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ToCCaTa SIGNED

Tailoring the functional Capacity of Cytotoxic T cells for future Therapies

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ToCCaTa project word cloud

Explore the words cloud of the ToCCaTa project. It provides you a very rough idea of what is the project "ToCCaTa" about.

therapeutic    instance    experimental    diversity    treating    seek    systematic    customized    significantly    induction    hypothesis    advantage    disease    equally    memory    function    mimic    immunotherapies    contrasting    strategies    vital    foundation    obstacle    immunity    overcome    similarly    hypo    equipped    expression    translate    tumor    mechanisms    optimized    pathogen    infections    malignant    combination    enormous    acute    anti    fulfil    aggressive    thought    generation    discovery    autoimmunity    cytotoxic    cell    interventional    proliferative    cd8    safe    vaccine    anticipate    immunotherapy    activated    immunopathology    gene    tissue    resting    qualitative    pleiotropic    cells    functions    limited    adjusted    functional    fulminant    resident    lung    augment    single    liver    optimize    effector    stage    phenotypes    attenuate    viral    exhausted    diseases    supporting    chronic    alter    capacity    particularities    utilizing    interventions    molecular    prophylactic    tumors    of    performing    protection    comprehension    screening    solutions   

Project "ToCCaTa" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET MUENCHEN 

Organization address
address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333
website: www.tu-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙850 €
 EC max contribution 1˙999˙850 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙999˙850.00

Map

 Project objective

Cytotoxic T cells have enormous potential for prophylactic and therapeutic interventions against problematic acute or chronic infections and against malignant tumors. A major obstacle to utilizing them effectively is our limited understanding of the molecular foundation that is necessary for CD8 T cells to fulfil their pleiotropic functions. Equally important is to find solutions supporting the robust and safe induction of large numbers of pathogen- or tumor-specific T cells and strategies for customized generation of T cells equipped with a functional capacity that are optimized to the often contrasting needs of particular diseases. For instance, anti-tumor immunity requires large numbers of highly activated effector T cells, while resting memory cells with high proliferative potential in combination with tissue-resident memory cells are thought to enhance protection against viral infections. Similarly, the challenge in treating chronic infections and tumors is to overcome the hypo-functional “exhausted” stage of T cells, but therapeutic induction of the same mechanisms to attenuate an aggressive T cell response could be vital for treating autoimmunity or immunopathology in fulminant liver or lung infections. Thus, to develop prophylactic or interventional strategies through which qualitative aspects of T cell function can be adjusted is a current key challenge in the immunotherapy and vaccine field. We seek to promote such activities by performing research that aims to significantly augment our comprehension of how molecular particularities translate into functional diversity. By taking advantage of 1) experimental systems that specifically mimic disease relevant T cell phenotypes, 2) approaches to assess molecular diversity at single cell level, 3) effective strategies to alter gene expression, and 4) systematic and hypothesis-driven molecular screening, we anticipate the discovery of new targets to optimize immunotherapies for tumors and chronic infections.

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The information about "TOCCATA" are provided by the European Opendata Portal: CORDIS opendata.

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