Opendata, web and dolomites

TakeupSLaCk SIGNED

Role and regulation of dendritic cell functions by Solute Carrier Transporters

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TakeupSLaCk project word cloud

Explore the words cloud of the TakeupSLaCk project. It provides you a very rough idea of what is the project "TakeupSLaCk" about.

beginning    fatty    cutting    fast    dreaded    linked    healthy    models    presenting    mediate    sensing    dendritic    vast    dc    human    solute    infectious    deal    phagocytes    homeostasis    tissue    nutrients    regulation    functions    adapt    bound    time    recruiting    machinery    appreciate    metabolic    prevent    drugs    immunogenic    material    antigens    equipped    carrier    mouse    membrane    proteins    heterogeneous    autoimmunity    insights    altered    tolerogenic    dictate    drug    daily    pathogen    pathogens    prrs    efficient    elimination    export    diseases    function    expression    cargos    phagocytic    transcriptional    wil    billions    comprise    slcs    genome    slc    receptors    therapeutics    programs    sophisticated    acids    first    ions    dcs    cells    altogether    dying    apoptotic    reflected    initation    external    ingested    turn    relevance    immune    import    helps    edge    recognition    rare    dissect    technologies    transporters    adaptive    confronted    lipids    engulfment    vivo    lymphocytes    relatively    group    reveal    family    biology    plethora   

Project "TakeupSLaCk" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 160˙800.00

Map

 Project objective

Phagocytes are confronted daily with the dreaded task to respond to billions of dying cells and a plethora of external pathogens. Dendritic cells (DCs) comprise a heterogeneous group of phagocytes that are equipped with several phagocytic and pathogen recognition receptors (PRRs), and with the processing machinery to mediate efficient elimination of apoptotic or infectious cargos. This, in turn, helps to maintain tissue homeostasis and prevent autoimmunity. However, there is fast-growing evidence that DC functions also affect metabolic pathways. Moreover, we are now beginning to appreciate that phagocytes need to adapt to metabolic changes and deal with the ingested material by recruiting, among others, the membrane-bound solute carrier transporters (SLCs). SLCs are the second largest family of membrane proteins in the human genome, yet remain relatively under-studied. SLCs mediate the import and export of ions, nutrients, lipids, fatty acids or drugs, and the relevance of their functions is reflected by the vast number of diseases linked to altered expression or function of SLCs, and the many drugs that target SLCs. Using sophisticated mouse models, we will analyse the expression of SLCs in DC subsets in vivo upon engulfment of apoptotic or infectious cargos. Using cutting edge technologies, we will dissect the transcriptional and metabolic programs that dictate functions of DC subsets in both tolerogenic and immunogenic conditions. We wil address, for the first time, the role of SLCs in major DC functions such as sensing pathogens and presenting antigens to T lymphocytes for the initation of adaptive immune responses. Altogether, this study will provide new insights into SLC regulation and DC biology. This proposal has the potential not only to reveal novel aspects of the use of SLCs for drug development and therapeutics of both common and rare diseases, and to enhance the targeting of engulfment or of metabolic pathways in healthy states.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TAKEUPSLACK" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TAKEUPSLACK" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CHES (2020)

Resilience of Coastal Human-Environment Systems

Read More  

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

ICL CHROM (2020)

DNA interstrand crosslink repair and chromatin remodelling

Read More