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EPICROP SIGNED

Dissecting epistasis for enhanced crop productivity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EPICROP project word cloud

Explore the words cloud of the EPICROP project. It provides you a very rough idea of what is the project "EPICROP" about.

biology    improvements    unknown    plants    map    molecular    sensitizing    crop    clear    acting    occurring    mutagenesis    principles    cryptic    improvement    epistasis    untapped    loci    screen    perturbations    trans    allelic    predictably    suggests    flower    profiling    exhaustive    cassettes    mads    breeding    resource    crops    fundamental    agriculture    outcomes    uncover    reveal    plant    first    predictable    genome    understand    efforts    gene    panel    regulatory    utilize    genotype    functional    quantitative    box    modifier    traits    preliminary    natural    naturally    crispr    genetic    leads    differences    navigate    transcript    epistatic    series    productivity    trait    linear    phenotype    regulate    variation    editing    mainly    model    area    weak    additive    quantitatively    networks    experimental    architecture    interactions    stem    data    cas9    economically    fruit    differentiation    guide    cell    diversity    tomato    signatures    genes    dissect    meet   

Project "EPICROP" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙903 €
 EC max contribution 1˙499˙903 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙499˙903.00

Map

 Project objective

A major goal in plant biology is to understand how naturally occurring genetic variation leads to quantitative differences in economically important traits. Efforts to navigate the genotype-to-phenotype map are often focused on linear genetic interactions. As a result, crop breeding is mainly driven by loci with predictable additive effects. However, it has become clear that quantitative trait variation often results from perturbations of complex genetic networks. Thus, understanding epistasis, or interactions between genes, is key for our ability to predictably improve crops. To meet this challenge, this project will reveal and dissect epistatic interactions in gene regulatory networks that guide stem cell differentiation in the model crop tomato. In the first aim, I will utilize exhaustive allelic series for epistatic MADS-box genes that quantitatively regulate flower and fruit production as an experimental model system to study fundamental principles of epistasis that can be applied to other genetic networks. Genome-wide transcript profiling will be used to reveal molecular signatures of epistasis and potential targets for predictable crop improvement by advanced CRISPR/Cas9 gene editing technology. Further, my preliminary data suggests that epistasis is widespread and important across major productivity traits in tomato. Thus, in a second aim, I will access this untapped resource of cryptic genetic variation by sensitizing a tomato diversity panel for weak epistatic effects from unknown natural modifier loci of stem cell differentiation using trans-acting CRISPR/Cas9 editing cassettes. This screen represents a new approach to mutagenesis in plants with potential to reveal cryptic variation in other system. The outcomes of this project will advance our knowledge in a fundamental area of plant genome biology, help uncover and understand the functional architecture of epistasis, and have potential to bring significant improvements to agriculture.

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The information about "EPICROP" are provided by the European Opendata Portal: CORDIS opendata.

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