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SMART-DNA SIGNED

Single Molecule Analytical Raman Tools based on DNA nanostructures

Total Cost €

EC-Contrib. €

Partnership

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SMART-DNA project word cloud

Explore the words cloud of the SMART-DNA project. It provides you a very rough idea of what is the project "SMART-DNA" about.

single chemistry quantitative apart subpopulations ensemble bio time precision place radiation sufficient electrophilic photothermal surface molecular attractive nanometer excitation origami electron highest enhancement mechanisms modified artificial enhanced plasmonic aptamers specificity effect localized nanoscale plasmonically scattering metallic nanostructures therapy resonance electrons heating distance placed gaps plasmon smart precisely dna transfer strategies molecules dissociation sensitivity conformational reaction positions molecule possibly structural detect nanoparticles spectra electromagnetic cancer reactions monitoring unrivalled chemical assemble raman intermediates promises therapies sers hot sufficiently diffusion premature sm technique

Project "SMART-DNA" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAET POTSDAM Organization address address: AM NEUEN PALAIS 10 city: POTSDAM postcode: 14469 website: www.uni-potsdam.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	1˙996˙476 €
EC max contribution	1˙996˙476 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-COG
Funding Scheme	ERC-COG
Starting year	2018
Duration (year-month-day)	from 2018-04-01 to 2023-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAET POTSDAM UNIVERSITAET POTSDAM Organization address address: AM NEUEN PALAIS 10 city: POTSDAM postcode: 14469 website: www.uni-potsdam.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (POTSDAM)	coordinator	1˙996˙476.00

Map

Project objective

The monitoring of single molecule reactions promises unrivalled insight into chemical reaction mechanisms, but represents one of the most challenging tasks in chemistry. Surface-enhanced Raman scattering (SERS) is a particularly attractive single molecule (SM) technique due to its high chemical specificity, which allows to directly detect relevant intermediates and molecular subpopulations. However, SM-SERS is still at a premature state due to the highly challenging task to place single molecules precisely in nanoscale gaps of plasmonic nanostructures. These are required to provide sufficiently high electromagnetic field enhancement to reach SM sensitivity. The aim of SMART-DNA is to exploit artificial DNA nanostructures to provide sufficient structural control to assemble both, nanoparticles and target molecules, with nanometer precision. By means of novel DNA origami nanostructures the distance between two nanoparticles will be controlled, and at the same time target molecules will be placed at the positions of highest Raman enhancement through DNA aptamers. Apart from Raman enhancement the excitation of the localized surface plasmon resonance of the metallic nanostructures results in other plasmonic effects such as heating and possibly the transfer of hot electrons. This can lead to diffusion, conformational changes or even dissociation of the target molecules. These issues do not only concern SM-SERS, but also make quantitative SERS and the SERS analysis of complex (bio)molecules very challenging. By the improved structural control achieved by SMART-DNA, nanoscale heating and hot electron transfer and their effect on SERS spectra will be studied on an ensemble and a SM level. Finally, reactions induced by plasmonically generated electrons in DNA and DNA modified with electrophilic molecules will be studied by SERS with the aim to develop novel strategies to improve cancer radiation therapies such as the photothermal therapy.

Publications

List of publications.
year	authors and title	journal	last update
2019	Robin SchÃ¼rmann, Kenny Ebel, Christophe Nicolas, Aleksandar R. MilosavljeviÄ‡, Ilko Bald Role of Valence Band States and Plasmonic Enhancement in Electron-Transfer-Induced Transformation of Nitrothiophenol published pages: 3153-3158, ISSN: 1948-7185, DOI: 10.1021/acs.jpclett.9b00848	The Journal of Physical Chemistry Letters 10/11	2019-11-18
2019	Christian Heck, Yael Michaeli, Ilko Bald, Yuval Ebenstein Analytical epigenetics: single-molecule optical detection of DNA and histone modifications published pages: 151-158, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2018.09.006	Current Opinion in Biotechnology 55	2019-11-18
2019	Christian Heck, Yuya Kanehira, Janina Kneipp, Ilko Bald Amorphous Carbon Generation as a Photocatalytic Reaction on DNA-Assembled Gold and Silver Nanostructures published pages: 2324, ISSN: 1420-3049, DOI: 10.3390/molecules24122324	Molecules 24/12	2019-11-18
2019	Youngeun Choi, Carsten Schmidt, Philip Tinnefeld, Ilko Bald, Stefan RÃ¶diger A new reporter design based on DNA origami nanostructures for quantification of short oligonucleotides using microbeads published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41136-x	Scientific Reports 9/1	2019-11-18

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