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SYNFOS

Synthetic toolkit for fragment oriented synthesis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SYNFOS project word cloud

Explore the words cloud of the SYNFOS project. It provides you a very rough idea of what is the project "SYNFOS" about.

medicinal    strategy    leader    tends    bonds    despite    adam    medical    ray    toolbox    inhibitors    cutting    exploration    interaction    independent    edge    space    functionalization    steve    protein    chemistry    drugs    laboratory    facilitates    uneven    unmet    heterocycles    supervisor    tend    alexandre    direct    ppis    heterocyclic    reactivity    fbld    groups    hits    building    molecular    trindade    discover    marsden    mainstream    advantageous    firstly    elaborated    fragments    host    synthetic    potent    synfos    treatment    secondly    university    nelson    fellowship    novo    train    expertise    interactions    atad2    sp3    ligand    modes    carbons    showcase    synthesised    secondments    toolkit    lipophilic    multidisciplinary    throughput    co    diamond    inhibition    leeds    join    prospects    biology    medicinally    remarkable    flatter    discovery    hydridised    yielding    compounds    fellow    academic    elaboration    crystallography    chemical    explore    exacerbate    group    bromodomain    fragment    de    professors    catalysis   

Project "SYNFOS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.asn.leeds.ac.uk/view_person
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00

Map

 Project objective

Fragment-based ligand discovery (FBLD) has become a mainstream strategy to discover new drugs to enable the treatment of conditions with unmet medical needs. Despite the remarkable rise of FBLD, significant chemical challenges remain in the field; firstly, elaborated fragments tend to be synthesised de novo when direct growth would be much more advantageous. Secondly, the currently available toolkit for fragment elaboration tends to exacerbate an uneven exploration of chemical space, yielding flatter and more lipophilic compounds.

SYNFOS will allow Alexandre Trindade (the fellow) to join the laboratory of Professors Adam Nelson (host supervisor) and Steve Marsden (host co-supervisor) at the University of Leeds (Host) and develop research expertise in fragment-based ligand discovery; catalysis to enable molecular discovery; protein-protein interaction (PPIs) inhibition; and high-throughput X-ray crystallography (via secondments to Diamond (Partner)). In doing so, the fellow will (a) enhance his prospects of becoming an independent academic group leader in Europe and (b) address the need to train researchers in key multidisciplinary areas such as medicinal chemistry and chemical biology and (c) develop cutting edge synthetic methods that facilitates the fragment-based discovery of new inhibitors for protein-protein interactions. By building in fragment hits from the Host laboratory, the fellow will establish a synthetic toolkit enabling the functionalization of C-H bonds within N-heterocycles with a wide range of medicinally-relevant groups. The fellowship will explore three main modes of reactivity to establish the functionalization of sp3-hydridised carbons with heterocyclic fragments and showcase the value of the synthetic toolbox through the discovery of fragments hits into potent inhibitors of PPIs involving the ATAD2 bromodomain.

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The information about "SYNFOS" are provided by the European Opendata Portal: CORDIS opendata.

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