Opendata, web and dolomites

LeukemiaEnviron SIGNED

SIGNALING PROPENSITY IN THE MICROENVIRONMENT OF B CELL CHRONIC LYMPHOCYTIC LEUKEMIA

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 LeukemiaEnviron project word cloud

Explore the words cloud of the LeukemiaEnviron project. It provides you a very rough idea of what is the project "LeukemiaEnviron" about.

engraftment    times    blood    biology    proteins    microenvironments    chronic    acts    microenvironment    node    mirnas    integrate    re    hypothesize    proliferation    proliferative    relevance    stable    vs    signalling    interactions    transferable    niches    survival    dependency    pro    signaling    cell    inhibitors    influences    therapeutic    function    therapeutically    primary    figure    see    receptor    stream    mediated    malignancies    regulation    model    first    normal    immune    rituximab    signals    adults    regulator    animal    obtain    implication    cells    nodes    activation    circulate    cll    responsible    malignant    interleukin    samples    lymph    therapy    29    cd40    inhibited    therapies    print    utilized    12    cd20    lymphocytic    reveal    complicates    finger    led    transplantable    bcr    nfkb    pdx    il4    peripheral    mechanisms    interaction    mir    unknown    propensity    mouse    constantly    universal    microenvironmental    frequent    data    course    leukemia    disease   

Project "LeukemiaEnviron" data sheet

The following table provides information about the project.

Coordinator
Masarykova univerzita 

Organization address
address: Zerotinovo namesti 9
city: BRNO STRED
postcode: 60177
website: http://www.muni.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 1˙499˙990 €
 EC max contribution 1˙499˙990 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    Masarykova univerzita CZ (BRNO STRED) coordinator 1˙499˙990.00

Map

 Project objective

B cell chronic lymphocytic leukemia (CLL) is the most frequent leukemia in adults. CLL cells are characterized by their universal dependency on pro-survival and pro-proliferative signals from immune niches. To achieve this they constantly re-circulate between blood and lymph nodes, which is inhibited by novel microenvironment-targeting therapies such as “BCR inhibitors”. We aim to reveal how the malignant B cells change the propensity of their signalling pathways in response to the different microenvironments such as peripheral blood vs lymph node to obtain the proliferative signals. This is of major relevance for CLL, but also transferable to the biology of some other B cell malignancies and/or normal B cells. We analyzed the “finger print” of microenvironmental interactions in many CLL samples at various times during the disease course or during therapy. The obtained data led us to hypothesize on the mechanisms of regulation of signalling propensity of two pathways that are responsible for proliferation and survival of CLL cells, namely B Cell Receptor (BCR) signalling and signals from T-cells mediated by CD40/IL4. In aim 1 we hypothesize that CD20 is one of the key proteins involved in CLL cell activation, and influences BCR and interleukin signalling (see figure). This has important therapeutic implication since CD20 is used as a therapeutic target for 20 years (rituximab), but its function in CLL/normal B cells is unknown. In aim 2 we hypothesize that miR-29 acts a key regulator of T-cell signalling from CD40 and down-stream NFkB activation (see figure). This represents the first example of miRNAs‘ role in the propensity of T-cell interaction, and could be also utilized therapeutically. In aim 3 we will integrate our data on microenvironmental signaling (aim 12) and develop a first mouse model for PDX that would allow stable engraftment of primary CLL cells. Currently, CLL is non-transplantable to any animal model which complicates studies of its biology.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LEUKEMIAENVIRON" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LEUKEMIAENVIRON" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HYDROGEN (2019)

HighlY performing proton exchange membrane water electrolysers with reinforceD membRanes fOr efficient hydrogen GENeration

Read More  

REPLAY_DMN (2019)

A theory of global memory systems

Read More  

E-DIRECT (2020)

Evolution of Direct Reciprocity in Complex Environments

Read More