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HD-Neu-Screen SIGNED

HD-MEA-based Neuronal Assays and Network Analysis for Phenotypic Drug Screenings

Total Cost €

EC-Contrib. €

Partnership

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HD-Neu-Screen project word cloud

Explore the words cloud of the HD-Neu-Screen project. It provides you a very rough idea of what is the project "HD-Neu-Screen" about.

free model electrophysiological phenotypic biosystems cell functional translate readout neuronal neuroxscales electrical industry adg lines commercializes hipsc erc poc ag mxwbio subcellular vitro mea overcome assays drug microelectrode array hd components rely platforms label maxwell labs accurate primary company com networks commercially individual neurons limitations screening http commercialize concurrent performed signals density

Project "HD-Neu-Screen" data sheet

The following table provides information about the project.

Coordinator	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	0 €
EC max contribution	150˙000 € (0%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2019-PoC
Funding Scheme	ERC-POC-LS
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2021-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	coordinator	150˙000.00

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Project objective

In order to overcome the limitations of existing methods for phenotypic drug screening, we propose to develop accurate, label-free, functional neuronal assays for phenotypic/functional drug screening in vitro. These assays will rely on the primary readout of neurons - their electrical signals. We propose to translate and commercialize the assessment of characteristic electrophysiological features of subcellular neuronal components, individual neurons and neuronal networks, all of which can be obtained with high-density microelectrode array technology (HD-MEA), into functional neuronal assays for drug screening. Most of these characteristic features have been developed in the concurrent ERC AdG “neuroXscales”. The model systems for the PoC will include commercially available hiPSC-derived neuronal cell lines. The PoC will be performed in collaboration with the company MaxWell Biosystems AG (http://www.mxwbio.com/), which commercializes multi-well HD-MEA platforms for use in research labs and industry.

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The information about "HD-NEU-SCREEN" are provided by the European Opendata Portal: CORDIS opendata.