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DIANA SIGNED

Organ-on-a-chip Drug screenIng device to tArget braiN diseAse

Total Cost €

EC-Contrib. €

Partnership

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DIANA project word cloud

Explore the words cloud of the DIANA project. It provides you a very rough idea of what is the project "DIANA" about.

billion barrier zone organ politecnico market percentage srl 99 parkinson perform ad specialized solid physiology decreasing chip4d device fast point mainly validation model complexity contract hence 6 alone situation combining stand diseases commercial generation pd quality biological diana weak technological cro cross multifaceted bbb worldwide neuro di commitment alzheimer screening innovative rate patented predict investment patients drug assays chip euros expertise critical discouraging vitro organization feasibility brain 15 pharma industrial scenario pathologies depends cell run drugs blood milano experiencing disease decades basis

Project "DIANA" data sheet

The following table provides information about the project.

Coordinator	POLITECNICO DI MILANO Organization address address: PIAZZA LEONARDO DA VINCI 32 city: MILANO postcode: 20133 website: www.polimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	0 €
EC max contribution	150˙000 € (0%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2019-PoC
Funding Scheme	ERC-POC-LS
Starting year	2020
Duration (year-month-day)	from 2020-05-01 to 2021-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	POLITECNICO DI MILANO POLITECNICO DI MILANO Organization address address: PIAZZA LEONARDO DA VINCI 32 city: MILANO postcode: 20133 website: www.polimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	100˙000.00
2	NEURO-ZONE SRL NEURO-ZONE SRL Organization address address: VIA LUDOVICO ARIOSTO 21 city: BRESSO postcode: 20091 website: www.neuro-zone.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BRESSO)	participant	50˙000.00

Map

Project objective

The commitment to drug development for brain pathologies is experiencing a fast rate decreasing, a critical situation in a worldwide scenario where the number of patients affected by brain pathologies like Alzheimer’s (AD) or Parkinson’s (PD) disease are expected to greatly increase in the next decades. One critical point is that the development of new drugs is a three-phase process that currently requires 10-15 years and investment of 1-3 billion euros against a failure rate of about 99.6% for AD new drugs. The reasons of this discouraging scenario are multifaceted, but an important percentage of failure depends on weak quality of biological target validation assays, mainly due to the presence of the blood-brain barrier and the complexity of brain physiology that make challenging brain disease modelling. Hence, it is particularly crucial to implement an innovative, reliable in vitro cell model able to predict the potential of a new drug to cross the blood-brain barrier and effectively target the brain. DIANA (Organ-on-a-chip Drug screenIng device to tArget braiN disease) project aims to perform the technical and commercial feasibility of the integrated stand-alone BBB-brain model in-vitro, Chip4D Brain, based on patented organ on chip technology, providing the basis for a new generation of innovative devices. DIANA will be run by a consortium between Politecnico di Milano and an industrial partner, Neuro-Zone srl (Contract Research Organization – CRO - specialized in R&D for drug development in brain diseases for pharma) combining a solid technological expertise and an in-depth knowledge of the market.

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The information about "DIANA" are provided by the European Opendata Portal: CORDIS opendata.