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ARCS SIGNED

Elucidating the gene exchange networks of antibiotic resistance genes in clinical sewage microbiomes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ARCS project word cloud

Explore the words cloud of the ARCS project. It provides you a very rough idea of what is the project "ARCS" about.

leader    expertise    van    environment    genetic    commensals    hgt    successful    human    arcs    microbiology    parties    clinical    completion    ecosystem    amr    laboratory    ecosystems    skills    resistance    gut    transfer    bacteria    link    sources    select    deaths    therapy    mentoring    schaik    techniques    gene    sequencing    ensures    shown    dr    isolating    willem    throughput    pathogens    bacterial    reveal    pathogenic    sewage    realise    networks    prof    microbes    versa    wastewater    antibiotics    vice    antimicrobial    clinically    args    generating    accomplishment    assays    horizontal    zepeda    career    genomes    microbiomes    mobile    genes    analysing    lisandra    exchange    characterizing    host    birmingham    association    antibiotic    leadership    data    dna    promiscuous    isolates    training    diverse    group    international    university    microbial    conjugation    levels    spread    capture    culture    patients    treating    fellow    independent    hosts    supportive    infections   

Project "ARCS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 212˙933.00

Map

 Project objective

'Antibiotics are essential for treating bacterial infections. However, antimicrobial resistance (AMR) has spread among pathogenic bacteria, leading to therapy failure or deaths of patients. Due to their association with promiscuous mobile genetic elements, clinically important antibiotic resistance genes (ARGs) can spread rapidly among diverse bacteria through horizontal gene transfer (HGT). Due to HGT, identifying the microbial hosts of the ARGs in an ecosystem is a challenge. Importantly, it has been shown that ARGS can spread from human gut commensals to clinical pathogens and vice versa.

Wastewater from clinical sources can importantly select for HGT of ARGs between different microbes, as both antibiotics and ARGs are present at high levels. The aim of this project - 'ARCS' (Antibiotic Resistance in Clinical Sewage microbiomes), is to reveal the ARGs exchange networks in clinical sewage microbiomes. The research objectives are: 1) Link ARGs to microbial hosts by using novel culture-independent methods based on DNA high-throughput sequencing. 2) Link ARGs to mobile genetic elements by isolating, sequencing, and characterizing the genomes of the identified hosts of ARGs. 3) Evaluate whether the isolates can transfer their ARGs to clinical pathogens using conjugation assays. ARGS will thus lead to a step-change in our understanding of HGT of ARGs in complex microbial ecosystems.

The Fellow Dr. Lisandra Zepeda's expertise in generating and analysing DNA sequencing data and the host Prof. Willem van Schaik's international leadership in AMR ensure a successful completion of ARCS and a favourable knowledge transfer for both parties. Furthermore, the supportive environment of the University of Birmingham ensures the accomplishment of the Fellow's training in crucial areas such as microbial DNA capture sequencing, microbiology laboratory techniques, and mentoring skills. Thus, ARCS will enable Dr. Zepeda to realise her career goal of becoming a research group leader.'

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The information about "ARCS" are provided by the European Opendata Portal: CORDIS opendata.

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