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TERMINATOR SIGNED

Ribosomal frameshifts as a novel mechanism to control RNA turnover in stress

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TERMINATOR project word cloud

Explore the words cloud of the TERMINATOR project. It provides you a very rough idea of what is the project "TERMINATOR" about.

codons    mrna    technological    mechanism    fire    changing    coupling    induce    serve    expand    talk    sense    containing    expression    suggesting    environment    mediated    accumulated    telomere    ultimately    manner    nonsense    concentrations    rna    homeostasis    demonstrated    premature    suggests    mechanisms    transcripts    functional    previously    composition    modulation    rf    adaptability    transcription    frameshifts    cross    decay    interconnection    cellular    environmental    ptc    preliminary    datasets    translation    yeast    5pseq    cell    signals    community    existence    ptcs    termination    lab    turnover    tested    stress    host    regulation    maintenance    human    performing    maintaining    nature    limiting    abundance    dependent    erroneous    degradation    regulated    ribosomal    cells    overcoming    eliminates    nmd    window    software    regulates    gene    pool    opens    occurring    surveillance    aging    explore    adapt    fast    paramount   

Project "TERMINATOR" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 191˙852.00

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 Project objective

Modulation of gene expression is key for maintaining cellular homeostasis in the changing environment. It is achieved through controlling the processes of transcription and RNA degradation that ultimately affect abundance and composition of the mRNA pool. Emerging evidence suggests that the pathways of RNA surveillance and degradation are of paramount importance for fast adaptation of gene expression to stress. One of the most studied mechanisms controlling RNA turnover is nonsense-mediated decay (NMD). It eliminates erroneous transcripts containing premature termination codons (PTC), and also regulates expression of functional transcripts in condition-dependent manner. Recently, my host lab has demonstrated existence of widespread coupling between mRNA decay and translation. This opens a new window for translation dependent regulation of RNA turnover. Specifically, recent studies show that ribosomal frameshifts (RF) occurring during translation induce PTCs and fire NMD response. Preliminary evidence from the host lab suggests that RF is regulated upon stress and could serve as a new mechanism to sense environmental signals and adapt mRNA concentrations. It is yet to be tested if such a regulation is of widespread nature in the cell. The main goal of this project is to investigate stress-dependent regulation of ribosomal frameshifts and their role in RNA turnover. The 5PSeq approach developed in the host lab will allow for performing high-scale analysis in yeast and human cells, and overcoming existing technological challenges previously limiting research in the field. This project will also explore the cross-talk between RNA turnover and telomere maintenance in cellular response to stress and aging. This will expand the accumulated evidence suggesting interconnection of RNA turnover with other processes involved in cellular adaptability. Finally, I will develop a software package for analysis of RNA degradation datasets that can be used by the research community.

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The information about "TERMINATOR" are provided by the European Opendata Portal: CORDIS opendata.

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