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BABHY-CART SIGNED

Self-Healing Hydrogels for Material-Assisted Cell therapy in Osteoarthritis

Total Cost €

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EC-Contrib. €

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Partnership

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 BABHY-CART project word cloud

Explore the words cloud of the BABHY-CART project. It provides you a very rough idea of what is the project "BABHY-CART" about.

strategy    osteoarthritis    asc    confirmed    therapy    damaged    encapsulation    synthesize    europeans    hyaluronic    synthetic    medical    context    secretion    joints    adipose    immune    loaded    regenerative    innovative    treat    trophic    efficient    incurable    exists    degeneration    environment    obesity    seriously    class    stability    oa    injections    inflammation    self    msc    anti    soluble    limited    strategies    age    mesenchymal    pressing    stopping    million    population    survival    hydrogel    location    load    transplantation    mice    relaxation    characterizing    preclinical    original    cytoprotection    boronic    fast    hydrogels    injectability    acid    disease    promise    date    lasting    hold    fate    translational    models    viscoelastic    matrix    vivo    envisioned    prevalence    aging    mscs    progress    complementary    healing    therapies    plays    conventional    microenvironment    socioeconomically    debilitating    mitigate    biomaterials    reversing    painful    assisted    mechanical    hampered    appropriate    saline    efficacy    synovial    physicochemical    carefully    cell    intraarticular    mimic    injectable    immunomodulation    stromal    clinically    morphology   

Project "BABHY-CART" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE NANTES 

Organization address
address: QUAI DE TOURVILLE 1
city: NANTES CEDEX 1
postcode: 44035
website: www.univ-nantes.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE NANTES FR (NANTES CEDEX 1) coordinator 196˙707.00

Map

 Project objective

Osteoarthritis (OA) is an incurable and painful disease. Over 70 million Europeans are currently affected by OA – a number that is set to increase with aging population and prevalence of obesity. To date, no clinically-efficient therapy exists to treat this socioeconomically debilitating disease. In this context, innovative regenerative therapies for joints are a pressing medical challenge.

Intraarticular mesenchymal stromal cell (MSC) injections hold the great promise of stopping and reversing age-associated inflammation and degeneration of joints by providing the necessary trophic factors to mitigate immune responses. However, translational progress using conventional cell delivery (saline) has been seriously hampered by the limited control over cell survival, location and fate in damaged joints. It is now common knowledge that cell microenvironment plays a crucial role in the success of cell transplantation; and appropriate synthetic matrix design is key to success.

To address challenges in intraarticular MSC-based immunomodulation strategies, we have envisioned an original hydrogel-assisted cell therapy. In this strategy, an injectable hyaluronic acid (HA)-based hydrogel with long-lasting viscoelastic properties will allow MSC encapsulation and cytoprotection, ensuring the production of anti-OA soluble factors in vivo. To best mimic synovial environment and support MSCs in vivo, we will synthesize a novel boronic acid-based, self-healing HA hydrogel with unique properties of injectability, stability and fast relaxation under mechanical load.

After carefully characterizing the physicochemical properties of this new class of biomaterials, we will investigate the effects of cell encapsulation on adipose stromal cell (ASC) survival, morphology and factor secretion. Then, the preclinical efficacy of intraarticular injections of cell-loaded, self-healing hydrogels will be confirmed in two complementary OA mice models.

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The information about "BABHY-CART" are provided by the European Opendata Portal: CORDIS opendata.

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