#	Pagina
attuale pagina	/open-h2020/projects/228054/index.html

Opendata, web and dolomites

antiCSC SIGNED

Targeting the cancer stem cell (CSC) metabolism with designed, reactive metal complexes

Total Cost €

EC-Contrib. €

Partnership

Views

antiCSC project word cloud

Explore the words cloud of the antiCSC project. It provides you a very rough idea of what is the project "antiCSC" about.

character g4 agents interesting complexes confirm respiration mitochondrial guanines versions deterring explore antitumoral dna quadruplexes assays found bulky suppress cells leads function apparently selective position accessible anticancer biological action labile preliminary experiments conformation stem designed mitochondria compounds scope reactivity mechanism cancer vivo metal react remarkable

Project "antiCSC" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	0 €
EC max contribution	150˙000 € (0%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2019-PoC
Funding Scheme	ERC-POC-LS
Starting year	2020
Duration (year-month-day)	from 2020-09-01 to 2022-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANTIAGO DE COMPOSTELA)	coordinator	130˙000.00
2	UNIVERSIDAD AUTONOMA DE MADRID UNIVERSIDAD AUTONOMA DE MADRID Organization address address: CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO city: MADRID postcode: 28049 website: http://www.uam.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	20˙000.00

Map

Project objective

Designed, bulky metal complexes with a labile coordination position react with accessible guanines at G4 DNA quadruplexes, promoting changes in their conformation and function. Importantly, we have found that this selective reactivity leads to very interesting biological effects. In particular, some of these compounds are able to suppress the “stem”-like character of cancer stem cells, apparently by deterring their mitochondrial respiration. Preliminary experiments, including in vivo assays, confirm that these biological effects result in remarkable antitumoral activities. This proposal aims to explore the scope of the approach, confirm that the mechanism of action involves mitochondria, design more selective versions and exploit the potential of the compounds as new type of anticancer agents.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ANTICSC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ANTICSC" are provided by the European Opendata Portal: CORDIS opendata.