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BodyDMI SIGNED

Development of deuterium metabolic imaging to map body biochemistry with MRI

Total Cost €

EC-Contrib. €

Partnership

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BodyDMI project word cloud

Explore the words cloud of the BodyDMI project. It provides you a very rough idea of what is the project "BodyDMI" about.

clinical deuterium frequency imaging image mode stage dramatic attributed idea 45 carbohydrate 3d feasibility therapies spectroscopic successful magnetic transparent arguably resonance morphological tesla invasive ed efficacy opens setup outperformed optimal commercial lagged operates valorized scanner lack toxicity dmi ultra compounds hepatic detect organ 2017 humans epidemic designed dynamically complement mcube completion designs obesity disturbances map operation coils techniques array uncompromised diseases loop 300 oral patients dual treatment chemical outperforms metabolism labeled 01 session earlier 2016 coil global lipid combined mhz metabolic scan sensitivity relies cancer besides drug hydrogen innovation diabetes dynamic dipole body biochemistry fet mri administration window linked proof

Project "BodyDMI" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	100˙000 €
EC max contribution	100˙000 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2018-2019-2020-03
Funding Scheme	CSA
Starting year	2019
Duration (year-month-day)	from 2019-06-01 to 2020-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	81˙250.00
2	WAVETRONICA BV WAVETRONICA BV Organization address address: PADUALAAN 8 ROOM Z109 city: UTRECHT postcode: 3584 CH website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	18˙750.00
3	MR COILS BV MR COILS BV Organization address address: SHIMMINCK 18 city: ZALTBOMMEL postcode: 5301 KR website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ZALTBOMMEL)	participant	0.00

Map

Project objective

The global obesity epidemic has resulted in a dramatic rise in metabolic diseases and the development of effective therapies has greatly lagged behind. This could arguably be attributed to a lack of non-invasive (imaging) techniques to characterize disturbances in metabolic pathways. We will investigate the use of dynamic deuterium metabolic imaging (DMI) to dynamically map body biochemistry in humans in 3D imaging mode. DMI relies on deuterium magnetic resonance spectroscopic imaging combined with oral administration of deuterium-labeled compounds.

The innovation idea is linked to the MCUBE project of FET-OPEN-01-2016-2017. Here a dual-dipole coil was designed for hydrogen MRI at 7 tesla (300 MHz), which outperformed the state-of-the-art setup of the loop-dipole coil for MRI. The new design is transparent to loop designs, meaning that the setup can be combined with loop coils, which are known to be the optimal setup for low frequency operation. So for DMI, which operates at 45.7 MHz (low frequency) at 7 tesla, an MRI coil array can be designed that not only outperforms MRI, but also enables DMI at uncompromised sensitivity within the same scan session, which will complement the utilization of the MCUBE project.

The objectives of the project are: (1) Build and test a body DMI setup for a clinical ultra-high field 7 tesla MRI scanner; (2) demonstrate proof of concept to measure hepatic carbohydrate and lipid metabolism with DMI; and (3) apply DMI in a clinical feasibility study in type 2 diabetes patients. Upon successful completion of the project, DMI will be valorized by the commercial partners and embedded in clinical practice, which opens up a new window for drug studies to directly image their chemical efficacy. Besides its application in metabolic diseases, DMI has potential to detect organ failure, drug toxicity and effects of cancer treatment in a much earlier stage than morphological imaging.

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