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pyrroQuin SIGNED

Synthesis and Biological Evaluation of Pyrroquinoline Pseudo-Natural Products

Total Cost €

EC-Contrib. €

Partnership

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pyrroQuin project word cloud

Explore the words cloud of the pyrroQuin project. It provides you a very rough idea of what is the project "pyrroQuin" about.

fragments cellular active gt combination pseudo pyrroquinoline nps foundation chemical biology structural lay submit compounds synthesis potentially identification collections tetrahydroquinoline purpose relationships isolation biological pyrrolidine assays sar tools probes form discovery candidates structure small drug diastereo scaffolds affinity natural uncharted source drugs phenotypical compound molecule serve molecules enantioselective screening explore

Project "pyrroQuin" data sheet

The following table provides information about the project.

Coordinator	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	162˙806 €
EC max contribution	162˙806 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-EF-ST
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	coordinator	162˙806.00

Map

Project objective

Natural products (NPs) and their structural scaffolds are a rich source of small molecule tools for chemical biology and drug candidates. In a novel approach, this proposal will investigate the combination of natural product fragments to form pseudo-natural products (pseudo-NPs) with uncharted biological activity. The purpose of this project is to explore the diastereo- and enantioselective synthesis of two pyrroquinoline scaffolds, a combination of pyrrolidine and tetrahydroquinoline fragments, and submit the obtained compound collections (>100 compounds) to phenotypical screening assays to assess their biological activity. The obtained molecules could potentially serve as novel biological probes and lay the foundation for the discovery of novel targets or drugs. Highly active compounds will be used to establish structure activity relationships (SAR) and design affinity isolation probes for the identification of cellular targets.

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The information about "PYRROQUIN" are provided by the European Opendata Portal: CORDIS opendata.