Explore the words cloud of the DOLORisk project. It provides you a very rough idea of what is the project "DOLORisk" about.
The following table provides information about the project.
Coordinator |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | http://dolorisk.eu |
Total cost | 5˙981˙219 € |
EC max contribution | 5˙981˙219 € (100%) |
Programme |
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease) |
Code Call | H2020-PHC-2014-two-stage |
Funding Scheme | RIA |
Starting year | 2015 |
Duration (year-month-day) | from 2015-07-01 to 2020-03-31 |
Take a look of project's partnership.
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1 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | coordinator | 1˙343˙090.00 |
2 | LUNDS UNIVERSITET | SE (LUND) | participant | 686˙250.00 |
3 | UNIVERSITY OF DUNDEE | UK (DUNDEE) | participant | 586˙880.00 |
4 | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE | FR (PARIS) | participant | 538˙348.00 |
5 | NEUROSCIENCE TECHNOLOGIES SLP | ES (Barcelona) | participant | 466˙588.00 |
6 | IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE | UK (LONDON) | participant | 436˙764.00 |
7 | CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL | DE (KIEL) | participant | 411˙250.00 |
8 | TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY | IL (HAIFA) | participant | 406˙250.00 |
9 | AARHUS UNIVERSITET | DK (AARHUS C) | participant | 403˙576.00 |
10 | UNIVERSITEIT GENT | BE (GENT) | participant | 386˙282.00 |
11 | MENTIS CURA EHF | IS (REYKJAVIK) | participant | 177˙500.00 |
12 | AARHUS UNIVERSITETSHOSPITAL | DK (AARHUS) | participant | 138˙440.00 |
Neuropathic pain (NP) is common (population prevalence of 7-8%) and will present a rising health burden in the future. NP results in significant morbidity, reduces quality of life and has a major deleterious impact on health in aging. The reason why some subjects develop neuropathic pain and others do not following the same injury is not known. The exact nature of risk factors for NP and their interaction are currently poorly understood and will be the focus of this project. We will establish an international consortium of leading researchers in the field of NP (DOLORisk consortium) involving members of established academic European consortia studying pain/genomics and neuropathy as well as the SMEs Neuroscience Technologies and Mentis Cura. The project will be highly translational and the starting point will be the study of patients with NP or at risk of developing NP. Specific objectives will be to: 1) Identify the influence of demographic factors, environmental/societal and clinical factors on the risk of developing and maintenance of NP 2) To apply modern genomics to validate (using a targeted approach) and find novel (using genome wide association) genetic risk factors for NP. 3) Use tissue samples and patient derived cells from Biobanks to validate of molecular pathways contributing to chronic pain in patients. 4) To determine if patient stratification using physiological (sensory profile, endogenous analgesic mechanisms and nerve excitability) and psychological factors can predict NP risk and progression. 5) Development of a risk model/algorithm for (severe) NP, combining measurable genetic and environmental factors.
Our aim is to understand pain pathophysiology in terms of risk factors and protective mechanisms ranging from molecular pathways to societal impacts. The desired impact is to provide a firm platform to improve diagnosis and stratify patients according to risk profile, employ preventive strategies and ultimately develop novel therapeutics.
Generation of a protein interaction network using transcriptional profiling and pain risk associated gene outcommes | Websites, patent fillings, videos etc. | 2020-01-14 16:23:14 |
Submission package clinical study 5 | Documents, reports | 2019-10-08 14:19:27 |
Submission package clinical study 7 | Documents, reports | 2019-10-08 14:19:27 |
All approvals package clinical study 2 | Documents, reports | 2019-04-18 15:52:52 |
Submission package clinical study 4 | Documents, reports | 2019-04-18 15:52:52 |
Submission package clinical study 6 | Documents, reports | 2019-04-18 15:52:52 |
Take a look to the deliverables list in detail: detailed list of DOLORisk deliverables.
year | authors and title | journal | last update |
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2019 |
Weihua Meng, Mark J. Adams, Colin N. A. Palmer, Jingchunzi Shi, Adam Auton, Kathleen A. Ryan, Joanne M. Jordan, Braxton D. Mitchell, Rebecca D. Jackson, Michelle S. Yau, Andrew M. McIntosh, Blair H. Smith Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank published pages: 1-8, ISSN: 2399-3642, DOI: 10.1038/s42003-019-0568-2 |
Communications Biology 2/1 | 2019-10-07 |
2019 |
Elke Veirman, Dimitri M. L. Van Ryckeghem, Annick De Paepe, Olivia J. Kirtley, Geert Crombez Multidimensional screening for predicting pain problems in adults published pages: 1, ISSN: 2471-2531, DOI: 10.1097/pr9.0000000000000775 |
PAIN Reports 4(2019) | 2019-10-07 |
2019 |
Wei Wei, Salih Tuna, Michael J. Keogh, Katherine R. Smith, Timothy J. Aitman, Phil L. Beales, David L. Bennett, Daniel P. Gale, Maria A. K. Bitner-Glindzicz, Graeme C. Black, Paul Brennan, Perry Elliott, Frances A. Flinter, R. Andres Floto, Henry Houlden, Melita Irving, Ania Koziell, Eamonn R. Maher, Hugh S. Markus, Nicholas W. Morrell, William G. Newman, Irene Roberts, John A. Sayer, Kenneth G. C Germline selection shapes human mitochondrial DNA diversity published pages: eaau6520, ISSN: 0036-8075, DOI: 10.1126/science.aau6520 |
Science 364/6442 | 2019-09-04 |
2019 |
Lucy A. McDermott, Greg A. Weir, Andreas C. Themistocleous, Andrew R. Segerdahl, Iulia Blesneac, Georgios Baskozos, Alex J. Clark, Val Millar, Liam J. Peck, Daniel Ebner, Irene Tracey, Jordi Serra, David L. Bennett Defining the Functional Role of NaV1.7 in Human Nociception published pages: 905-919.e8, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.01.047 |
Neuron 101/5 | 2019-09-04 |
2019 |
Georgios Baskozos, John M. Dawes, Jean S. Austin, Ana Antunes-Martins, Lucy McDermott, Alex J. Clark, Teodora Trendafilova, Jon G. Lees, Stephen B. McMahon, Jeffrey S. Mogil, Christine Orengo, David L. Bennett Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury published pages: 463-485, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001416 |
PAIN 160/2 | 2019-09-04 |
2017 |
Eva L. Feldman, Klaus-Armin Nave, Troels S. Jensen, David L.H. Bennett New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain published pages: 1296-1313, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.02.005 |
Neuron 93/6 | 2019-09-04 |
2017 |
Greg A Weir, Steven J Middleton, Alex J Clark, Tarun Daniel, Nikita Khovanov, Stephen B McMahon, David L Bennett Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source published pages: 2570-2585, ISSN: 0006-8950, DOI: 10.1093/brain/awx201 |
Brain 140/10 | 2019-09-04 |
2017 |
Astrid J Terkelsen, Páll Karlsson, Giuseppe Lauria, Roy Freeman, Nanna B Finnerup, Troels S Jensen The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes published pages: 934-944, ISSN: 1474-4422, DOI: 10.1016/s1474-4422(17)30329-0 |
The Lancet Neurology 16/11 | 2019-09-04 |
2018 |
Rikke Heide, Hugh Bostock, Lise Ventzel, Peter Grafe, Joseph Bergmans, Anders Fuglsang-Frederiksen, Nanna B. Finnerup, Hatice Tankisi Axonal excitability changes and acute symptoms of oxaliplatin treatment: In vivo evidence for slowed sodium channel inactivation published pages: 694-706, ISSN: 1388-2457, DOI: 10.1016/j.clinph.2017.11.015 |
Clinical Neurophysiology 129/3 | 2019-09-04 |
2018 |
Mathilde M.V. Pascal, Andreas C. Themistocleous, Ralf Baron, Andreas Binder, Didier Bouhassira, Geert Crombez, Nanna B. Finnerup, Janne Gierthmühlen, Yelena Granovsky, Leif Groop, Harry L. Hebert, Troels S. Jensen, Kristinn Johnsen, Mark I. McCarthy, Weihua Meng, Colin N.A. Palmer, Andrew S.C. Rice, Jordi Serra, Romà Solà , David Yarnitsky, Blair H. Smith, Nadine Attal, David L.H. Bennett DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain published pages: 63, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.14576.1 |
Wellcome Open Research 3 | 2019-05-24 |
2018 |
Chongyang Han, Andreas C Themistocleous, Mark Estacion, Fadia B Dib-Hajj, Iulia Blesneac, Lawrence Macala, Carl Fratter, David L Bennett, Stephen G. Waxman, Sulayman D. Dib-Hajj The novel activity of carbamazepine as an activation modulator extends from NaV1.7 mutations to the NaV1.8-S242T mutant channel from a patient with painful diabetic neuropathy published pages: mol.118.113076, ISSN: 0026-895X, DOI: 10.1124/mol.118.113076 |
Molecular Pharmacology | 2019-05-24 |
2018 |
Andreas C. Themistocleous, Geert Crombez, Georgios Baskozos, David L. Bennett Using stratified medicine to understand, diagnose, and treat neuropathic pain published pages: S31-S42, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001301 |
PAIN 159 | 2019-05-24 |
2018 |
Andrew R Segerdahl, Andreas C Themistocleous, Dean Fido, David L Bennett, Irene Tracey A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy published pages: 357-364, ISSN: 0006-8950, DOI: 10.1093/brain/awx337 |
Brain 141/2 | 2019-05-24 |
2018 |
Weihua Meng, Mark J. Adams, Harry L. Hebert, Ian J. Deary, Andrew M. McIntosh, Blair H. Smith A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N = 223,773) published pages: 180-186, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2018.01.023 |
EBioMedicine 28 | 2019-05-24 |
2018 |
Christine B. Sieberg, Caitlin Taras, Aya Gomaa, Chelsea Nickerson, Cindy Wong, Catherine Ward, Georgios Baskozos, David L.H. Bennett, Juan D. Ramirez, Andreas C. Themistocleous, Andrew S.C. Rice, Pallai R. Shillo, Solomon Tesfaye, Robert R. Edwards, Nick A. Andrews, Charles Berde, Michael Costigan Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients published pages: e651, ISSN: 2471-2531, DOI: 10.1097/PR9.0000000000000651 |
PAIN Reports 3/3 | 2019-05-24 |
2018 |
Natalie R. van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh, N. William Rayner, Moustafa Abdalla, Claes Ladenvall, Daniel Ziemek, Eric Fauman, Neil R. Robertson, Paul M. McKeigue, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Annalisa Perna, Erica Rurali, M. Loredana Marcovecchio, Robert P. Igo, Rany M. Salem, Norberto Perico, Maria Lajer, Annemari Käräjämäki, Minako Imamura, Michiaki Kubo, Atsushi Takahashi, Xueling Sim, Jianjun Liu, Rob M. van Dam, Guozhi Jiang, Claudia H.T. Tam, Andrea O.Y. Luk, Heung Man Lee, Cadmon K.P. Lim, Cheuk Chun Szeto, Wing Yee So, Juliana C.N. Chan, Su Fen Ang, Rajkumar Dorajoo, Ling Wang, Tan Si Hua Clara, Amy-Jayne McKnight, Seamus Duffy, Marcus G. Pezzolesi, Michel Marre, Beata Gyorgy, Samy Hadjadj, Linda T. Hiraki, Tarunveer S. Ahluwalia, Peter Almgren, Christina-Alexandra Schulz, Marju Orho-Melander, Allan Linneberg, Cramer Christensen, Daniel R. Witte, Niels Grarup, Ivan Brandslund, Olle Melander, Andrew D. Paterson, David Tregouet, Alexander P. Maxwell, Su Chi Lim, Ronald C.W. Ma, E Shyong Tai, Shiro Maeda, Valeriya Lyssenko, Tiinamaija Tuomi, Andrzej S. Krolewski, Stephen S. Rich, Joel N. Hirschhorn, Jose C. Florez, David Dunger, Oluf Pedersen, Torben Hansen, Peter Rossing, Giuseppe Remuzzi, Mary Julia Brosnan, Colin N.A. Palmer, Per-Henrik Groop, Helen M. Colhoun, Leif C. Groop, Mark I. McCarthy A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes published pages: 1414-1427, ISSN: 0012-1797, DOI: 10.2337/db17-0914 |
Diabetes 67/7 | 2019-05-24 |
2017 |
Harry L Hébert, Bridget Shepherd, Keith Milburn, Abirami Veluchamy, Weihua Meng, Fiona Carr, Louise A Donnelly, Roger Tavendale, Graham Leese, Helen M Colhoun, Ellie Dow, Andrew D Morris, Alexander S Doney, Chim C Lang, Ewan R Pearson, Blair H Smith, Colin N A Palmer Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) published pages: 380-381j, ISSN: 0300-5771, DOI: 10.1093/ije/dyx140 |
International Journal of Epidemiology 47/2 | 2019-05-28 |
2016 |
Giorgio Cruccu, Nanna B. Finnerup, Troels S. Jensen, Joachim Scholz, Marc Sindou, Peter Svensson, Rolf-Detlef Treede, Joanna M. Zakrzewska, Turo Nurmikko Trigeminal neuralgia published pages: 220-228, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000002840 |
Neurology 87/2 | 2019-05-24 |
2017 |
Ralf Baron, Christoph Maier, Nadine Attal, Andreas Binder, Didier Bouhassira, Giorgio Cruccu, Nanna B. Finnerup, Maija Haanpää, Per Hansson, Philipp Hüllemann, Troels S. Jensen, Rainer Freynhagen, Jeffrey D. Kennedy, Walter Magerl, Tina Mainka, Maren Reimer, Andrew S.C. Rice, Märta Segerdahl, Jordi Serra, Sören Sindrup, Claudia Sommer, Thomas Tölle, Jan Vollert, Rolf-Detlef Treede Peripheral neuropathic pain published pages: 261-272, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000753 |
PAIN 158/2 | 2019-05-24 |
2017 |
Harry L. Hébert, Abirami Veluchamy, Nicola Torrance, Blair H. Smith Risk factors for neuropathic pain in diabetes mellitus published pages: 1, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000785 |
PAIN 158/4 | 2019-05-24 |
2015 |
Oliver van Hecke, Peter R. Kamerman, Nadine Attal, Ralf Baron, Gyda Bjornsdottir, David L.H. Bennett, Michael I. Bennett, Didier Bouhassira, Luda Diatchenko, Roy Freeman, Rainer Freynhagen, Maija Haanpää, Troels S. Jensen, Srinivasa N. Raja, Andrew S.C. Rice, Zeʼev Seltzer, Thorgeir E. Thorgeirsson, David Yarnitsky, Blair H. Smith Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies published pages: 2337-2353, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000335 |
PAIN 156/11 | 2019-05-24 |
2017 |
Jan Vollert, Christoph Maier, Nadine Attal, David L.H. Bennett, Didier Bouhassira, Elena K. Enax-Krumova, Nanna B. Finnerup, Rainer Freynhagen, Janne Gierthmühlen, Maija Haanpää, Per Hansson, Philipp Hüllemann, Troels S. Jensen, Walter Magerl, Juan D. Ramirez, Andrew S.C. Rice, Sigrid Schuh-Hofer, Märta Segerdahl, Jordi Serra, Pallai R. Shillo, Soeren Sindrup, Solomon Tesfaye, Andreas C. Themistocleous, Thomas R. Tölle, Rolf-Detlef Treede, Ralf Baron Stratifying patients with peripheral neuropathic pain based on sensory profiles published pages: 1446-1455, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000935 |
PAIN 158/8 | 2019-05-24 |
2016 |
Donna L. Kennedy, Harriet I. Kemp, Deborah Ridout, David Yarnitsky, Andrew S.C. Rice Reliability of conditioned pain modulation published pages: 2410-2419, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000689 |
PAIN 157/11 | 2019-05-24 |
2016 |
Nanna B. Finnerup, Simon Haroutounian, Peter Kamerman, Ralf Baron, David L.H. Bennett, Didier Bouhassira, Giorgio Cruccu, Roy Freeman, Per Hansson, Turo Nurmikko, Srinivasa N. Raja, Andrew S.C. Rice, Jordi Serra, Blair H. Smith, Rolf-Detlef Treede, Troels S. Jensen Neuropathic pain published pages: 1599-1606, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000492 |
PAIN 157/8 | 2019-05-24 |
2016 |
Andreas C. Themistocleous, Juan D. Ramirez, Pallai R. Shillo, Jonathan G. Lees, Dinesh Selvarajah, Christine Orengo, Solomon Tesfaye, Andrew S.C. Rice, David L.H. Bennett The Pain in Neuropathy Study (PiNS) published pages: 1132-1145, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000491 |
PAIN 157/5 | 2019-05-24 |
2017 |
Luana Colloca, Taylor Ludman, Didier Bouhassira, Ralf Baron, Anthony H. Dickenson, David Yarnitsky, Roy Freeman, Andrea Truini, Nadine Attal, Nanna B. Finnerup, Christopher Eccleston, Eija Kalso, David L. Bennett, Robert H. Dworkin, Srinivasa N. Raja Neuropathic pain published pages: 17002, ISSN: 2056-676X, DOI: 10.1038/nrdp.2017.2 |
Nature Reviews Disease Primers 3 | 2019-05-24 |
2018 |
Abirami Veluchamy, Harry L. Hébert, Weihua Meng, Colin N.A. Palmer, Blair H. Smith Systematic review and meta-analysis of genetic risk factors for neuropathic pain published pages: 825-848, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001164 |
PAIN 159/5 | 2019-05-28 |
2018 |
Iulia Blesneac, Andreas C. Themistocleous, Carl Fratter, Linus J. Conrad, Juan D. Ramirez, James J. Cox, Solomon Tesfaye, Pallai R. Shillo, Andrew S.C. Rice, Stephen J. Tucker, David L.H. Bennett Rare Nav1.7 variants associated with painful diabetic peripheral neuropathy published pages: 1, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001116 |
PAIN | 2019-05-28 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DOLORISK" project.
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Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
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The information about "DOLORISK" are provided by the European Opendata Portal: CORDIS opendata.