Opendata, web and dolomites

SILIA SIGNED

Solid Immersion Lens Microscopy to Study Cilia Assembly

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SILIA project word cloud

Explore the words cloud of the SILIA project. It provides you a very rough idea of what is the project "SILIA" about.

cilium    organisms    project    host    omnipresence    budding    sil    achievements    body    functions    biology    ciliary    reconstitution    place    domain    parasites    eukaryotic    od    evolutionary    organization    cilia    cell    cryo    enigmatic    stabilization    structures    sensing    dynamic    broaden    ultrastructure    optics    vital    unraveling    signaling    data    trains    orchestrated    sole    intraflagellar    lab    correlative    trypanosomatids    unknown    vesicles    self    light    transport    turning    proteome    microscopy    spectrum    employing    biological    environment    organelles    constituting    mechanical    cryogenic    electron    technique    broad    point    solid    lens    immersion    explains    model    conserved    vitro    integrate    disorders    survival    synthetic    ciliopathies    ing    domains    imaging    indispensable    tip    mechanistic    hampers    principles    motility    human    cytoskeleton    capping    congenital    flagella    largely    therapeutic    provides    symptoms    gain   

Project "SILIA" data sheet

The following table provides information about the project.

Coordinator
USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE 

Organization address
address: VIDENSKA 1083
city: PRAHA 4
postcode: 142 20
website: www.img.cas.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 156˙980 €
 EC max contribution 156˙980 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-04   to  2021-09-27

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE CZ (PRAHA 4) coordinator 156˙980.00

Map

 Project objective

Cilia and flagella are evolutionary conserved organelles indispensable for vital processes in eukaryotic organisms, such as environment sensing, cell motility, signaling and development. Broad spectrum of ciliary functions, together with omnipresence of the cilium throughout human body, explains the range of symptoms associated with congenital ciliary disorders called ciliopathies. On the other hand, cilia are essential for survival of parasites, such as trypanosomatids, in the host. Therefore, cilia are of great interest as a potential therapeutic target. The ciliary tip is an essential ciliary domain; it provides capping and mechanical stabilization of the ciliary cytoskeleton, it is a turning point of the intraflagellar transport trains, a sole place of cilium growth and a place of budding of signaling vesicles. Yet the tip is the most enigmatic of all ciliary domains, with structures constituting the ciliary tip largely unknown. This hampers our understanding of how are the tip-related processes brought about and orchestrated. To gain insight into the dynamic ultrastructure od the ciliary tip, I will develop a novel technique for cryogenic correlative light and electron microscopy based on solid immersion lens (SIL) optics. I will integrate the resulting imaging data with the tip proteome project project carried out by the host lab and provide mechanistic understanding of the resulting tip model by employing top-down synthetic biology and in vitro reconstitution approaches. Key achievements of this project will include: (i) development of the cryo-SIL technique and (ii) unraveling the functions of the the ciliary tip domain, which will broaden our knowledge of the principles of self-organization of biological systems.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SILIA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SILIA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

CHES (2020)

Resilience of Coastal Human-Environment Systems

Read More  

BirthControlEnvirons (2019)

Contraception meets the environment: everyday contraceptive practices, politics, and futures in a toxic age

Read More