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PEPTOX SIGNED

An innovative peptide system for novel drugs targeting microbial Repeats-In-Toxin adhesins

Total Cost €

EC-Contrib. €

Partnership

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PEPTOX project word cloud

Explore the words cloud of the PEPTOX project. It provides you a very rough idea of what is the project "PEPTOX" about.

vaccines play cellular threat resistance despite antimicrobial burden synthesis rtx decades suggesting optimise bind last adhesion erc poc pressing mortality infections infection poses peptox characterization therapeutic protein intestine infect social cured adhesin inefficiency block attach prevalence detach cholera heavy leads frha progress diseases compounds promise discovered treatment newly vitro medical model maintaining professionals successfully humankind similarity blockage removed bacteria human ice prevent adhered mutagenesis rapid centuries binding plagued rate

Project "PEPTOX" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	0 €
EC max contribution	150˙000 € (0%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2019-PoC
Funding Scheme	ERC-POC-LS
Starting year	2020
Duration (year-month-day)	from 2020-06-01 to 2021-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	coordinator	150˙000.00

Map

Project objective

Despite progress in infection treatment in the last decades, the prevalence and mortality of infections still poses a heavy burden over humankind. The development of antimicrobial resistance and the rapid mutagenesis of bacteria that leads to inefficiency of vaccines, play an important role in maintaining infections high level of threat. Even diseases that have plagued us for centuries, such as cholera, still challenge medical professionals and cause a significant social cost. New therapeutic approaches that promise a higher success rate are a pressing need. We recently discovered a high similarity between an ice-binding protein and the RTX adhesin (FrhA) used by the bacteria of cholera to attach to and infect the human intestine. Moreover, we discovered compounds that bind to FrhA and successfully block it, suggesting these could help prevent cholera’s infection. If these can also detach already adhered bacteria, cholera could be effectively removed and cured. In this ERC PoC PEPTOX project, we aim to optimise the synthesis and characterization of the newly discovered compounds and demonstrate blockage of cholera adhesion in an in vitro cellular model.

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The information about "PEPTOX" are provided by the European Opendata Portal: CORDIS opendata.