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SYNFOS

Synthetic toolkit for fragment oriented synthesis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SYNFOS project word cloud

Explore the words cloud of the SYNFOS project. It provides you a very rough idea of what is the project "SYNFOS" about.

ray    diamond    building    potent    secondments    medicinal    showcase    unmet    train    hits    elaborated    co    crystallography    multidisciplinary    uneven    drugs    nelson    direct    biology    adam    medicinally    supervisor    facilitates    fragment    tend    yielding    discover    inhibitors    compounds    fellowship    throughput    tends    university    leader    heterocycles    interaction    toolbox    marsden    chemistry    protein    molecular    ppis    elaboration    ligand    trindade    catalysis    steve    strategy    medical    firstly    carbons    synthetic    hydridised    reactivity    host    synthesised    leeds    mainstream    fragments    discovery    remarkable    flatter    exploration    expertise    fellow    bonds    group    cutting    lipophilic    de    synfos    treatment    laboratory    edge    academic    join    explore    toolkit    functionalization    professors    groups    sp3    atad2    alexandre    space    inhibition    bromodomain    fbld    chemical    exacerbate    advantageous    modes    novo    secondly    independent    interactions    prospects    heterocyclic    despite   

Project "SYNFOS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.asn.leeds.ac.uk/view_person
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00

Map

 Project objective

Fragment-based ligand discovery (FBLD) has become a mainstream strategy to discover new drugs to enable the treatment of conditions with unmet medical needs. Despite the remarkable rise of FBLD, significant chemical challenges remain in the field; firstly, elaborated fragments tend to be synthesised de novo when direct growth would be much more advantageous. Secondly, the currently available toolkit for fragment elaboration tends to exacerbate an uneven exploration of chemical space, yielding flatter and more lipophilic compounds.

SYNFOS will allow Alexandre Trindade (the fellow) to join the laboratory of Professors Adam Nelson (host supervisor) and Steve Marsden (host co-supervisor) at the University of Leeds (Host) and develop research expertise in fragment-based ligand discovery; catalysis to enable molecular discovery; protein-protein interaction (PPIs) inhibition; and high-throughput X-ray crystallography (via secondments to Diamond (Partner)). In doing so, the fellow will (a) enhance his prospects of becoming an independent academic group leader in Europe and (b) address the need to train researchers in key multidisciplinary areas such as medicinal chemistry and chemical biology and (c) develop cutting edge synthetic methods that facilitates the fragment-based discovery of new inhibitors for protein-protein interactions. By building in fragment hits from the Host laboratory, the fellow will establish a synthetic toolkit enabling the functionalization of C-H bonds within N-heterocycles with a wide range of medicinally-relevant groups. The fellowship will explore three main modes of reactivity to establish the functionalization of sp3-hydridised carbons with heterocyclic fragments and showcase the value of the synthetic toolbox through the discovery of fragments hits into potent inhibitors of PPIs involving the ATAD2 bromodomain.

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The information about "SYNFOS" are provided by the European Opendata Portal: CORDIS opendata.

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