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TakeupSLaCk SIGNED

Role and regulation of dendritic cell functions by Solute Carrier Transporters

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TakeupSLaCk project word cloud

Explore the words cloud of the TakeupSLaCk project. It provides you a very rough idea of what is the project "TakeupSLaCk" about.

drugs    transcriptional    vivo    export    family    proteins    insights    dying    material    rare    phagocytes    adapt    healthy    pathogens    immune    acids    dc    lipids    plethora    deal    cutting    reveal    billions    carrier    dissect    apoptotic    dictate    edge    solute    metabolic    dcs    turn    prrs    heterogeneous    import    cells    elimination    cargos    relevance    ions    functions    helps    transporters    pathogen    tissue    sensing    prevent    infectious    homeostasis    technologies    phagocytic    equipped    immunogenic    altogether    relatively    dreaded    vast    genome    sophisticated    mouse    bound    slc    human    therapeutics    efficient    beginning    recruiting    fatty    programs    recognition    expression    slcs    membrane    initation    machinery    lymphocytes    nutrients    biology    altered    fast    group    linked    first    dendritic    reflected    wil    confronted    tolerogenic    function    receptors    comprise    time    autoimmunity    ingested    regulation    mediate    models    daily    presenting    external    antigens    diseases    drug    engulfment    appreciate    adaptive   

Project "TakeupSLaCk" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 160˙800.00

Map

 Project objective

Phagocytes are confronted daily with the dreaded task to respond to billions of dying cells and a plethora of external pathogens. Dendritic cells (DCs) comprise a heterogeneous group of phagocytes that are equipped with several phagocytic and pathogen recognition receptors (PRRs), and with the processing machinery to mediate efficient elimination of apoptotic or infectious cargos. This, in turn, helps to maintain tissue homeostasis and prevent autoimmunity. However, there is fast-growing evidence that DC functions also affect metabolic pathways. Moreover, we are now beginning to appreciate that phagocytes need to adapt to metabolic changes and deal with the ingested material by recruiting, among others, the membrane-bound solute carrier transporters (SLCs). SLCs are the second largest family of membrane proteins in the human genome, yet remain relatively under-studied. SLCs mediate the import and export of ions, nutrients, lipids, fatty acids or drugs, and the relevance of their functions is reflected by the vast number of diseases linked to altered expression or function of SLCs, and the many drugs that target SLCs. Using sophisticated mouse models, we will analyse the expression of SLCs in DC subsets in vivo upon engulfment of apoptotic or infectious cargos. Using cutting edge technologies, we will dissect the transcriptional and metabolic programs that dictate functions of DC subsets in both tolerogenic and immunogenic conditions. We wil address, for the first time, the role of SLCs in major DC functions such as sensing pathogens and presenting antigens to T lymphocytes for the initation of adaptive immune responses. Altogether, this study will provide new insights into SLC regulation and DC biology. This proposal has the potential not only to reveal novel aspects of the use of SLCs for drug development and therapeutics of both common and rare diseases, and to enhance the targeting of engulfment or of metabolic pathways in healthy states.

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The information about "TAKEUPSLACK" are provided by the European Opendata Portal: CORDIS opendata.

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