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BodyDMI SIGNED

Development of deuterium metabolic imaging to map body biochemistry with MRI

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BodyDMI project word cloud

Explore the words cloud of the BodyDMI project. It provides you a very rough idea of what is the project "BodyDMI" about.

2016    oral    therapies    innovation    2017    frequency    relies    combined    metabolic    complement    obesity    setup    image    humans    mode    scanner    outperformed    epidemic    lipid    commercial    diabetes    morphological    opens    efficacy    treatment    dynamic    01    array    techniques    ultra    imaging    compounds    window    arguably    resonance    earlier    coils    map    designs    hydrogen    uncompromised    mcube    labeled    sensitivity    hepatic    operates    cancer    deuterium    outperforms    dynamically    fet    ed    global    organ    patients    lack    proof    metabolism    dmi    300    mri    successful    diseases    spectroscopic    detect    dual    completion    mhz    invasive    disturbances    attributed    stage    drug    valorized    feasibility    body    coil    scan    loop    designed    3d    45    lagged    toxicity    idea    tesla    dipole    besides    clinical    transparent    administration    optimal    linked    session    operation    magnetic    biochemistry    carbohydrate    chemical    dramatic   

Project "BodyDMI" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 100˙000 €
 EC max contribution 100˙000 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-03
 Funding Scheme CSA
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 81˙250.00
2    WAVETRONICA BV NL (UTRECHT) participant 18˙750.00
3    MR COILS BV NL (ZALTBOMMEL) participant 0.00

Map

 Project objective

The global obesity epidemic has resulted in a dramatic rise in metabolic diseases and the development of effective therapies has greatly lagged behind. This could arguably be attributed to a lack of non-invasive (imaging) techniques to characterize disturbances in metabolic pathways. We will investigate the use of dynamic deuterium metabolic imaging (DMI) to dynamically map body biochemistry in humans in 3D imaging mode. DMI relies on deuterium magnetic resonance spectroscopic imaging combined with oral administration of deuterium-labeled compounds.

The innovation idea is linked to the MCUBE project of FET-OPEN-01-2016-2017. Here a dual-dipole coil was designed for hydrogen MRI at 7 tesla (300 MHz), which outperformed the state-of-the-art setup of the loop-dipole coil for MRI. The new design is transparent to loop designs, meaning that the setup can be combined with loop coils, which are known to be the optimal setup for low frequency operation. So for DMI, which operates at 45.7 MHz (low frequency) at 7 tesla, an MRI coil array can be designed that not only outperforms MRI, but also enables DMI at uncompromised sensitivity within the same scan session, which will complement the utilization of the MCUBE project.

The objectives of the project are: (1) Build and test a body DMI setup for a clinical ultra-high field 7 tesla MRI scanner; (2) demonstrate proof of concept to measure hepatic carbohydrate and lipid metabolism with DMI; and (3) apply DMI in a clinical feasibility study in type 2 diabetes patients. Upon successful completion of the project, DMI will be valorized by the commercial partners and embedded in clinical practice, which opens up a new window for drug studies to directly image their chemical efficacy. Besides its application in metabolic diseases, DMI has potential to detect organ failure, drug toxicity and effects of cancer treatment in a much earlier stage than morphological imaging.

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The information about "BODYDMI" are provided by the European Opendata Portal: CORDIS opendata.

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