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SIMICA SIGNED

Site-selective protein-modification chemistries for antibody-drug conjugates (ADCs)

Total Cost €

EC-Contrib. €

Partnership

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SIMICA project word cloud

Explore the words cloud of the SIMICA project. It provides you a very rough idea of what is the project "SIMICA" about.

excellence constructing sustain sustainability spatial entrepreneurial designing leverage upcoming cementing creation protein communication international internationally training innovation igniting completion exposure conjugates capacity cemented collaborations mentoring community claiming chemically quantifiable simica position integrate business terminus temporal clustering opportunity generation competitive innovative twinning entire drug treatment beneficial circle science sustainable strategy centred cancer lisbon ecosystem students scientific region health rely site stakeholders area serious public young spirit building capability network imm staff networks actions successful portugal compete

Project "SIMICA" data sheet

The following table provides information about the project.

Coordinator	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	800˙000 €
EC max contribution	800˙000 € (100%)
Programme	1. H2020-EU.4.b. (Twinning of research institutions)
Code Call	H2020-WIDESPREAD-2018-03
Funding Scheme	CSA
Starting year	2019
Duration (year-month-day)	from 2019-10-01 to 2022-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	350˙000.00
2	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	190˙000.00
3	PERCUROS BV PERCUROS BV Organization address address: PLESMANLAAN 1 city: LEIDEN postcode: 2333 BZ website: www.percuros.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	165˙000.00
4	ALLCYTE GMBH ALLCYTE GMBH Organization address address: VIENNA BIOCENTER 5 city: WIEN postcode: 1030 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	60˙000.00
5	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	35˙000.00

Map

Project objective

SIMICA will provide IMM with the opportunity to integrate the European circle of research excellence institutions by cementing a sustainable science, technology and innovation network with internationally-leading organisations in the field of protein drug-conjugates. The strategy of SIMICA is based on science- and innovation-driven clustering, and is focused on the exciting and upcoming area of designing and constructing the next generation of chemically-defined and innovative protein drug-conjugates for the targeted treatment of serious conditions such as cancer. The project will allow: i) strengthening the science and technology capacity of IMM and ii) leverage its research excellence and value creation through innovation with a beneficial and quantifiable impact for the entire research and development community at IMM, the Lisbon region and Portugal. The successful implementation of this strategy will rely on specific actions, including: 1) cementing of existing and the creation of new scientific, innovative and technical collaborations through short-term staff exchanges and short-term on-site training activities; 2) training, mentoring and international exposure of IMM’s young researchers and students; 3) building an innovation ecosystem centred at IMM; 4) igniting the entrepreneurial spirit among IMM’s research community; 5) increasing science awareness among the general public through targeted dissemination and communication activities; and 6) developing a sustainability strategy to sustain the cemented network beyond project terminus. Through the completion of these activities, IMM, supported by its twinning partners, is in the best temporal and spatial position to achieve an improved capability to compete for internationally competitive research funding and to access business stakeholders. By claiming its position in research and innovation networks IMM will effectively contribute to research excellence and value creation in health at European level.

Publications

List of publications.
year	authors and title	journal	last update
2016	HÃ©lio Faustino, Maria J. S. A. Silva, LuÃs F. Veiros, GonÃ§alo J. L. Bernardes, Pedro M. P. Gois Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation published pages: 5052-5058, ISSN: 2041-6520, DOI: 10.1039/c6sc01520d	Chemical Science 7/8	2020-02-03
2017	P. Maturana, M. Martinez, M.E. Noguera, N.C. Santos, E.A. Disalvo, L. Semorile, P.C. Maffia, A. Hollmann Lipid selectivity in novel antimicrobial peptides: Implication on antimicrobial and hemolytic activity published pages: 152-159, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2017.02.003	Colloids and Surfaces B: Biointerfaces 153	2020-02-03
2018	Bernadette Lee, Shuang Sun, Ester JimÃ©nez-Moreno, AndrÃ© A. Neves, GonÃ§alo J.L. Bernardes Site-selective installation of an electrophilic handle on proteins for bioconjugation published pages: 3060-3064, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2018.02.028	Bioorganic & Medicinal Chemistry 26/11	2020-02-03
2018	Natacha Couto, Leonard Schuele, Erwin C. Raangs, Miguel P. Machado, Catarina I. Mendes, Tiago F. Jesus, Monika Chlebowicz, Sigrid Rosema, MÃ¡rio Ramirez, JoÃ£o A. CarriÃ§o, Ingo B. Autenrieth, Alex W. Friedrich, Silke Peter, John W. Rossen Critical steps in clinical shotgun metagenomics for the concomitant detection and typing of microbial pathogens published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-31873-w	Scientific Reports 8/1	2020-02-03
2017	Max J. H. Worthington, Renata L. Kucera, InÃªs S. Albuquerque, Christopher T. Gibson, Alexander Sibley, Ashley D. Slattery, Jonathan A. Campbell, Salah F. K. Alboaiji, Katherine A. Muller, Jason Young, Nick Adamson, Jason R. Gascooke, Deshetti Jampaiah, Ylias M. Sabri, Suresh K. Bhargava, Samuel J. Ippolito, David A. Lewis, Jamie S. Quinton, Amanda V. Ellis, Alexander Johs, GonÃ§alo J. L. Bernarde Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils published pages: 16219-16230, ISSN: 0947-6539, DOI: 10.1002/chem.201702871	Chemistry - A European Journal 23/64	2020-02-03
2016	Padma Akkapeddi, Saara-Anne Azizi, Allyson M. Freedy, Pedro M. S. D. Cal, Pedro M. P. Gois, GonÃ§alo J. L. Bernardes Construction of homogeneous antibodyâ€“drug conjugates using site-selective protein chemistry published pages: 2954-2963, ISSN: 2041-6520, DOI: 10.1039/c6sc00170j	Chemical Science 7/5	2020-02-03
2018	Shuang Sun, Ismael CompaÃ±Ã³n, Nuria MartÃnez-SÃ¡ez, JoÃ£o D. Seixas, Omar Boutureira, Francisco Corzana, GonÃ§alo J. L. Bernardes Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides published pages: 48-52, ISSN: 1439-4227, DOI: 10.1002/cbic.201700586	ChemBioChem 19/1	2020-02-03
2018	Pinto, Sandra N.; Dias, Susana Almeida; Cruz, Ana F.; Mil-Homens, Dalila; Fernandes, Fabio; Valle, Javier; Andreu, David; Prieto, Manuel; Castanho, Miguel; Coutinho, Ana; Veiga, Ana Salome Activity of the viral-derived peptide pepR against Staphylococcus aureus biofilms and insights into the mechanism of action published pages: , ISSN: , DOI:	JOURNAL OF PEPTIDE SCIENCE	2020-02-03
2018	Filipa Rijo-Ferreira, TÃ¢nia Carvalho, Cristina Afonso, Margarida Sanches-Vaz, Rui M Costa, LuÃsa M. Figueiredo, Joseph S. Takahashi Sleeping sickness is a circadian disorder published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02484-2	Nature Communications 9/1	2020-02-03
2016	Maria Rebelo, Thomas HÃ¤nscheid Flow Cytometry for Antimalarial Drug Testing: More than Meets the Eye published pages: 817-817, ISSN: 0095-1137, DOI: 10.1128/jcm.03017-15	Journal of Clinical Microbiology 54/3	2020-02-03
2018	Akiko Noma, Carlas S. Smith, Maximiliaan Huisman, Robert M. Martin, Melissa J. Moore, David Grunwald Advanced 3D Analysis and Optimization of Single-Molecule FISH in Drosophila Muscle published pages: 1700324, ISSN: 2366-9608, DOI: 10.1002/smtd.201700324	Small Methods 2/9	2020-02-03
2016	Ricardo Ferraz, Joana Noronha, Fernanda Murtinheira, FÃ¡tima Nogueira, Marta Machado, Miguel PrudÃªncio, Silvia Parapini, Sarah D\'Alessandro, CÃ¡tia Teixeira, Ana Gomes, Cristina PrudÃªncio, Paula Gomes Primaquine-based ionic liquids as a novel class of antimalarial hits published pages: 56134-56138, ISSN: 2046-2069, DOI: 10.1039/c6ra10759a	RSC Advances 6/61	2020-02-03
2016	Sandra Casimiro, Arlindo Ferreira, AndrÃ© Mansinho, Irina Alho, Luis Costa Molecular Mechanisms of Bone Metastasis: Which Targets Came from the Bench to the Bedside? published pages: 1415, ISSN: 1422-0067, DOI: 10.3390/ijms17091415	International Journal of Molecular Sciences 17/9	2020-02-03
2017	Christine Cruz-Oliveira, Andreza F. Almeida, JoÃ£o M. Freire, Marjolly B. Caruso, Maria A. Morando, Vivian N. S. Ferreira, Iranaia AssunÃ§Ã£o-Miranda, Andre M. O. Gomes, Miguel A. R. B. Castanho, Andrea T. Da Poian Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX published pages: , ISSN: 0066-4804, DOI: 10.1128/aac.00053-17	Antimicrobial Agents and Chemotherapy 61/6	2020-02-03
2016	C Bentow, G Lakos, P Martis, E Wahl, M Garcia, O ViÃ±as, G Espinosa, R Cervera, C SjÃ¶wall, D Carmona-Fernandes, M J Santos, J G Hanly, M Mahler International multi-center evaluation of a novel chemiluminescence assay for the detection of anti-dsDNA antibodies published pages: 864-872, ISSN: 0961-2033, DOI: 10.1177/0961203316640917	Lupus 25/8	2020-02-03
2018	Tiago N. Figueira, Diogo A. MendonÃ§a, Diana Gaspar, Manuel N. Melo, Anne Moscona, Matteo Porotto, Miguel A. R. B. Castanho, Ana SalomÃ© Veiga Structureâ€“Stabilityâ€“Function Mechanistic Links in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles published pages: 9855-9865, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b01422	ACS Nano 12/10	2020-02-03
2017	Omar Boutureira, Nuria MartÃnez-SÃ¡ez, Kevin M. Brindle, AndrÃ© A. Neves, Francisco Corzana, GonÃ§alo J. L. Bernardes Site-Selective Modification of Proteins with Oxetanes published pages: 6483-6489, ISSN: 0947-6539, DOI: 10.1002/chem.201700745	Chemistry - A European Journal 23/27	2020-02-03
2017	Raquel Azevedo, Marija Markovic, Marta Machado, Blandine Franke-Fayard, AntÃ³nio M. Mendes, Miguel PrudÃªncio Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds published pages: , ISSN: 0066-4804, DOI: 10.1128/aac.02699-16	Antimicrobial Agents and Chemotherapy 61/6	2020-02-03
2016	Correia, J.; Gano, L.; Santos, I.; Serrano, I. D.; Santos, S.; Ribeiro, M.; Perazzo, J.; Tavares, I.; Heras, M.; Bardaji, E.; Castanho, M. A.; Oliveira, M. C. BIOLOGICAL EVALUATION OF RADIOIODINATED AMIDATED KYOTORPHIN published pages: , ISSN: , DOI:	JOURNAL OF PEPTIDE SCIENCE	2020-02-03
2017	Sousa C. F., Coimbra J. T. S., Gomes I., Franco R., Fernandes P. A., Gameiro P. The binding of free and copper-complexed fluoroquinolones to OmpF porins: an experimental and molecular docking study published pages: 10009-10019, ISSN: 2046-2069, DOI: 10.1039/c6ra26466b	RSC Advances 7/17	2020-02-03
2018	Rita Capela, Joana MagalhÃ£es, Daniela Miranda, Marta Machado, Margarida Sanches-Vaz, InÃªs S. Albuquerque, Moni Sharma, Jiri Gut, Philip J. Rosenthal, Raquel Frade, Maria J. Perry, Rui Moreira, Miguel PrudÃªncio, Francisca Lopes Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability published pages: 69-78, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2018.02.048	European Journal of Medicinal Chemistry 149	2020-02-03
2017	Nuria MartÃnez-SÃ¡ez, Shuang Sun, Davide Oldrini, Pietro Sormanni, Omar Boutureira, Filippo Carboni, Ismael CompaÃ±Ã³n, Michael J. Deery, Michele Vendruscolo, Francisco Corzana, Roberto Adamo, GonÃ§alo J. L. Bernardes Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity Inâ€…Vivo published pages: 14963-14967, ISSN: 1433-7851, DOI: 10.1002/anie.201708847	Angewandte Chemie International Edition 56/47	2020-02-03
2016	A. S. Ribeiro, F. A. Carvalho, J. Figueiredo, R. Carvalho, T. Mestre, J. Monteiro, A. F. Guedes, M. Fonseca, J. Sanches, R. Seruca, N. C. Santos, J. Paredes Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells published pages: 19390-19401, ISSN: 2040-3364, DOI: 10.1039/c6nr04465d	Nanoscale 8/46	2020-02-03
2018	Eva Cunha, Tiago TrovÃ£o, Ana Pinheiro, Telmo Nunes, Raquel Santos, Jorge Moreira da Silva, Berta SÃ£o Braz, LuÃs Tavares, Ana SalomÃ© Veiga, Manuela Oliveira Potential of two delivery systems for nisin topical application to dental plaque biofilms in dogs published pages: , ISSN: 1746-6148, DOI: 10.1186/s12917-018-1692-9	BMC Veterinary Research 14/1	2020-02-03
2018	Maria J. Matos, Bruno L. Oliveira, Nuria MartÃnez-SÃ¡ez, Ana Guerreiro, Pedro M. S. D. Cal, Jean Bertoldo, MarÃa Maneiro, Elizabeth Perkins, Julie Howard, Michael J. Deery, Justin M. Chalker, Francisco Corzana, Gonzalo JimÃ©nez-OsÃ©s, GonÃ§alo J. L. Bernardes Chemo- and Regioselective Lysine Modification on Native Proteins published pages: 4004-4017, ISSN: 0002-7863, DOI: 10.1021/jacs.7b12874	Journal of the American Chemical Society 140/11	2020-02-03
2018	Andreia N. HorÃ¡cio, Catarina Silva-Costa, ElÃsia Lopes, MÃ¡rio Ramirez, JosÃ© Melo-Cristino Conjugate vaccine serotypes persist as major causes of non-invasive pneumococcal pneumonia in Portugal despite declines in serotypes 3 and 19A (2012-2015) published pages: e0206912, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0206912	PLOS ONE 13/11	2020-02-03
2018	Bernardes, Goncalo Building linkerless ADCs and CO-releasing antibodies for cancer therapeutics published pages: , ISSN: , DOI:	ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY	2020-02-03
2016	Bruno L. Oliveira, Zijian Guo, Omar Boutureira, Ana Guerreiro, Gonzalo JimÃ©nez-OsÃ©s, GonÃ§alo J. L. Bernardes A Minimal, Unstrained S-Allyl Handle for Pre-Targeting Diels-Alder Bioorthogonal Labeling in Live Cells published pages: 14683-14687, ISSN: 1433-7851, DOI: 10.1002/anie.201608438	Angewandte Chemie International Edition 55/47	2020-02-03
2016	TAÃS S. MACEDO, LEGNA COLINA-VEGAS, MARCELO DA PAIXÃƒO, MARIBEL NAVARRO, BRENO C. BARRETO, POLIANA C.Â M. OLIVEIRA, SIMONE G. MACAMBIRA, MARTA MACHADO, MIGUEL PRUDÃŠNCIO, SARAH D\'ALESSANDRO, NICOLETTA BASILICO, DIOGO R.Â M. MOREIRA, ALZIR A. BATISTA, MILENA B.Â P. SOARES Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents published pages: 1543-1556, ISSN: 0031-1820, DOI: 10.1017/s0031182016001153	Parasitology 143/12	2020-02-03
2016	Carlos J.A. Ribeiro, Margarida Espadinha, Marta Machado, Jiri Gut, LÃdia M. GonÃ§alves, Philip J. Rosenthal, Miguel PrudÃªncio, Rui Moreira, Maria M.M. Santos Novel squaramides with in vitro liver stage antiplasmodial activity published pages: 1786-1792, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2016.03.005	Bioorganic & Medicinal Chemistry 24/8	2020-02-03
2018	Kristina PaviÄ‡, Ivana PerkoviÄ‡, Å Ã¡rka PospÃÅ¡ilovÃ¡, Marta Machado, Diana Fontinha, Miguel PrudÃªncio, Josef Jampilek, Aidan Coffey, Lorraine Endersen, Hrvoje Rimac, Branka Zorc Primaquine hybrids as promising antimycobacterial and antimalarial agents published pages: 769-779, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.11.083	European Journal of Medicinal Chemistry 143	2020-02-03
2016	Evans, Austin; Crockett, Michael; Worthington, Max; Albuquerque, Ines; Slattery, Ashley; Gibson, Christopher; Lewis, David; Campbell, Jonathan; Bernardes, Goncalo; Chalker, Justin Sulfur-limonene polysulfide: A material synthesized entirely from industrial byproducts and its use in removing toxic metals from water and soil published pages: , ISSN: , DOI:	ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY	2020-02-03
2018	Lucas Robke, Tiago Rodrigues, Peter SchrÃ¶der, Daniel J. Foley, GonÃ§alo J.L. Bernardes, Luca Laraia, Herbert Waldmann Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors published pages: 4531-4537, ISSN: 0040-4020, DOI: 10.1016/j.tet.2018.07.021	Tetrahedron 74/35	2020-02-03
2017	Woo Gyum Kim, Mi Eun Kang, Jae Bin Lee, Min Ho Jeon, Sungmin Lee, Jungha Lee, Bongseo Choi, Pedro M. S. D. Cal, Sebyung Kang, Jung-Min Kee, GonÃ§alo J. L. Bernardes, Jan-Uwe Rohde, Wonyoung Choe, Sung You Hong Nickel-Catalyzed Azideâ€“Alkyne Cycloaddition To Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water published pages: 12121-12124, ISSN: 0002-7863, DOI: 10.1021/jacs.7b06338	Journal of the American Chemical Society 139/35	2020-02-03
2016	Andreia N. HorÃ¡cio, Catarina Silva-Costa, Jorge Diamantino-Miranda, Joana P. Lopes, Mario Ramirez, JosÃ© Melo-Cristino Population Structure of Streptococcus pneumoniae Causing Invasive Disease in Adults in Portugal before PCV13 Availability for Adults: 2008-2011 published pages: e0153602, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0153602	PLOS ONE 11/5	2020-02-03
2017	Marcelo T. Augusto, Axel Hollmann, Fulvia Troise, Ana S. Veiga, Antonello Pessi, Nuno C. Santos Lipophilicity is a key factor to increase the antiviral activity of HIV neutralizing antibodies published pages: 311-316, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2017.01.032	Colloids and Surfaces B: Biointerfaces 152	2020-02-03
2016	Adam Armada-Moreira, Essi TaipaleenmÃ¤ki, Fabian Itel, Yan Zhang, Brigitte StÃ¤dler Droplet-microfluidics towards the assembly of advanced building blocks in cell mimicry published pages: 19510-19522, ISSN: 2040-3364, DOI: 10.1039/c6nr07807a	Nanoscale 8/47	2020-02-03
2018	Felicio, Mario R.; Franco, Octavio; Santos, Nuno C.; Goncalves, Snia PaMAP 1.9 and PaMAP 2: efficient multi-resistant antimicrobial peptides show evidence of anticancer activity published pages: , ISSN: , DOI:	JOURNAL OF PEPTIDE SCIENCE	2020-02-03
2016	Axel Hollmann, Melina MartÃnez, MartÃn E. Noguera, Marcelo T. Augusto, Anibal Disalvo, Nuno C. Santos, Liliana Semorile, Paulo C. MaffÃa Role of amphipathicity and hydrophobicity in the balance between hemolysis and peptideâ€“membrane interactions of three related antimicrobial peptides published pages: 528-536, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2016.02.003	Colloids and Surfaces B: Biointerfaces 141	2020-02-03
2018	Tiago Rodrigues, GonÃ§alo J. L. Bernardes Development of Antibody-Directed Therapies: Quo Vadis ? published pages: 2032-2034, ISSN: 1433-7851, DOI: 10.1002/anie.201712185	Angewandte Chemie International Edition 57/8	2020-02-03
2018	Perez-Peinado, Clara; Almeida Dias, Susana; Domingues, Marco M.; Benfield, Aurelie H.; Miguel Freire, Jodo; Radis-Baptista, Gandhi; Gaspar, Diana; Castanho, Miguel; Craik, David; Henriques, Sonia Troeira; Salome Veiga, Ana; Andreu, David Mechanisms of bacterial membrane permeabilization of snake venom-derived peptides crotalicidin (Ctn) and Ctn[15-34] published pages: , ISSN: , DOI:	JOURNAL OF PEPTIDE SCIENCE	2020-02-03
2017	Ricardo Santâ€™Anna, Maria RosÃ¡rio Almeida, Nathalia VarejÄo, Pablo Gallego, Sebastian Esperante, Priscila Ferreira, Alda Pereira-Henriques, Fernando L. Palhano, Mamede de Carvalho, Debora Foguel, David Reverter, Maria JoÃ£o Saraiva, Salvador Ventura Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation published pages: , ISSN: 2045-2322, DOI: 10.1038/srep44709	Scientific Reports 7/1	2020-02-03
2017	Tiago N. Figueira, Filipa D. Oliveira, InÃªs Almeida, Ã‰rica O. Mello, Valdirene M. Gomes, Miguel A. R. B. Castanho, Diana Gaspar Challenging metastatic breast cancer with the natural defensin Pv D 1 published pages: 16887-16899, ISSN: 2040-3364, DOI: 10.1039/c7nr05872a	Nanoscale 9/43	2020-02-03
2017	VÃctor J. Somovilla, Iris A. Bermejo, InÃªs S. Albuquerque, Nuria MartÃnez-SÃ¡ez, Jorge Castro-LÃ³pez, Fayna GarcÃa-MartÃn, Ismael CompaÃ±Ã³n, Hiroshi Hinou, Shin-Ichiro Nishimura, JesÃºs JimÃ©nez-Barbero, Juan L. Asensio, Alberto Avenoza, JesÃºs H. Busto, RamÃ³n Hurtado-Guerrero, JesÃºs M. Peregrina, GonÃ§alo J. L. Bernardes, Francisco Corzana The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer published pages: 18255-18261, ISSN: 0002-7863, DOI: 10.1021/jacs.7b09447	Journal of the American Chemical Society 139/50	2020-02-03
2018	Neves, Vera; Aires-Da-Silva, Frederico; Gano, Lurdes; Corte-Real, Sofia; Correia, Joao D. G.; Castanho, Miguel Trans-Blood brain barrier peptides to enhace delivery of therapeutic molecules to treat Alzheimer\'s disease published pages: , ISSN: , DOI:	JOURNAL OF PEPTIDE SCIENCE	2020-02-03
2018	Jelmer Savelkoel, Klaas Hendrik Binnendijk, Rene Spijker, MichÃ¨le van Vugt, Kathrine Tan, Thomas HÃ¤nscheid, Patricia Schlagenhauf, Martin Peter Grobusch Abbreviated atovaquone-proguanil prophylaxis regimens in travellers after leaving malaria-endemic areas: A systematic review published pages: 3-20, ISSN: 1477-8939, DOI: 10.1016/j.tmaid.2017.12.005	Travel Medicine and Infectious Disease 21	2020-02-03
2016	Tiago Rodrigues, Florian Sieglitz, GonÃ§alo J. L. Bernardes Natural product modulators of transient receptor potential (TRP) channels as potential anti-cancer agents published pages: 6130-6137, ISSN: 0306-0012, DOI: 10.1039/c5cs00916b	Chemical Society Reviews 45/22	2020-02-03
2016	Nuno Rosa, JÃ©ssica Marques, Eduardo Esteves, MÃ³nica Fernandes, Vera M. Mendes, Ã‚ngela Afonso, SÃ©rgio Dias, Joaquim Polido Pereira, Bruno Manadas, Maria JosÃ© Correia, Marlene Barros Protein Quality Assessment on Saliva Samples for Biobanking Purposes published pages: 289-297, ISSN: 1947-5535, DOI: 10.1089/bio.2015.0054	Biopreservation and Biobanking 14/4	2020-02-03
2018	Tiago Rodrigues, Markus Werner, Jakob Roth, Eduardo H. G. da Cruz, Marta C. Marques, Padma Akkapeddi, Susana A. Lobo, Andreas Koeberle, Francisco Corzana, EufrÃ¢nio N. da Silva JÃºnior, Oliver Werz, GonÃ§alo J. L. Bernardes Machine intelligence decrypts Î²-lapachone as an allosteric 5-lipoxygenase inhibitor published pages: 6899-6903, ISSN: 2041-6520, DOI: 10.1039/c8sc02634c	Chemical Science 9/34	2020-02-03
2018	Maja Beus, Zrinka RajiÄ‡, Dusica Maysinger, Zvonimir MlinariÄ‡, Maja AntunoviÄ‡, Inga MarijanoviÄ‡, Diana Fontinha, Miguel PrudÃªncio, Jana Held, Sureyya Olgen, Branka Zorc SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents published pages: 624-638, ISSN: 2191-1363, DOI: 10.1002/open.201800117	ChemistryOpen 7/8	2020-02-03
2016	Andreia N. HorÃ¡cio, Catarina Silva-Costa, Joana P. Lopes, MÃ¡rio Ramirez, JosÃ© Melo-Cristino Serotype 3 Remains the Leading Cause of Invasive Pneumococcal Disease in Adults in Portugal (2012â€“2014) Despite Continued Reductions in Other 13-Valent Conjugate Vaccine Serotypes published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2016.01616	Frontiers in Microbiology 7	2020-02-03
2016	GonÃ§alo C. Justino, Pedro F. Pinheiro, Alexandra P. S. Roseiro, Ana S. O. Knittel, JoÃ£o GonÃ§alves, Marta C. Justino, M. Fernanda N. N. Carvalho Camphor-based CCR5 blocker lead compounds â€“ a computational and experimental approach published pages: 56249-56259, ISSN: 2046-2069, DOI: 10.1039/c6ra09627a	RSC Advances 6/61	2020-02-03
2017	Terence T.-L. Kwan, Omar Boutureira, Elizabeth C. Frye, Stephen J. Walsh, Moni K. Gupta, Stephen Wallace, Yuteng Wu, Fengzhi Zhang, Hannah F. Sore, Warren R. J. D. Galloway, Jason W. Chin, Martin Welch, GonÃ§alo J. L. Bernardes, David R. Spring Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium( ii ) catalyst published pages: 3871-3878, ISSN: 2041-6520, DOI: 10.1039/c6sc05313k	Chemical Science 8/5	2020-02-03
2016	Wesley C. Van Voorhis, John H. Adams, Roberto Adelfio, Vida Ahyong, Myles H. Akabas, Pietro Alano, Aintzane Alday, Yesmalie AlemÃ¡n Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T. Andrews, Simon V. Avery, Vicky M. Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, JÃ¼rgen Bosch, Lauren E. Boucher, Fabrice F. B Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond published pages: e1005763, ISSN: 1553-7366, DOI: 10.1371/journal.ppat.1005763	PLOS Pathogens 12/7	2020-02-03
2018	StÄ™pieÅ„ E, Marina C Costa, Szczepan Kurc, Anna DroÅ¼dÅ¼, Nuno Cortez-Dias, Francisco J Enguita The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases published pages: 1085-1099, ISSN: 1671-4083, DOI: 10.1038/aps.2018.35	Acta Pharmacologica Sinica 39/7	2020-02-03
2016	Terzic, Natasa; Konstantinovic, Jelena; Tot, Miklos; Burojevic, Jovana; Djurkovic-Djakovic, Olgica; Srbljanovic, Jelena; Stajner, Tijana; Verbic, Tatjana; Zlatovic, Mario; Machado, Marta; Albuquerque, Ines S.; Prudencio, Miguel; Sciotii, Richard J.; Pecic, Stevan; D\'Alessandro, Sarah; Taramelli, Donatella; Solaja, Bogdan A. Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials? published pages: , ISSN: 0022-2623, DOI:	JOURNAL OF MEDICINAL CHEMISTRY	2020-02-03
2018	Miguel Peixoto de Almeida, Pedro Quaresma, Susana Sousa, ClÃ¡udia Couto, InÃªs Gomes, Ludwig Krippahl, Ricardo Franco, EulÃ¡lia Pereira Measurement of adsorption constants of laccase on gold nanoparticles to evaluate the enhancement in enzyme activity of adsorbed laccase published pages: 16761-16769, ISSN: 1463-9076, DOI: 10.1039/c8cp03116a	Physical Chemistry Chemical Physics 20/24	2020-02-03
2017	Pedro M. S. D. Cal, Maria J. Matos, GonÃ§alo J. L. Bernardes Trends in therapeutic drug conjugates for bacterial diseases: a patent review published pages: 179-189, ISSN: 1354-3776, DOI: 10.1080/13543776.2017.1259411	Expert Opinion on Therapeutic Patents 27/2	2020-02-03
2017	M.L. Pinto, E. Rios, A.C. Silva, S.C. Neves, H.R. Caires, A.T. Pinto, C. DurÃ£es, F.A. Carvalho, A.P. Cardoso, N.C. Santos, C.C. Barrias, D.S. Nascimento, P. Pinto-do-Ã“, M.A. Barbosa, F. Carneiro, M.J. Oliveira Decellularized human colorectal cancer matrices polarize macrophages towards an anti-inflammatory phenotype promoting cancer cell invasion via CCL18 published pages: 211-224, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.02.004	Biomaterials 124	2020-02-03
2017	JoÃ£o Lopes, David Alves, TÃ¢nia S. Morais, Paulo J. Costa, M. FÃ¡tima M. Piedade, Fernanda Marques, Maria J. Villa de Brito, M. Helena Garcia New copper(I) and heteronuclear copper(I)â€“ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity published pages: 68-78, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2017.01.007	Journal of Inorganic Biochemistry 169	2020-02-03
2016	Osmar N. Silva, Eliane S. F. Alves, CÃ©sar de la Fuente-NÃºÃ±ez, Suzana M. Ribeiro, Santi M. Mandal, Diana Gaspar, Ana S. Veiga, Miguel A. R. B. Castanho, Cesar A. S. Andrade, Jessica M. Nascimento, Isabel C. M. Fensterseifer, William F. Porto, Jose R. Correa, Robert. E. W. Hancock, Suresh Korpole, Aline L. Oliveira, Luciano M. Liao, Octavio L. Franco Structural Studies of a Lipid-Binding Peptide from Tunicate Hemocytes with Anti-Biofilm Activity published pages: , ISSN: 2045-2322, DOI: 10.1038/srep27128	Scientific Reports 6/1	2020-02-03
2018	Ana Armada-Moreira, Bo Thingholm, Kristine Andreassen, Ana M. SebastiÃ£o, Sandra H. Vaz, Brigitte StÃ¤dler On the Assembly of Microreactors with Parallel Enzymatic Pathways published pages: 1700244, ISSN: 2366-7478, DOI: 10.1002/adbi.201700244	Advanced Biosystems 2/5	2020-02-03
2016	Tiago Rodrigues, Florian Sieglitz, VÃctor J. Somovilla, Pedro M. S. D. Cal, Antony Galione, Francisco Corzana, GonÃ§alo J. L. Bernardes Unveiling (âˆ’)-Englerinâ€…A as a Modulator of L-Type Calcium Channels published pages: 11077-11081, ISSN: 1433-7851, DOI: 10.1002/anie.201604336	Angewandte Chemie International Edition 55/37	2020-02-03
2018	Thais P. Pivetta, Sandra SimÃµes, Margarete M. AraÃºjo, TÃ¢nia Carvalho, Caroline Arruda, Priscyla D. Marcato Development of nanoparticles from natural lipids for topical delivery of thymol: Investigation of its anti-inflammatory properties published pages: 281-290, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2018.01.053	Colloids and Surfaces B: Biointerfaces 164	2020-02-03
2017	Ana F. Guedes, Filomena A. Carvalho, Carlos Moreira, JosÃ© B. Nogueira, Nuno C. Santos Essential arterial hypertension patients present higher cell adhesion forces, contributing to fibrinogen-dependent cardiovascular risk published pages: 14897-14906, ISSN: 2040-3364, DOI: 10.1039/c7nr03891g	Nanoscale 9/39	2020-02-03
2017	Allyson M. Freedy, Maria J. Matos, Omar Boutureira, Francisco Corzana, Ana Guerreiro, Padma Akkapeddi, VÃctor J. Somovilla, Tiago Rodrigues, Karl Nicholls, Bangwen Xie, Gonzalo JimÃ©nez-OsÃ©s, Kevin M. Brindle, AndrÃ© A. Neves, GonÃ§alo J. L. Bernardes Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation published pages: 18365-18375, ISSN: 0002-7863, DOI: 10.1021/jacs.7b10702	Journal of the American Chemical Society 139/50	2020-02-03
2016	Elena M. SÃ¡nchez FernÃ¡ndez, Claudio D. Navo, Nuria MartÃnez-SÃ¡ez, Rita GonÃ§alves-Pereira, VÃctor J. Somovilla, Alberto Avenoza, JesÃºs H. Busto, GonÃ§alo J. L. Bernardes, Gonzalo JimÃ©nez-OsÃ©s, Francisco Corzana, JosÃ© M. GarcÃa FernÃ¡ndez, Carmen Ortiz Mellet, JesÃºs M. Peregrina Tn Antigen Mimics Based on sp 2 -Iminosugars with Affinity for an anti-MUC1 Antibody published pages: 3890-3893, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b01899	Organic Letters 18/15	2020-02-03
2018	Benjamin J. Stenton, Bruno L. Oliveira, Maria J. Matos, Laura Sinatra, GonÃ§alo J. L. Bernardes A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging published pages: 4185-4189, ISSN: 2041-6520, DOI: 10.1039/c8sc00256h	Chemical Science 9/17	2020-02-03
2018	Carlos AV Rodrigues, Teresa P Silva, Diogo ES Nogueira, Tiago G Fernandes, Yas Hashimura, Robin Wesselschmidt, Maria Margarida Diogo, Brian Lee, Joaquim MS Cabral Scalable culture of human induced pluripotent cells on microcarriers under xeno-free conditions using single-use vertical-wheelâ„¢ bioreactors published pages: 3597-3606, ISSN: 0268-2575, DOI: 10.1002/jctb.5738	Journal of Chemical Technology & Biotechnology 93/12	2020-02-03
2017	Goreti Ribeiro Morais, Elisa Palma, Fernanda Marques, Lurdes Gano, Maria Cristina Oliveira, Antero Abrunhosa, Hugo Vicente Miranda, Tiago F. Outeiro, Isabel Santos, Antonio Paulo Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents published pages: 255-267, ISSN: 0022-152X, DOI: 10.1002/jhet.2575	Journal of Heterocyclic Chemistry 54/1	2020-02-03
2017	Tiago Rodrigues Harnessing the potential of natural products in drug discovery from a cheminformatics vantage point published pages: 9275-9282, ISSN: 1477-0520, DOI: 10.1039/c7ob02193c	Organic & Biomolecular Chemistry 15/44	2020-02-03
2018	PatrÃcia M. Carvalho, MÃ¡rio R. FelÃcio, Nuno C. Santos, SÃ³nia GonÃ§alves, Marco M. Domingues Application of Light Scattering Techniques to Nanoparticle Characterization and Development published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2018.00237	Frontiers in Chemistry 6	2020-02-03
2017	Pedro M. S. D. Cal, Florian Sieglitz, FÃ¡bio M. F. Santos, CÃ¡tia Parente Carvalho, Ana Guerreiro, Jean B. Bertoldo, Uwe Pischel, Pedro M. P. Gois, GonÃ§alo J. L. Bernardes Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells published pages: 368-371, ISSN: 1359-7345, DOI: 10.1039/c6cc08671c	Chemical Communications 53/2	2020-02-03
2017	Pedro D. Pereira, Ana Serra-Caetano, Marisa Cabrita, Evguenia Bekman, JosÃ© Braga, JosÃ© Rino, RenÃ¨ Santus, Paulo L. Filipe, Ana E. Sousa, JoÃ£o A. Ferreira \"Quantification of cell cycle kinetics by EdU (5-ethynyl-2′-deoxyuridine)-coupled-fluorescence-intensity analysis\" published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.17121	Oncotarget 8/25	2020-02-03
2017	Marcelo Augusto, Axel Hollmann, Matteo Porotto, Anne Moscona, Nuno Santos Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length published pages: 1190, ISSN: 1420-3049, DOI: 10.3390/molecules22071190	Molecules 22/7	2020-02-03
2018	ElÃsia Lopes, TÃ¢nia Fernandes, Miguel P Machado, JoÃ£o AndrÃ© CarriÃ§o, JosÃ© Melo-Cristino, MÃ¡rio Ramirez, Elisabete R Martins Increasing macrolide resistance among Streptococcus agalactiae causing invasive disease in non-pregnant adults was driven by a single capsular-transformed lineage, Portugal, 2009 to 2015 published pages: , ISSN: 1560-7917, DOI: 10.2807/1560-7917.es.2018.23.21.1700473	Eurosurveillance 23/21	2020-02-03
2017	Kawaljit Singh, John Okombo, Christel Brunschwig, Ferdinand Ndubi, Linley Barnard, Chad Wilkinson, Peter M. Njogu, Mathew Njoroge, Lizahn Laing, Marta Machado, Miguel PrudÃªncio, Janette Reader, Mariette Botha, Sindisiwe Nondaba, Lyn-Marie Birkholtz, Sonja Lauterbach, Alisje Churchyard, Theresa L. Coetzer, Jeremy N. Burrows, Clive Yeates, Paolo Denti, Lubbe Wiesner, Timothy J. Egan, Sergio Wittlin Antimalarial Pyrido[1,2- a ]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model published pages: 1432-1448, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01641	Journal of Medicinal Chemistry 60/4	2020-02-03
2017	Gonzalo Scalese, M. Florencia Mosquillo, Santiago RostÃ¡n, Jorge Castiglioni, Irina Alho, Leticia PÃ©rez, Isabel Correia, Fernanda Marques, JoÃ£o Costa Pessoa, Dinorah Gambino Heteroleptic oxidovanadium(IV) complexes of 2-hydroxynaphtylaldimine and polypyridyl ligands against Trypanosoma cruzi and prostate cancer cells published pages: 154-166, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2017.07.014	Journal of Inorganic Biochemistry 175	2020-02-03
2017	Sara Neves-Coelho, Rute EleutÃ©rio, Francisco Enguita, Vera Neves, Miguel Castanho A New Noncanonical Anionic Peptide That Translocates a Cellular Bloodâ€“Brain Barrier Model published pages: 1753, ISSN: 1420-3049, DOI: 10.3390/molecules22101753	Molecules 22/10	2020-02-03
2017	NÃ¡dia Ribeiro, Somnath Roy, Nataliya Butenko, Isabel Cavaco, Teresa Pinheiro, Irina Alho, Fernanda Marques, Fernando Avecilla, JoÃ£o Costa Pessoa, Isabel Correia New Cu(II) complexes with pyrazolyl derived Schiff base ligands: Synthesis and biological evaluation published pages: 63-75, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2017.05.011	Journal of Inorganic Biochemistry 174	2020-02-03
2018	BÃ¡rbara Gomes, SÃ³nia GonÃ§alves, Anibal Disalvo, Axel Hollmann, Nuno C. Santos Effect of 25-hydroxycholesterol in viral membrane fusion: Insights on HIV inhibition published pages: 1171-1178, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2018.02.001	Biochimica et Biophysica Acta (BBA) - Biomembranes 1860/5	2020-02-03
2017	MÃ¡rio R. FelÃcio, Osmar N. Silva, SÃ´nia GonÃ§alves, Nuno C. Santos, OctÃ¡vio L. Franco Peptides with Dual Antimicrobial and Anticancer Activities published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2017.00005	Frontiers in Chemistry 5	2020-02-03
2017	B. L. Oliveira, Z. Guo, G. J. L. Bernardes Inverse electron demand Dielsâ€“Alder reactions in chemical biology published pages: 4895-4950, ISSN: 0306-0012, DOI: 10.1039/c7cs00184c	Chemical Society Reviews 46/16	2020-02-03
2018	BÃ¡rbara Gomes, Marcelo T. Augusto, MÃ¡rio R. FelÃcio, Axel Hollmann, OctÃ¡vio L. Franco, SÃ³nia GonÃ§alves, Nuno C. Santos Designing improved active peptides for therapeutic approaches against infectious diseases published pages: 415-429, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2018.01.004	Biotechnology Advances 36/2	2020-02-03
2018	Sarah Davies, Benjamin J. Stenton, GonÃ§alo J. L. Bernardes Bioorthogonal Decaging Reactions for Targeted Drug Activation published pages: 771-776, ISSN: 0009-4293, DOI: 10.2533/chimia.2018.771	CHIMIA International Journal for Chemistry 72/11	2020-02-03
2016	J. Marto, L.F. Gouveia, L.M. GonÃ§alves, D.P. Gaspar, P. Pinto, F.A. Carvalho, E. Oliveira, H.M. Ribeiro, A.J. Almeida A Quality by design (QbD) approach on starch-based nanocapsules: A promising platform for topical drug delivery published pages: 177-185, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2016.03.039	Colloids and Surfaces B: Biointerfaces 143	2020-02-03
2018	T. N. Figueira, M. T. Augusto, K. Rybkina, D. Stelitano, M. G. Noval, O. E. Harder, A. S. Veiga, D. Huey, C. A. Alabi, S. Biswas, S. Niewiesk, A. Moscona, N. C. Santos, M. A. R. B. Castanho, M. Porotto Effective in Vivo Targeting of Influenza Virus through a Cell-Penetrating/Fusion Inhibitor Tandem Peptide Anchored to the Plasma Membrane published pages: 3362-3376, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00527	Bioconjugate Chemistry 29/10	2020-02-03
2018	Shuang Sun, Bruno L. Oliveira, Gonzalo JimÃ©nez-OsÃ©s, GonÃ§alo J. L. Bernardes Radical-Mediated Thiol-Ene Strategy: Photoactivation of Thiol-Containing Drugs in Cancer Cells published pages: 15832-15835, ISSN: 1433-7851, DOI: 10.1002/anie.201811338	Angewandte Chemie International Edition 57/48	2020-02-03
2016	Miguel A. S. Cavadas, Marco P. Monopoli, ClÃ¡udia SÃ¡ e Cunha, Miguel PrudÃªncio, EulÃ¡lia Pereira, Iseult Lynch, Kenneth A. Dawson, Ricardo Franco Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates published pages: 906-915, ISSN: 0934-0866, DOI: 10.1002/ppsc.201600187	Particle & Particle Systems Characterization 33/12	2020-02-03
2016	Diana Montes-Grajales, GonÃ§alo J. L. Bernardes, Jesus Olivero-Verbel Urban Endocrine Disruptors Targeting Breast Cancer Proteins published pages: 150-161, ISSN: 0893-228X, DOI: 10.1021/acs.chemrestox.5b00342	Chemical Research in Toxicology 29/2	2020-02-03
2018	Maria J. Matos, Carlos LabÃ£o-Almeida, Claire Sayers, Oyinlola Dada, Matthias Tacke, GonÃ§alo J. L. Bernardes *Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC-Au-Albumin and -Trastuzumab Bioconjugates** published pages: 12250-12253, ISSN: 0947-6539, DOI: 10.1002/chem.201800872	Chemistry - A European Journal 24/47	2020-02-03
2018	CÃ¡tia Caneiras, Filipa Calisto, Gabriela Jorge da Silva, Luis Lito, JosÃ© Melo-Cristino, Aida Duarte First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal published pages: 96, ISSN: 2079-6382, DOI: 10.3390/antibiotics7040096	Antibiotics 7/4	2020-02-03
2017	BÃ¡rbara Gomes, Nuno Santos, Matteo Porotto Biophysical Properties and Antiviral Activities of Measles Fusion Protein Derived Peptide Conjugated with 25-Hydroxycholesterol published pages: 1869, ISSN: 1420-3049, DOI: 10.3390/molecules22111869	Molecules 22/11	2020-02-03
2016	Michael P. Crockett, Austin M. Evans, Max J. H. Worthington, InÃªs S. Albuquerque, Ashley D. Slattery, Christopher T. Gibson, Jonathan A. Campbell, David A. Lewis, GonÃ§alo J. L. Bernardes, Justin M. Chalker Sulfur-Limonene Polysulfide: A Material Synthesized Entirely from Industrial By-Products and Its Use in Removing Toxic Metals from Water and Soil published pages: 1714-1718, ISSN: 1433-7851, DOI: 10.1002/anie.201508708	Angewandte Chemie International Edition 55/5	2020-02-03
2016	Nikolaus Krall, Filipa P. da Cruz, Omar Boutureira, GonÃ§alo J. L. Bernardes Site-selective protein-modification chemistry for basic biology and drug development published pages: 103-113, ISSN: 1755-4330, DOI: 10.1038/nchem.2393	Nature Chemistry 8/2	2020-02-03
2018	Marcela Å afratovÃ¡, Anna HoÅ¡Å¥Ã¡lkovÃ¡, Daniela HulcovÃ¡, KateÅ™ina BreiterovÃ¡, Veronika HrabcovÃ¡, Marta Machado, Diana Fontinha, Miguel PrudÃªncio, JiÅ™Ã KuneÅ¡, Jakub Chlebek, Daniel Jun, Martina HrabinovÃ¡, Lucie NovÃ¡kovÃ¡, Radim Havelek, Martina SeifrtovÃ¡, LubomÃr Opletal, Lucie CahlÃkovÃ¡ Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity published pages: 208-218, ISSN: 0253-6269, DOI: 10.1007/s12272-017-1000-4	Archives of Pharmacal Research 41/2	2020-02-03
2017	JoÃ£o Miguel Freire, InÃªs Rego de Figueiredo, Javier Valle, Ana SalomÃ© Veiga, David Andreu, Francisco J. Enguita, Miguel A.R.B. Castanho siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model published pages: 127-136, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2016.11.027	Journal of Controlled Release 245	2020-02-03
2017	Tiago N. Figueira, JoÃ£o M. Freire, Catarina Cunha-Santos, Montserrat Heras, JoÃ£o GonÃ§alves, Anne Moscona, Matteo Porotto, Ana SalomÃ© Veiga, Miguel A. R. B. Castanho Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance published pages: , ISSN: 2045-2322, DOI: 10.1038/srep45647	Scientific Reports 7/1	2020-02-03
2016	Tiago F. Jorge, JoÃ£o A. Rodrigues, Camila Caldana, Romy Schmidt, Joost T. van Dongen, Jane Thomas-Oates, Carla AntÃ³nio Mass spectrometry-based plant metabolomics: Metabolite responses to abiotic stress published pages: 620-649, ISSN: 0277-7037, DOI: 10.1002/mas.21449	Mass Spectrometry Reviews 35/5	2020-02-03
2017	Carlota Saldanha Human Erythrocyte Acetylcholinesterase in Health and Disease published pages: 1499, ISSN: 1420-3049, DOI: 10.3390/molecules22091499	Molecules 22/9	2020-02-03
2017	A. R. Henriques, J. Melo Cristino, M. J. Fraqueza Genetic Characterization of Listeria monocytogenes Isolates from Industrial and Retail Ready-to-Eat Meat-Based Foods and Their Relationship with Clinical Strains from Human Listeriosis in Portugal published pages: 551-560, ISSN: 0362-028X, DOI: 10.4315/0362-028x.jfp-16-310	Journal of Food Protection 80/4	2020-02-03
2017	Annabel Kitowski, Ester JimÃ©nez-Moreno, MÃriam SalvadÃ³, Jordi Mestre, Sergio CastillÃ³n, Gonzalo JimÃ©nez-OsÃ©s, Omar Boutureira, GonÃ§alo J. L. Bernardes Oxidative Activation of Câ€“S Bonds with an Electropositive Nitrogen Promoter Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides published pages: 5490-5493, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b02886	Organic Letters 19/19	2020-02-03
2016	Christopher Leija, Filipa Rijo-Ferreira, Lisa N. Kinch, Nick V. Grishin, Nicole Nischan, Jennifer J. Kohler, Zeping Hu, Margaret A. Phillips Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei published pages: e1006010, ISSN: 1553-7366, DOI: 10.1371/journal.ppat.1006010	PLOS Pathogens 12/11	2020-02-03
2017	Jean B. Bertoldo, Tiago Rodrigues, Lavinia Dunsmore, Francesco A. Aprile, Marta C. Marques, Leonardo A. Rosado, Omar Boutureira, Thomas B. Steinbrecher, Woody Sherman, Francisco Corzana, HernÃ¡n Terenzi, GonÃ§alo J.L. Bernardes A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases published pages: 665-677, ISSN: 2451-9294, DOI: 10.1016/j.chempr.2017.07.009	Chem 3/4	2020-02-03
2017	Jitka DadovÃ¡, Kuan-Jung Wu, Patrick G. Isenegger, James C. Errey, GonÃ§alo J. L. Bernardes, Justin M. Chalker, LluÃs Raich, Carme Rovira, Benjamin G. Davis Precise Probing of Residue Roles by Post-Translational Î²,Î³-C,N Aza-Michael Mutagenesis in Enzyme Active Sites published pages: 1168-1173, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00341	ACS Central Science 3/11	2020-02-03
2018	Alexandra Carreira, JoÃ£o Boavida Ferreira, Iliana Pereira, JoÃ£o Ferreira, Paulo Filipe, Ricardo Boavida Ferreira, Sara Monteiro Blad-containing oligomer: a novel fungicide used in crop protection as an alternative treatment for tinea pedis and tinea versicolor published pages: 198-207, ISSN: 0022-2615, DOI: 10.1099/jmm.0.000675	Journal of Medical Microbiology 67/2	2020-02-03
2018	Makowski, Marcin; Felicio, Mario R.; Franco, Octavio; Goncalves, Sonia; Melo, Manuel N.; Santos, Nuno C. Exploring the membrane activity of a designed antimicrobial peptide with fusogenic properties published pages: , ISSN: , DOI:	JOURNAL OF PEPTIDE SCIENCE	2020-02-03
2016	Diana Lousa, AntÃ³nia R. T. Pinto, Bruno L. Victor, Alessandro Laio, Ana S. Veiga, Miguel A. R. B. Castanho, ClÃ¡udio M. Soares Fusing simulation and experiment: The effect of mutations on the structure and activity of the influenza fusion peptide published pages: , ISSN: 2045-2322, DOI: 10.1038/srep28099	Scientific Reports 6/1	2020-02-03
2018	Jessica G. M. Bevan, Eva C. LourenÃ§o, Miguel Chaves-Ferreira, JoÃ£o A. Rodrigues, M. Rita Ventura Immobilization of UDP-Galactose on an Amphiphilic Resin published pages: 908-914, ISSN: 1434-193X, DOI: 10.1002/ejoc.201701620	European Journal of Organic Chemistry 2018/7	2020-02-03
2018	Ana Filipa Guedes, Filomena A. Carvalho, Marco M. Domingues, Fraser L. Macrae, Helen R. McPherson, Nuno C. Santos, Robert A.S. AriÑ‘ns Sensing adhesion forces between erythrocytes and Î³â€™ fibrinogen, modulating fibrin clot architecture and function published pages: 909-918, ISSN: 1549-9634, DOI: 10.1016/j.nano.2018.01.006	Nanomedicine: Nanotechnology, Biology and Medicine 14/3	2020-02-03
2016	Dejanira Almeida, Elisabete Cristovam, Daniel Caldeira, Joaquim J. Ferreira, Teresa Marques Are there effective interventions to prevent hospital-acquired Legionnaires\' disease or to reduce environmental reservoirs of Legionella in hospitals? A systematic review published pages: e183-e188, ISSN: 0196-6553, DOI: 10.1016/j.ajic.2016.06.018	American Journal of Infection Control 44/11	2020-02-03
2017	Matos, Cristina P.; Alemu, Yemataw A.; Nunes, Patrique; Barroso, Sonia; Alho, Irina; Matos, Antonio P.; Marques, Fernanda; Pessoa, Joao Costa; Correia, Isabel Cytotoxic activity of phenanthroline salicylaldimine zinc(II) complexes published pages: , ISSN: 0949-8257, DOI:	JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY	2020-02-03
2017	Leonardo Ermini, Elena Morganti, Alexander Post, Behzad Yeganeh, Isabella Caniggia, Michael Leadley, Claudia C. Faria, James T. Rutka, Martin Post Imaging mass spectrometry identifies prognostic ganglioside species in rodent intracranial transplants of glioma and medulloblastoma published pages: e0176254, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0176254	PLOS ONE 12/5	2020-02-03
2016	Sofia B. Carvalho, JoÃ£o M. Freire, Mafalda G. Moleirinho, Francisca Monteiro, Diana Gaspar, Miguel A. R. B. Castanho, Manuel J. T. Carrondo, Paula M. Alves, GonÃ§alo J. L. Bernardes, Cristina Peixoto Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles published pages: 2386-2399, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.6b00372	Bioconjugate Chemistry 27/10	2020-02-03
2018	HÃ©lia F. Jeremias, Diana Lousa, Axel Hollmann, Ana C. Coelho, Carla S. Baltazar, JoÃ£o D. Seixas, Ana R. Marques, Nuno C. Santos, Carlos C. RomÃ£o, ClÃ¡udio M. Soares Study of the interactions of bovine serum albumin with a molybdenum(II) carbonyl complex by spectroscopic and molecular simulation methods published pages: e0204624, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0204624	PLOS ONE 13/9	2020-02-03
2017	Ester JimÃ©nez-Moreno, Zijian Guo, Bruno L. Oliveira, InÃªs S. Albuquerque, Annabel Kitowski, Ana Guerreiro, Omar Boutureira, Tiago Rodrigues, Gonzalo JimÃ©nez-OsÃ©s, GonÃ§alo J. L. Bernardes Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells published pages: 243-247, ISSN: 1433-7851, DOI: 10.1002/anie.201609607	Angewandte Chemie International Edition 56/1	2020-02-03
2017	AntÃ³nio M. Mendes, InÃªs S. Albuquerque, Marta Machado, Joana Pissarra, PatrÃcia Meireles, Miguel PrudÃªncio Inhibition of Plasmodium liver infection by ivermectin published pages: AAC.02005-16, ISSN: 0066-4804, DOI: 10.1128/aac.02005-16	Antimicrobial Agents and Chemotherapy	2020-02-03
2018	Clara PÃ©rez-Peinado, Susana Almeida Dias, Marco M. Domingues, AurÃ©lie H. Benfield, JoÃ£o Miguel Freire, Gandhi RÃ¡dis-Baptista, Diana Gaspar, Miguel A. R. B. Castanho, David J. Craik, SÃ³nia Troeira Henriques, Ana SalomÃ© Veiga, David Andreu Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15â€“34), antimicrobial peptides from rattlesnake venom published pages: 1536-1549, ISSN: 0021-9258, DOI: 10.1074/jbc.ra117.000125	Journal of Biological Chemistry 293/5	2020-02-03
2018	Itaru Hamachi, GonÃ§alo J. L. Bernardes Protein engineering through chemical, genetic and computational manipulation published pages: 8977-8979, ISSN: 0306-0012, DOI: 10.1039/c8cs90125b	Chemical Society Reviews 47/24	2020-02-03
2017	Carina Peres, Ana I. Matos, JoÃ£o Conniot, Vanessa Sainz, Eva ZupanÄiÄ, Joana M. Silva, LuÃs GraÃ§a, RogÃ©rio SÃ¡ Gaspar, VÃ©ronique PrÃ©at, Helena F. Florindo Poly(lactic acid)-based particulate systems are promising tools for immune modulation published pages: 41-57, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.11.012	Acta Biomaterialia 48	2020-02-03
2016	Raquel Santos, Diana Gomes, Hermes Macedo, Diogo Barros, Catarina TibÃ©rio, Ana SalomÃ© Veiga, LuÃs Tavares, Miguel Castanho, Manuela Oliveira Guar gum as a new antimicrobial peptide delivery system against diabetic foot ulcers Staphylococcus aureus isolates published pages: 1092-1099, ISSN: 0022-2615, DOI: 10.1099/jmm.0.000329	Journal of Medical Microbiology 65/10	2020-02-03
2016	E.S. BjÃ¶rnsdÃ³ttir, E.R. Martins, H. ErlendsdÃ³ttir, G. Haraldsson, J. Melo-Cristino, K.G. Kristinsson, M. Ramirez Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975â€“2014 published pages: 379.e9-379.e16, ISSN: 1198-743X, DOI: 10.1016/j.cmi.2015.11.020	Clinical Microbiology and Infection 22/4	2020-02-03
2017	Helena Luna Pais, Irina Alho, InÃªs Vendrell, AndrÃ© Mansinho, LuÃs Costa Radionuclides in oncology clinical practice â€“ review of the literature published pages: 14475-14487, ISSN: 1477-9226, DOI: 10.1039/c7dt01929g	Dalton Transactions 46/42	2020-02-03
2016	Sofia Santos Costa, ClÃ¡udia Palma, Kristina Kadlec, Andrea T. Fessler, Miguel Viveiros, JosÃ© Melo-Cristino, Stefan Schwarz, Isabel Couto Plasmid-Borne Antimicrobial Resistance of Staphylococcus aureus Isolated in a Hospital in Lisbon, Portugal published pages: 617-626, ISSN: 1076-6294, DOI: 10.1089/mdr.2015.0352	Microbial Drug Resistance 22/8	2020-02-03
2018	Lisa J. Alcock, Kyle D. Farrell, Mawey T. Akol, Gregory H. Jones, Matthew M. Tierney, Holger B. Kramer, Tara L. Pukala, GonÃ§alo J.L. Bernardes, Michael V. Perkins, Justin M. Chalker Norbornene probes for the study of cysteine oxidation published pages: 1220-1228, ISSN: 0040-4020, DOI: 10.1016/j.tet.2017.11.011	Tetrahedron 74/12	2020-02-03

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The information about "SIMICA" are provided by the European Opendata Portal: CORDIS opendata.