Opendata, web and dolomites

TERMINATOR SIGNED

Ribosomal frameshifts as a novel mechanism to control RNA turnover in stress

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TERMINATOR project word cloud

Explore the words cloud of the TERMINATOR project. It provides you a very rough idea of what is the project "TERMINATOR" about.

occurring    human    changing    regulates    ptcs    adaptability    functional    explore    rna    demonstrated    gene    cross    surveillance    cells    maintaining    premature    fast    existence    nonsense    overcoming    suggests    ptc    paramount    composition    stress    expand    transcripts    regulated    preliminary    limiting    mechanisms    community    cellular    maintenance    nmd    lab    expression    nature    induce    ultimately    coupling    erroneous    frameshifts    eliminates    technological    accumulated    abundance    concentrations    5pseq    adapt    containing    aging    opens    rf    talk    manner    host    suggesting    window    datasets    pool    software    fire    mediated    regulation    cell    performing    translation    telomere    yeast    transcription    ribosomal    serve    degradation    interconnection    previously    mechanism    environmental    termination    mrna    decay    signals    environment    codons    tested    turnover    sense    dependent    modulation    homeostasis   

Project "TERMINATOR" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 191˙852.00

Map

 Project objective

Modulation of gene expression is key for maintaining cellular homeostasis in the changing environment. It is achieved through controlling the processes of transcription and RNA degradation that ultimately affect abundance and composition of the mRNA pool. Emerging evidence suggests that the pathways of RNA surveillance and degradation are of paramount importance for fast adaptation of gene expression to stress. One of the most studied mechanisms controlling RNA turnover is nonsense-mediated decay (NMD). It eliminates erroneous transcripts containing premature termination codons (PTC), and also regulates expression of functional transcripts in condition-dependent manner. Recently, my host lab has demonstrated existence of widespread coupling between mRNA decay and translation. This opens a new window for translation dependent regulation of RNA turnover. Specifically, recent studies show that ribosomal frameshifts (RF) occurring during translation induce PTCs and fire NMD response. Preliminary evidence from the host lab suggests that RF is regulated upon stress and could serve as a new mechanism to sense environmental signals and adapt mRNA concentrations. It is yet to be tested if such a regulation is of widespread nature in the cell. The main goal of this project is to investigate stress-dependent regulation of ribosomal frameshifts and their role in RNA turnover. The 5PSeq approach developed in the host lab will allow for performing high-scale analysis in yeast and human cells, and overcoming existing technological challenges previously limiting research in the field. This project will also explore the cross-talk between RNA turnover and telomere maintenance in cellular response to stress and aging. This will expand the accumulated evidence suggesting interconnection of RNA turnover with other processes involved in cellular adaptability. Finally, I will develop a software package for analysis of RNA degradation datasets that can be used by the research community.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TERMINATOR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TERMINATOR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ICL CHROM (2020)

DNA interstrand crosslink repair and chromatin remodelling

Read More  

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

GENI (2019)

Gender, emotions and national identities: a new perspective on the abortion debates in Italy (1971-1981).

Read More