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SILIA SIGNED

Solid Immersion Lens Microscopy to Study Cilia Assembly

Total Cost €

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EC-Contrib. €

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Partnership

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 SILIA project word cloud

Explore the words cloud of the SILIA project. It provides you a very rough idea of what is the project "SILIA" about.

parasites    survival    vitro    turning    place    indispensable    eukaryotic    microscopy    immersion    lab    tip    integrate    principles    therapeutic    unknown    constituting    vesicles    synthetic    cytoskeleton    electron    enigmatic    solid    disorders    broad    transport    conserved    imaging    provides    functions    omnipresence    technique    biology    proteome    vital    reconstitution    motility    domains    signaling    ultrastructure    budding    evolutionary    gain    mechanical    flagella    ing    point    light    body    stabilization    ciliopathies    domain    model    congenital    cilium    biological    project    sole    cilia    achievements    broaden    ciliary    trains    self    optics    trypanosomatids    host    employing    human    dynamic    sensing    cryogenic    organelles    data    cell    lens    orchestrated    explains    structures    unraveling    symptoms    sil    largely    mechanistic    intraflagellar    spectrum    cryo    organisms    organization    od    environment    hampers    correlative    capping   

Project "SILIA" data sheet

The following table provides information about the project.

Coordinator
USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE 

Organization address
address: VIDENSKA 1083
city: PRAHA 4
postcode: 142 20
website: www.img.cas.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 156˙980 €
 EC max contribution 156˙980 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-04   to  2021-09-27

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE CZ (PRAHA 4) coordinator 156˙980.00

Map

 Project objective

Cilia and flagella are evolutionary conserved organelles indispensable for vital processes in eukaryotic organisms, such as environment sensing, cell motility, signaling and development. Broad spectrum of ciliary functions, together with omnipresence of the cilium throughout human body, explains the range of symptoms associated with congenital ciliary disorders called ciliopathies. On the other hand, cilia are essential for survival of parasites, such as trypanosomatids, in the host. Therefore, cilia are of great interest as a potential therapeutic target. The ciliary tip is an essential ciliary domain; it provides capping and mechanical stabilization of the ciliary cytoskeleton, it is a turning point of the intraflagellar transport trains, a sole place of cilium growth and a place of budding of signaling vesicles. Yet the tip is the most enigmatic of all ciliary domains, with structures constituting the ciliary tip largely unknown. This hampers our understanding of how are the tip-related processes brought about and orchestrated. To gain insight into the dynamic ultrastructure od the ciliary tip, I will develop a novel technique for cryogenic correlative light and electron microscopy based on solid immersion lens (SIL) optics. I will integrate the resulting imaging data with the tip proteome project project carried out by the host lab and provide mechanistic understanding of the resulting tip model by employing top-down synthetic biology and in vitro reconstitution approaches. Key achievements of this project will include: (i) development of the cryo-SIL technique and (ii) unraveling the functions of the the ciliary tip domain, which will broaden our knowledge of the principles of self-organization of biological systems.

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The information about "SILIA" are provided by the European Opendata Portal: CORDIS opendata.

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