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ForceMorph SIGNED

The integration of cell signalling and mechanical forces in vascular morphology

Total Cost €

EC-Contrib. €

Partnership

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ForceMorph project word cloud

Explore the words cloud of the ForceMorph project. It provides you a very rough idea of what is the project "ForceMorph" about.

cells integrates regulation remodelling vitro tissue recapitulates 4d arterial rationally vascular biomimetic 21st interdisciplinary structural homeostasis hemodynamic time vivo vsmc muscle ec vasculature malformation blood prevent resolution reproducible complexity integrate model mechanosensitivity ecs endothelial signalling artery reflect organisation notch treat tools interactions offers validate conditions regulates biology cell responsibly medical diseases animal treatment wall defects worldwide engineering therapies principal lack computational elucidate imbalance smooth composition forces morphology flow handles cardiovascular vsmcs predict models mechanical physiological question chip therapeutic century

Project "ForceMorph" data sheet

The following table provides information about the project.

Coordinator	ABO AKADEMI Organization address address: DOMKYRKOTORGET 3 city: ABO postcode: 20500 website: http://www.abo.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Finland [FI]
Total cost	1˙919˙599 €
EC max contribution	1˙919˙599 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-COG
Funding Scheme	ERC-COG
Starting year	2018
Duration (year-month-day)	from 2018-03-01 to 2023-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ABO AKADEMI ABO AKADEMI Organization address address: DOMKYRKOTORGET 3 city: ABO postcode: 20500 website: http://www.abo.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (ABO)	coordinator	1˙037˙012.00
2	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	participant	882˙586.00

Map

Project objective

Cardiovascular diseases represent the principal worldwide medical challenge of the 21st century (WHO), and new concepts to treat, predict and even prevent these diseases are needed. Structural remodelling of the vasculature in response to changes in blood flow is important to maintain mechanical homeostasis, and many diseases are related to defects in tissue morphology and mechanical imbalance. Signalling between endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) via the Notch pathway regulates the morphology and structural remodelling of the arterial wall. Importantly, Notch offers handles for therapeutic control and thus opportunities for treatment of malformation and adaptation. However, we lack the essential understanding of how hemodynamic forces integrate with Notch signalling to rationally and responsibly target Notch in vascular therapies. The complexity of the problem requires new tools and an interdisciplinary approach. Our project integrates engineering, computational modelling, with cell biology and in vivo model systems to address the question. In vivo models will validate the in in vitro model systems to ensure that they are reproducible and reflect the reality. Through this integrated approach we will enable new therapeutic developments.

The specific objectives of the project are to:

1) Study EC-VSMC signalling real time, at high resolution by a novel biomimetic 4D Artery-on-Chip that recapitulates the cell-composition, -organisation and hemodynamic forces of the physiological artery

2) Develop a computational model of the arterial wall that include the mechanosensitivity of Notch signalling to predict how the complex interactions affect arterial morphology and remodelling

3) Use in vivo animal models to elucidate how regulation of Notch signalling affects tissue morphology and remodelling in response to changes in hemodynamic conditions

Deliverables

List of deliverables.
Data management plan	Open Research Data Pilot	2019-11-18 10:14:50

Take a look to the deliverables list in detail: detailed list of ForceMorph deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Nicole C. A. van Engeland, Freddy Suarez Rodriguez, Adolfo Rivero-MÃ¼ller, Tommaso Ristori, Camille L. Duran, Oscar M. J. A. Stassen, Daniel Antfolk, Rob C. H. Driessen, Saku Ruohonen, Suvi T. Ruohonen, Salla Nuutinen, Eriika Savontaus, Sandra Loerakker, Kayla J. Bayless, Marika SjÃ¶qvist, Carlijn V. C. Bouten, John E. Eriksson, Cecilia M. Sahlgren Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-48218-w	Scientific Reports 9/1	2019-10-14
2018	L. A. Tiemeijer, J-P. Frimat, O. M. J. A. Stassen, C. V. C. Bouten, C. M. Sahlgren Spatial patterning of the Notch ligand Dll4 controls endothelial sprouting in vitro published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-24646-y	Scientific Reports 8/1	2019-05-08
2018	Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren Mechanosensitivity of Jaggedâ€“Notch signaling can induce a switch-type behavior in vascular homeostasis published pages: E3682-E3691, ISSN: 0027-8424, DOI: 10.1073/pnas.1715277115	Proceedings of the National Academy of Sciences 115/16	2019-09-13
2018	Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren Mechanosensitivity of Jaggedâ€“Notch signaling can induce a switch-type behavior in vascular homeostasis published pages: E3682-E3691, ISSN: 0027-8424, DOI: 10.1073/pnas.1715277115	Proceedings of the National Academy of Sciences 115/16	2019-05-08

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