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CIRCOMMUNICATION SIGNED

Deciphering molecular pathways of circadian clock communication

Total Cost €

EC-Contrib. €

Partnership

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CIRCOMMUNICATION project word cloud

Explore the words cloud of the CIRCOMMUNICATION project. It provides you a very rough idea of what is the project "CIRCOMMUNICATION" about.

biology unravel consists edge elucidate dioxide orchestrate tissue nature body fundamental tick communicate anticipate alongside subsidiary demands harmony mechanisms gases regarding animal setup organs interdisciplinary clocks physiological individual rudimentary cutting environmental ph mammalian shed critical restoring unprecedented network biochemical intricate function master time integrative cue blood points molecular sequentially view continuous behavior primarily timing synchronization carbon animals culture tissues clock physiology overarching reconstruct resetting light moving rhythms extends unison brain cells circadian billions daily signals rhythmic communication almost involvement bears multiple temporal serves oxygen levels obtain cell oscillators peripheral

Project "CIRCOMMUNICATION" data sheet

The following table provides information about the project.

Coordinator	WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Total cost	1˙999˙945 €
EC max contribution	1˙999˙945 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-COG
Funding Scheme	ERC-COG
Starting year	2018
Duration (year-month-day)	from 2018-03-01 to 2023-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	coordinator	1˙999˙945.00

Map

Project objective

The overarching objective of this interdisciplinary project is to elucidate mechanisms through which billions of individual clocks in the body communicate with each other and tick in harmony. The mammalian circadian timing system consists of a master clock in the brain and subsidiary oscillators in almost every cell of the body. Since these clocks anticipate environmental changes and function together to orchestrate daily physiology and behavior their temporal synchronization is critical. Our recent finding that oxygen serves as a resetting cue for circadian clocks points towards the unprecedented involvement of blood gases as time signals. We will apply cutting edge continuous physiological measurements in freely moving animals, alongside biochemical/molecular biology approaches and advanced cell culture setup to determine the molecular role of oxygen, carbon dioxide and pH in circadian clock communication and function. The intricate nature of the mammalian circadian system demands the presence of communication mechanisms between clocks throughout the body at multiple levels. While previous studies primarily addressed the role of the master clock in resetting peripheral clocks, our knowledge regarding the communication among clocks between and within peripheral organs is rudimentary. We will reconstruct the mammalian circadian system from the bottom up, sequentially restoring clocks in peripheral tissues of a non-rhythmic animal to (i) obtain a system-view of the peripheral circadian communication network; and (ii) study novel tissue-derived circadian communication mechanisms. This integrative proposal addresses fundamental aspects of circadian biology. It is expected to unravel the circadian communication network and shed light on how billions of clocks in the body function in unison. Its impact extends beyond circadian rhythms and bears great potential for research on communication between cells/tissues in various fields of biology.

Publications

List of publications.
year	authors and title	journal	last update
2019	Yaarit Adamovich, Benjamin Ladeuix, Jonathan Sobel, Gal Manella, Adi Neufeld-Cohen, Mohammad H. Assadi, Marina Golik, Yael Kuperman, Ariel Tarasiuk, Maarten P. Koeners, Gad Asher Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals published pages: 1092-1103.e3, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2019.01.007	Cell Metabolism 29/5	2019-10-10
2019	Saar Ezagouri, Ziv Zwighaft, Jonathan Sobel, SÃ©bastien Baillieul, StÃ©phane Doutreleau, Benjamin Ladeuix, Marina Golik, Samuel Verges, Gad Asher Physiological and Molecular Dissection of Daily Variance in Exercise Capacity published pages: 78-91.e4, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2019.03.012	Cell Metabolism 30/1	2019-10-10

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