Opendata, web and dolomites
RASATaC SIGNED
Regulating RAS Activity to Target RAS-Driven Cancers
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0RASATaC project word cloud
Explore the words cloud of the RASATaC project. It provides you a very rough idea of what is the project "RASATaC" about.
expressed
successfully
quarter
oncogenes
oncogene
innovative
proteins
cancer
forms
avenues
cytotoxic
mutated
ras
poc
truly
family
explore
first
scaffold
death
accordingly
patients
cog
clinic
prove
despite
commercial
treatment
function
care
erc
isoforms
considering
intensive
mutant
protein
moderate
cancers
made
therapeutic
mutations
strategies
effort
scaffolding
active
found
signalling
class
vivo
completely
standards
genes
more
bind
cell
triggers
drugging
exploits
anti
Project "RASATaC" data sheet
The following table provides information about the project.
| Coordinator |
TURUN YLIOPISTO
Organization address contact info |
| Coordinator Country | Finland [FI] |
| Total cost | 0 € |
| EC max contribution | 150˙000 € (0%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-PoC |
| Funding Scheme | ERC-POC-LS |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-06-01 to 2021-11-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TURUN YLIOPISTO | FI (Turku) | coordinator | 150˙000.00 |
Map
Project objective
More than a quarter of all cancers are driven by mutations in the RAS family of genes. Considering the key role of these oncogenes, and despite intensive effort, no effective anti-RAS strategies have successfully made it to the clinic. In our ERC-CoG project, we found that a class of scaffold proteins, expressed in cancer, bind to active/mutated forms of RAS proteins to moderate RAS signalling. Accordingly, we find that loss of one of the scaffolding protein isoforms in RAS-mutant cancers triggers cytotoxic signalling, leading to cell death. As such, drugging this scaffold protein could not only i) represent a completely innovative approach to target RAS-driven cancers that exploits the oncogene’s function, but also ii) deliver the first truly effective cancer treatment for patients that do not respond to current standards of care. In this ERC-PoC, we aim to prove that therapeutic targeting of the scaffold protein is effective in vivo, and to explore the commercial avenues to exploit this finding.
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The information about "RASATAC" are provided by the European Opendata Portal: CORDIS opendata.
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lastchecktime (2024-07-16 10:25:10) correctly updated