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TakeupSLaCk SIGNED

Role and regulation of dendritic cell functions by Solute Carrier Transporters

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TakeupSLaCk project word cloud

Explore the words cloud of the TakeupSLaCk project. It provides you a very rough idea of what is the project "TakeupSLaCk" about.

membrane    turn    cargos    phagocytes    adaptive    mouse    pathogens    genome    healthy    autoimmunity    helps    prevent    relevance    vivo    metabolic    cells    dictate    elimination    dc    sophisticated    first    fast    regulation    heterogeneous    mediate    confronted    ingested    immunogenic    deal    plethora    appreciate    reflected    insights    rare    beginning    import    acids    human    apoptotic    dissect    bound    receptors    transporters    dcs    altogether    efficient    comprise    altered    tissue    daily    tolerogenic    antigens    dendritic    carrier    biology    reveal    phagocytic    technologies    sensing    recruiting    time    equipped    functions    solute    cutting    lipids    transcriptional    recognition    dreaded    ions    dying    function    programs    machinery    diseases    engulfment    therapeutics    relatively    wil    adapt    edge    linked    expression    material    models    group    immune    homeostasis    initation    presenting    proteins    billions    infectious    nutrients    prrs    pathogen    vast    family    export    slc    drug    external    fatty    lymphocytes    slcs    drugs   

Project "TakeupSLaCk" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 160˙800.00

Map

 Project objective

Phagocytes are confronted daily with the dreaded task to respond to billions of dying cells and a plethora of external pathogens. Dendritic cells (DCs) comprise a heterogeneous group of phagocytes that are equipped with several phagocytic and pathogen recognition receptors (PRRs), and with the processing machinery to mediate efficient elimination of apoptotic or infectious cargos. This, in turn, helps to maintain tissue homeostasis and prevent autoimmunity. However, there is fast-growing evidence that DC functions also affect metabolic pathways. Moreover, we are now beginning to appreciate that phagocytes need to adapt to metabolic changes and deal with the ingested material by recruiting, among others, the membrane-bound solute carrier transporters (SLCs). SLCs are the second largest family of membrane proteins in the human genome, yet remain relatively under-studied. SLCs mediate the import and export of ions, nutrients, lipids, fatty acids or drugs, and the relevance of their functions is reflected by the vast number of diseases linked to altered expression or function of SLCs, and the many drugs that target SLCs. Using sophisticated mouse models, we will analyse the expression of SLCs in DC subsets in vivo upon engulfment of apoptotic or infectious cargos. Using cutting edge technologies, we will dissect the transcriptional and metabolic programs that dictate functions of DC subsets in both tolerogenic and immunogenic conditions. We wil address, for the first time, the role of SLCs in major DC functions such as sensing pathogens and presenting antigens to T lymphocytes for the initation of adaptive immune responses. Altogether, this study will provide new insights into SLC regulation and DC biology. This proposal has the potential not only to reveal novel aspects of the use of SLCs for drug development and therapeutics of both common and rare diseases, and to enhance the targeting of engulfment or of metabolic pathways in healthy states.

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