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PhotoStem SIGNED

Photoswitching molecules for the spatiotemporal control of cancer stem cells with light

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PhotoStem project word cloud

Explore the words cloud of the PhotoStem project. It provides you a very rough idea of what is the project "PhotoStem" about.

mass    discovery    leaders    photoswitchable    inhibitors    photostem    effect    malignancies    expertise    techniques    cells    multidisciplinary    unaffected    induce    edge    truly    selective    photopharmacology    tools    host    xenograft    light    urge    stem    modulators    acts    space    overcome    despite    researcher    treatment    renew    recognised    biology    expand    population    myeloid    zebrafish    time    biological    haematological    learnings    solid    combine    activation    drug    experts    training    versions    disruptive    patient    bioactive    precise    small    thought    spatiotemporal    models    network    photoactivable    resistance    function    chemotherapy    tumour    cancer    repression    therapeutic    characterised    tumourigenesis    self    tumours    powerful    constitutes    leukemia    csc    bulk    vitro    cell    therapy    leaving    similarities    vivo    relapse    existence    initially    cscs    precisely    herein    normal    expansion    achievement    enormous    direction    cutting    molecules    innovation    directions   

Project "PhotoStem" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 160˙932.00

Map

 Project objective

PhotoStem aims to develop a cutting-edge approach to overcome the main cause of patient relapse in cancer treatment. Cancer stem cells (CSCs) are a small population of cells within a tumour characterised by their ability to self-renew and to induce tumourigenesis. Current chemotherapy acts only on the bulk of the tumour mass, leaving CSCs unaffected; this is thought to be the main cause of resistance to cancer treatment. Despite growing knowledge on the existence of CSCs, similarities to normal stem cells challenges the design of selective inhibitors and modulators. Relapse to cancer treatment is an enormous challenge and there is an urge to identify novel therapeutic approaches to target CSCs. Photopharmacology is an emerging field that seeks to precisely control the activity of bioactive molecules with light, allowing for activation or repression of biological function at a specific space and time. It constitutes a truly disruptive innovation that can represent a new direction in drug therapy. We herein propose to use novel photoactivable molecules to target CSCs with precise spatiotemporal control using light. Initially, we will develop novel photoswitchable versions of known inhibitors, and will study their effect in leukemia stem cells both in vitro and in zebrafish models. We will then expand our learnings to target CSCs of solid tumours. The achievement of such an ambitious objective will only be possible via a network of multidisciplinary researchers. The researcher will combine her expertise in drug discovery and leukemia with state-of-the-art photopharmacology techniques from leaders in the field at the host institution. Training-through-research at the partner organisations that include well-recognised experts in haematological malignancies, myeloid zebrafish models and CSC xenograft models will enable the expansion to in vivo applications. The proposed work will provide both new directions in targeted cancer therapy and powerful tools for cell biology.

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The information about "PHOTOSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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