cloud

Explore the words cloud of the CTC-MAL project. It provides you a very rough idea of what is the project "CTC-MAL" about.

csa cells isolate ctcs molecule stage types company grant lines primary unprecedented methodology protein monitor direct uniformly pursue escaping recombinant sensitivity form establishment consolidator implications distinguish normal settle treatment rvar2 specificity ctc prognostic diverse preliminary isolation distant strategic efficacy individual awarded blood provides molecular rare migration cancer biopsies circulating prepare expressed 2013 phenotypic diagnosis tool capacity separate malaria personalized tumor plan hundreds sharpen patients metastasis cancers basic organs invasive erc pivotal data verified tissue binds opportunity 1ml themselves medicine grantee poc thousands guide prognosis drug cell characterization pr validate attractive

Project "CTC-MAL" data sheet

The following table provides information about the project.

Coordinator	KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Total cost	149˙375 €
EC max contribution	149˙375 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2018
Duration (year-month-day)	from 2018-02-01 to 2019-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	coordinator	149˙375.00

Map

Project objective

In 2013 I was awarded an ERC consolidator grant to pursue a novel cancer targeting concept using a recombinant malaria protein. As an ERC grantee I verified the malaria protein (rVAR2) binds to this distinct cancer expressed molecule (CSA) in hundreds of cancer cell lines and thousands of tissue biopsies. Our research demonstrate a pivotal role of CSA in cancer cell migration and thus in the formation of metastasis. Circulating tumor cells (CTCs) are cancer cells escaping the primary tumor with the capacity to settle and form a metastasis in distant organs. Isolation of CTC is thus a very attractive non-invasive measure of the stage of a given cancer and provides the opportunity to do direct phenotypic analyses. However CTCs are in most cases very rare (10 cells pr 1ml blood) and does not uniformly distinguish themselves from normal blood cells. Our preliminary data show that rVAR2 very effectively can be used to isolate CTCs from diverse types of cancer with unprecedented specificity and sensitivity. Such a tool could have wide impact for cancer patients because it could sharpen diagnosis, increase prognostic ability, monitor drug efficacy and facilitate molecular characterization of individual cancers with implications for personalized medicine and basic cancer research. The aim of the ERC PoC project is to A) prepare for establishment of a separate company with a strategic product plan and B) further develop and validate the methodology enabling diagnosis, prognosis and guide treatment.

Publications

List of publications.
year	authors and title	journal	last update
2018	Mette Ã˜. AgerbÃ¦k, Sara R. Bang-Christensen, Ming-Hsin Yang, Thomas M. Clausen, Marina A. Pereira, Shreya Sharma, Sisse B. Ditlev, Morten A. Nielsen, Swati Choudhary, Tobias Gustavsson, Poul H. Sorensen, Tim Meyer, David Propper, Jonathan Shamash, Thor G. Theander, Alexandra Aicher, Mads Daugaard, Christopher Heeschen, Ali Salanti The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05793-2	Nature Communications 9/1	2019-10-28

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