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TERMINATOR SIGNED

Ribosomal frameshifts as a novel mechanism to control RNA turnover in stress

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TERMINATOR project word cloud

Explore the words cloud of the TERMINATOR project. It provides you a very rough idea of what is the project "TERMINATOR" about.

mechanism    eliminates    ribosomal    surveillance    environment    fire    frameshifts    software    sense    serve    coupling    concentrations    suggests    opens    pool    containing    overcoming    performing    tested    dependent    transcripts    termination    interconnection    gene    translation    cell    erroneous    nature    rna    adapt    ptc    talk    existence    limiting    human    ptcs    suggesting    adaptability    expression    demonstrated    cellular    occurring    regulation    preliminary    aging    community    paramount    degradation    manner    mediated    cells    mrna    stress    transcription    lab    ultimately    changing    codons    yeast    turnover    functional    5pseq    host    accumulated    environmental    signals    composition    induce    cross    previously    maintenance    telomere    fast    regulated    regulates    maintaining    window    modulation    datasets    premature    nonsense    homeostasis    explore    expand    decay    mechanisms    nmd    rf    technological    abundance   

Project "TERMINATOR" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 191˙852.00

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 Project objective

Modulation of gene expression is key for maintaining cellular homeostasis in the changing environment. It is achieved through controlling the processes of transcription and RNA degradation that ultimately affect abundance and composition of the mRNA pool. Emerging evidence suggests that the pathways of RNA surveillance and degradation are of paramount importance for fast adaptation of gene expression to stress. One of the most studied mechanisms controlling RNA turnover is nonsense-mediated decay (NMD). It eliminates erroneous transcripts containing premature termination codons (PTC), and also regulates expression of functional transcripts in condition-dependent manner. Recently, my host lab has demonstrated existence of widespread coupling between mRNA decay and translation. This opens a new window for translation dependent regulation of RNA turnover. Specifically, recent studies show that ribosomal frameshifts (RF) occurring during translation induce PTCs and fire NMD response. Preliminary evidence from the host lab suggests that RF is regulated upon stress and could serve as a new mechanism to sense environmental signals and adapt mRNA concentrations. It is yet to be tested if such a regulation is of widespread nature in the cell. The main goal of this project is to investigate stress-dependent regulation of ribosomal frameshifts and their role in RNA turnover. The 5PSeq approach developed in the host lab will allow for performing high-scale analysis in yeast and human cells, and overcoming existing technological challenges previously limiting research in the field. This project will also explore the cross-talk between RNA turnover and telomere maintenance in cellular response to stress and aging. This will expand the accumulated evidence suggesting interconnection of RNA turnover with other processes involved in cellular adaptability. Finally, I will develop a software package for analysis of RNA degradation datasets that can be used by the research community.

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The information about "TERMINATOR" are provided by the European Opendata Portal: CORDIS opendata.

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