Opendata, web and dolomites

BispecificsThatClick SIGNED

Combinatorial Antibody Synthesis for the Discovery of New Anti-Tumour Immunomodulators

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 BispecificsThatClick project word cloud

Explore the words cloud of the BispecificsThatClick project. It provides you a very rough idea of what is the project "BispecificsThatClick" about.

assembled    treatment    significantly    content    responsible    anti    constructs    kill    imaging    serve    mode    efficacy    cell    selectively    modern    identification    anticancer    linear    malignant    carcinogenic    antigen    harnessing    efficiency    combination    substrates    mabs    site    strategies    throughput    library    immunology    fight    community    speed    bind    reactions    immune    tagged    simultaneously    tissues    bioorthogonal    antigens    inefficiency    lie    lack    antibodies    tumour    tools    bispecific    ligation    lot    condensation    alder    immunondulatory    synthesis    therapeutic    extense    inverse    treatments    tag    acceleration    cancer    medicine    platform    led    scaffold    healthy    specificities    tedious    herein    scientific    binding    action    linkers    demand    classic    monoclonal    cells    of    select    trigger    combinations    tested    modality    bsabs    diels    slow    electron    consist    methodology   

Project "BispecificsThatClick" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-03   to  2021-06-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 212˙933.00

Map

 Project objective

Cancer represents one of the major challenges for modern medicine as we still lack tools to selectively target malignant over healthy tissues. The main issues with state of the art anti-cancer treatments lie on their inefficiency and their associated side-effects. Improving this treatments has focused a lot of attention of the scientific community and has led to the development of new strategies. Harnessing our own immune system to fight malignant cells is one of the strategies with promising potential to improve cancer treatments, although challenges still remain. An emerging therapeutic modality to trigger our immune system against carcinogenic tissues are bispecific antibodies (bsAbs). bsAbs are the combination of two antigen binding specificities on a common scaffold. The potential of these constructs to bind to two antigens can be used to simultaneously target cancer cells and the immune cell which will effectively kill it. The problem of bsAbs is their slow and tedious production process, which is responsible for their linear development. Herein we propose a methodology to speed up and improve the efficiency of their production. Our approach will consist in using novel site-specific bioorthogonal ligation reactions to tag monoclonal antibodies (mAbs) with linkers that will serve as substrates for an inverse electron demand Diels Alder condensation. By condensation of different combinations of tagged mAbs a library of bsAbs will be assembled. The immunondulatory properties of the bsAbs will be tested in high throughput using a high content imaging platform. We will be able to select potential bsAbs for anticancer treatment from our extense library which will study in more depth using classic immunology methods to determine their mode of action and their anti tumour efficacy. The acceleration of both the synthesis and identification of relevant bsAbs for anticancer treatments would significantly increase the presence and value of this technology.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BISPECIFICSTHATCLICK" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BISPECIFICSTHATCLICK" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

GENI (2019)

Gender, emotions and national identities: a new perspective on the abortion debates in Italy (1971-1981).

Read More  

ICL CHROM (2020)

DNA interstrand crosslink repair and chromatin remodelling

Read More