Opendata, web and dolomites

SILIA SIGNED

Solid Immersion Lens Microscopy to Study Cilia Assembly

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SILIA project word cloud

Explore the words cloud of the SILIA project. It provides you a very rough idea of what is the project "SILIA" about.

reconstitution    ing    flagella    trypanosomatids    place    correlative    largely    ciliopathies    spectrum    enigmatic    gain    organization    unraveling    self    body    parasites    point    host    vitro    sole    structures    domains    achievements    signaling    therapeutic    imaging    capping    stabilization    explains    biological    disorders    immersion    broaden    dynamic    tip    conserved    optics    light    budding    employing    congenital    hampers    unknown    sensing    turning    provides    integrate    organelles    mechanistic    eukaryotic    lens    solid    data    lab    indispensable    environment    sil    broad    evolutionary    model    mechanical    vital    motility    synthetic    cilia    proteome    orchestrated    od    human    project    biology    ciliary    domain    vesicles    ultrastructure    cytoskeleton    functions    cryogenic    cilium    cryo    survival    principles    cell    constituting    trains    electron    microscopy    omnipresence    intraflagellar    symptoms    transport    technique    organisms   

Project "SILIA" data sheet

The following table provides information about the project.

Coordinator
USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE 

Organization address
address: VIDENSKA 1083
city: PRAHA 4
postcode: 142 20
website: www.img.cas.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 156˙980 €
 EC max contribution 156˙980 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-04   to  2021-09-27

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE CZ (PRAHA 4) coordinator 156˙980.00

Map

 Project objective

Cilia and flagella are evolutionary conserved organelles indispensable for vital processes in eukaryotic organisms, such as environment sensing, cell motility, signaling and development. Broad spectrum of ciliary functions, together with omnipresence of the cilium throughout human body, explains the range of symptoms associated with congenital ciliary disorders called ciliopathies. On the other hand, cilia are essential for survival of parasites, such as trypanosomatids, in the host. Therefore, cilia are of great interest as a potential therapeutic target. The ciliary tip is an essential ciliary domain; it provides capping and mechanical stabilization of the ciliary cytoskeleton, it is a turning point of the intraflagellar transport trains, a sole place of cilium growth and a place of budding of signaling vesicles. Yet the tip is the most enigmatic of all ciliary domains, with structures constituting the ciliary tip largely unknown. This hampers our understanding of how are the tip-related processes brought about and orchestrated. To gain insight into the dynamic ultrastructure od the ciliary tip, I will develop a novel technique for cryogenic correlative light and electron microscopy based on solid immersion lens (SIL) optics. I will integrate the resulting imaging data with the tip proteome project project carried out by the host lab and provide mechanistic understanding of the resulting tip model by employing top-down synthetic biology and in vitro reconstitution approaches. Key achievements of this project will include: (i) development of the cryo-SIL technique and (ii) unraveling the functions of the the ciliary tip domain, which will broaden our knowledge of the principles of self-organization of biological systems.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SILIA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SILIA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

SolarIC (2019)

A New Monitor for Cosmic Rays in the Solar System: Inverse-Compton Emission from Cosmic-Ray Electrons Scattering with Sunlight

Read More  

SynECS (2019)

Combining carbon nanotubes and gold nanorods to investigate the extracellular space around synapses during neuronal communication

Read More  

Comedy and Politics (2018)

The Comedy of Political Philosophy. Democratic Citizenship, Political Judgment, and Ideals in Political Practice.

Read More