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ArthritisHeal SIGNED

Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ArthritisHeal" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 3˙297˙271 €
 EC max contribution 3˙297˙271 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 796˙859.00
2    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 563˙965.00
3    CARDIFF UNIVERSITY UK (CARDIFF) participant 303˙172.00
4    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) participant 303˙172.00
5    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 303˙172.00
6    IMMUNOTECH SAS FR (MARSEILLE) participant 274˙802.00
7    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 256˙320.00
8    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 252˙788.00
9    PHARMAGNOSE VIOTECHNOLOGIKI ANONYMI ETAIREIA EL (CHALKIDA) participant 243˙017.00
10    AB Sciex Pte. Ltd CA (Concord) partner 0.00
11    ABBVIE INC US (NORTH CHICAGO IL) partner 0.00
12    DEHNE MATTHIAS NL (AMSTERDAM) partner 0.00
13    ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON EL (ATHINA) partner 0.00
14    PHARMATICS LIMITED UK (EDINBURGH) partner 0.00
15    STICHTING NATIONAAL REUMAFONDS NL (AMSTERDAM) partner 0.00
16    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00
17    THE SCRIPPS RESEARCH INSTITUTE US (LA JOLLA CA) partner 0.00

Map

 Project objective

In the ArthritisHeal project 7 universities and 2 companies, together with 8 associated partners, will train 12 young researchers and will discover novel therapeutic targets for two rheumatic diseases: osteoarthritis (OA) and rheumatoid arthritis (RA). The project will focus on the role of pro-resolving lipids, which play an important role in both diseases by stimulating resolution of inflammation. Both OA and RA cause pain and deformation of joints, with inflammation playing large role in the pathogenesis of both diseases. Current therapies, focused on inhibition of inflammation, are insufficient to cure rheumatic diseases. By exploiting pro-resolving mechanisms, novel therapeutic targets will be discovered in this project, ultimately improving RA and OA treatment. During the project both clinical samples and animal models will be used to study mode of action and verify clinically relevant lipids. Novel lipids discovered in pre-clinical models are validated in clinical samples, and the mode-of-action of known lipids will be determined in pre-clinical models. The consortium of academic and industrial beneficiaries with leading expertise in rheumatology, lipidomics, immunology and data analysis will provide scientific and technology training to ESRs. Associated partners will provide secondment opportunities and training, e.g. in regulatory and IP issues and career development. Each ESR will follow a personalised training programme combining clinical, biological and chemical insights to solve challenges in the development of treatments for rheumatic diseases. The ESRs will receive training both in an academic as well as an industrial setting. By studying the role of pro-resolving lipids in two important rheumatic diseases in conjunction, the consortium will: - Train young researchers in the interdisciplinary approach necessary to develop treatments for complex diseases. - Validate therapeutic targets in important pro-resolving lipid pathways.

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The information about "ARTHRITISHEAL" are provided by the European Opendata Portal: CORDIS opendata.

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