Explore the words cloud of the ACORN project. It provides you a very rough idea of what is the project "ACORN" about.
The following table provides information about the project.
Coordinator |
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Organization address contact info |
Coordinator Country | Portugal [PT] |
Total cost | 1˙000˙000 € |
EC max contribution | 1˙000˙000 € (100%) |
Programme |
1. H2020-EU.4.b. (Twinning of research institutions) |
Code Call | H2020-WIDESPREAD-05-2017-Twinning |
Funding Scheme | CSA |
Starting year | 2018 |
Duration (year-month-day) | from 2018-09-01 to 2021-08-31 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES | PT (LISBOA) | coordinator | 353˙750.00 |
2 | THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE | UK (CAMBRIDGE) | participant | 216˙250.00 |
3 | PERCUROS BV | NL (LEIDEN) | participant | 215˙000.00 |
4 | ACADEMISCH ZIEKENHUIS LEIDEN | NL (LEIDEN) | participant | 85˙000.00 |
5 | BIERAU SCHMEISER KATJA | IT (VELLETRI) | participant | 65˙000.00 |
6 | DE MARCHIS VERONICA | IT (COLLEFERRO) | participant | 65˙000.00 |
Carbon monoxide (CO) has gathered increasing attention because of its role as a gasotransmitter with therapeutic and cell-protective effects. It is also recognised as a cell-signalling molecule where recent developments in the area of CO-releasing molecules (CORMs) and materials for controlled CO application have shown their importance with respect to delivery of such agents to their respective targets. However, despite their promise, their remains two major bottlenecks that may prevent these compounds from reaching the clinic. Firstly, the precise spatial-temporal CO release of CORMs is not target-specific. The CO molecule is highly diffusive and binds to haemoproteins, which are ubiquitous. Secondly, CORMs are made of metal carbonyl complexes and as organometallic compounds, there is the potential of heavy metal toxicity. Moreover, since CORMs are water-soluble they are distributed throughout the body, which can lead to further increased toxicities against healthy tissues. Our project aims to alleviate some of the problems of CORMs by a) developing a method to monitor CO release by MRI and optical imaging; b) reformulate CORMs by encapsulating inside nanomaterials (specifically the FDA approved PLGA as a nanocarrier) and c) provide targeting of the CORMs to their site of delivery by conjugating peptide targeting moieties to the surface of the PLGA nanoparticle. Through the completion of these activities, I;;, supported by its twinning partners, is in the best position to achieve an improved capability to compete for internationally competitive research funding and to access business stakeholders. By claiming its position in research and innovation networks IMM will effectively contribute to research excellence and value creation in health at European level.
Launch of website | Websites, patent fillings, videos etc. | 2020-04-02 20:43:27 |
Development of the project logo/brand | Websites, patent fillings, videos etc. | 2020-04-02 20:43:18 |
Brochure and flyer development | Websites, patent fillings, videos etc. | 2020-04-02 20:43:40 |
Take a look to the deliverables list in detail: detailed list of ACORN deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2020 |
Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien GarcÃa-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies published pages: , ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.03.050 |
Journal of Controlled Release | 2020-04-15 |
2020 |
Tiago Rodrigues, Gonçalo J.L. Bernardes Machine learning for target discovery in drug development published pages: 16-22, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2019.10.003 |
Current Opinion in Chemical Biology 56 | 2020-02-05 |
2019 |
Charlotte Baker, Tiago Rodrigues, Bernardo P. de Almeida, Nuno L. Barbosa-Morais, Gonçalo J.L. Bernardes Natural product–drug conjugates for modulation of TRPV1-expressing tumors published pages: 2531-2536, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.03.025 |
Bioorganic & Medicinal Chemistry 27/12 | 2020-02-05 |
2019 |
Daniel Reker, Gonçalo J. L. Bernardes, Tiago Rodrigues Computational advances in combating colloidal aggregation in drug discovery published pages: 402-418, ISSN: 1755-4330, DOI: 10.1038/s41557-019-0234-9 |
Nature Chemistry 11/5 | 2020-02-05 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ACORN" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "ACORN" are provided by the European Opendata Portal: CORDIS opendata.