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GrowthDevStability SIGNED

Characterization of the developmental mechanisms ensuring a robust symmetrical growth in the bilateral model organism Drosophila melanogaster

Total Cost €

EC-Contrib. €

Partnership

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GrowthDevStability project word cloud

Explore the words cloud of the GrowthDevStability project. It provides you a very rough idea of what is the project "GrowthDevStability" about.

normal asses adjustment childhood unprecedented overarching expression model functions animal survivors investigation dilp8 action mechanisms mechanism stability understand symmetrical organs player status developmental pathophysiology time disorders organ phenomenon regulation signal bilateral me cancer organism systemic disturbances activated elusive central signaling framework first adjust melanogaster downstream fine regulating hormone effectors size inquiry

Project "GrowthDevStability" data sheet

The following table provides information about the project.

Coordinator	INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	184˙707 €
EC max contribution	184˙707 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-EF-ST
Starting year	2020
Duration (year-month-day)	from 2020-06-01 to 2022-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT CURIE INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	184˙707.00

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Project objective

The overarching objective of the proposed project is to find how and when organs asses their growth status and which mechanisms are deployed to ensure fine size adjustment during normal animal development. As a model system, I will study the symmetrical growth of D. melanogaster, where the signaling hormone Dilp8 has been described as a central player to ensure developmental stability. However, Dilp8 regulation and mechanism of action remain elusive, providing an unprecedented framework to inquiry about the general phenomenon of growth adjustment. I will study when Dilp8 is required and in which organ it is produced during normal development. Also, I will identify signaling pathways regulating Dilp8 expression and the downstream effectors required for its action. This project will allow me to define for the first time how a systemic signal is activated and functions to adjust symmetrical growth in a bilateral model organism. The new concepts introduced by my investigation may help to better understand the pathophysiology of childhood growth disorders, as well as the growth disturbances observed in cancer survivors.

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The information about "GROWTHDEVSTABILITY" are provided by the European Opendata Portal: CORDIS opendata.