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TBNANO SIGNED

Targeted intracellular delivery of antitubercular agents by functionalized nanocapsules

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TBNANO project word cloud

Explore the words cloud of the TBNANO project. It provides you a very rough idea of what is the project "TBNANO" about.

survive    pathogen    elimination    approved    biodegradable    surface    expertise    tuberculosis    training    macrophage    body    polysaccharide    transfer    young    anti    world    occurring    intracellular    distributed    antimicrobial    orally    closer    agent    science    biocompatible    resistant    treatment    selectivity    intravenously    decorated    mycobacterium    multidisciplinary    tb    functionalized    multidrug    enhanced    bacteria    alarming    ligands    efficient    cells    health    action    bioavailability    loaded    administered    purpose    nanocapsules    breakthrough    tbnano    extensively    infectious    free    drug    site    cellular    caused    macrophages    majority    derivatives    broaden    mannose    cell    valuable    vitro    antitubercular    reducing    disease    public    airborne    undesirable    causing    infected    worldwide    peptides    bedaquiline    nanomaterial    leads    limited    researcher    population    mainly    nanotechnology    drugs    host    naturally    quarter    molecules    directed   

Project "TBNANO" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 172˙932.00

Map

 Project objective

Tuberculosis (TB) is still a major public health problem worldwide. It is estimated that more than one-quarter of the world's population is infected with this airborne infectious disease. Moreover, the increase of multidrug- and extensively drug-resistant TB is alarming. TB is caused by Mycobacterium tuberculosis, an intracellular pathogen that can survive in host cells, mainly in macrophages. The uptake of the antitubercular drugs by infected host cells is limited. The orally or intravenously administered drugs are distributed throughout the body causing side effects and the majority of the drug molecules do not reach their targets. The elimination of the intracellular bacteria could be more efficient with host cell directed delivery. The TBNANO project aims to develop and in vitro evaluate antitubercular agent-loaded nanocapsules decorated with host cell targeting molecules. For this purpose, naturally occurring, biocompatible and biodegradable polysaccharide nanocapsules loaded with a recently approved anti-TB drug (bedaquiline) and antimicrobial peptides will be used. The surface of the nanocapsules will be functionalized with macrophage targeting ligands, such as peptides and mannose derivatives. With such nanotechnology-based drug delivery system, enhanced cellular uptake can be achieved by the host cell macrophages, therefore, the anti-TB agent can reach the intracellular bacteria as site of action. This approach leads to increased bioavailability and selectivity of the drugs while reducing their undesirable side effects. The proposed project could provide a breakthrough step in nanotechnology-based TB treatment to get closer to a world free of TB. Furthermore, this multidisciplinary project provide valuable transfer of knowledge to the host institution, as well as advanced training of the young researcher in the field of nanomaterial science to broaden her expertise in drug delivery systems.

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The information about "TBNANO" are provided by the European Opendata Portal: CORDIS opendata.

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