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DiaChemo SIGNED

Point-of-care microfluidic device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

DiaChemo project word cloud

Explore the words cloud of the DiaChemo project. It provides you a very rough idea of what is the project "DiaChemo" about.

benefits 60 liquid health body hence minimal point outcome drug therapeutic monitoring extraction laboratories intensive detection device chemotherapy decision nowadays depends selective standard small followed ms hospitals time nanoparticle optofluidics electrophoresis chemotherapeutic chip microfluidic patients incorporated care labour spectrometry fluid capillary lab crystal chromatography mass performed drugs quantification clinical lc samples administered

Project "DiaChemo" data sheet

The following table provides information about the project.

Coordinator	ENTE OSPEDALIERO SAVERIO DE BELLIS IRCCS Organization address address: VIA TURI 27 city: CASTELLANA GROTTE BA postcode: 70013 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.diachemo.eu
Total cost	5˙240˙708 €
EC max contribution	4˙654˙333 € (89%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ENTE OSPEDALIERO SAVERIO DE BELLIS IRCCS ENTE OSPEDALIERO SAVERIO DE BELLIS IRCCS Organization address address: VIA TURI 27 city: CASTELLANA GROTTE BA postcode: 70013 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CASTELLANA GROTTE BA)	coordinator	293˙636.00
2	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	984˙208.00
3	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	849˙400.00
4	VERMES MICRODISPENSING GMBH VERMES MICRODISPENSING GMBH Organization address address: PALNKAMER STRASSE 18 city: OTTERFING postcode: 83624 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (OTTERFING)	participant	767˙250.00
5	CENTRO DI RIFERIMENTO ONCOLOGICO DI AVIANO CENTRO DI RIFERIMENTO ONCOLOGICO DI AVIANO Organization address address: VIA FRANCO GALLINI 2 city: AVIANO PN postcode: 33081 website: www.cro.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (AVIANO PN)	participant	716˙375.00
6	LIONIX INTERNATIONAL BV LIONIX INTERNATIONAL BV Organization address address: HENGELOSESTRAAT 500 city: ENSCHEDE postcode: 7521 AN website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ENSCHEDE)	participant	587˙000.00
7	PROVENION GMBH PROVENION GMBH Organization address address: Georg-Wimmer-Ring 25 city: Zorneding postcode: 85604 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Zorneding)	participant	186˙249.00
8	EUROPEAN RESEARCH SERVICES GMBH EUROPEAN RESEARCH SERVICES GMBH Organization address address: ROENTGENSTRASSE 19 city: MUENSTER postcode: 48149 website: www.european-research-services.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	137˙600.00
9	"INSTITUTO TUMORI ""GIOVANNI PAOLO II""" "INSTITUTO TUMORI ""GIOVANNI PAOLO II""" Organization address address: VIA ORAZIO FLACCO 65 city: BARI postcode: 70126 website: www.oncologico.bari.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BARI)	participant	129˙712.00
10	FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA Organization address address: VIA GIOVANNI CELORIA 11 city: MILANO postcode: 20133 website: www.istituto-besta.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	2˙900.00
11	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	0.00
12	LIONIX BV LIONIX BV Organization address address: HENGELOSESTRAAT 500 city: ENSCHEDE postcode: 7521 AN website: www.lionixbv.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ENSCHEDE)	participant	0.00

Map

Project objective

The decision-making in chemotherapy nowadays depends on standard methods that are liquid chromatography (LC-MS/MS) followed by mass spectrometry or capillary electrophoresis; both are labour- and cost-intensive and can be performed only in dedicated hospitals and laboratories. This lead to a minimal therapeutic drug monitoring in patients and hence that 30-60% of drugs are administered without clinical benefits.

We propose to develop a point-of-care device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection incorporated in microfluidic lab-on-chip device (optofluidics based) allowing the real-time drug monitoring. This will improve the therapeutic outcome and reduced health care costs.

Deliverables

List of deliverables.
Project Website	Websites, patent fillings, videos etc.	2019-10-14 15:52:06

Take a look to the deliverables list in detail: detailed list of DiaChemo deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Ye Yang, Guillaume Poss, Yini Weng, Runzhang Qi, Hanrui Zheng, Nikolaos Nianias, Euan R. Kay, Stefan Guldin Probing the interaction of nanoparticles with small molecules in real time via quartz crystal microbalance monitoring published pages: 11107-11113, ISSN: 2040-3364, DOI: 10.1039/c9nr03162f	Nanoscale 11/23	2020-04-15
2018	Luis A. Serrano, Maximiliano J. Fornerod, Ye Yang, Simon Gaisford, Francesco Stellacci, Stefan Guldin Phase behaviour and applications of a binary liquid mixture of methanol and a thermotropic liquid crystal published pages: 4615-4620, ISSN: 1744-683X, DOI: 10.1039/c8sm00327k	Soft Matter 14/22	2020-04-15
2018	Ye Yang, Luis A. Serrano, Stefan Guldin A Versatile AuNP Synthetic Platform for Decoupled Control of Size and Surface Composition published pages: 6820-6826, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b00353	Langmuir 34/23	2019-10-14
2018	Niamh Mac Fhionnlaoich Stephen Schrettl Nicholas B. Tito Ye Yang Malavika Nair Luis A. Serrano Kellen Harkness Paulo Jacob Silva Holger Frauenrath Francesco Stellacci Stefan Guldin Reversible microscale assembly of nanoparticles driven by the phase transition of a thermotropic liquid crystal published pages: , ISSN: 0306-0012, DOI:	ChemRXIV	2019-10-14
2018	Bianca Posocco, Mauro Buzzo, Andrea Follegot, Luciana Giodini, Roberto Sorio, Elena Marangon, Giuseppe Toffoli A new high-performance liquid chromatography-tandem mass spectrometry method for the determination of paclitaxel and 6Î±-hydroxy-paclitaxel in human plasma: Development, validation and application in a clinical pharmacokinetic study published pages: e0193500, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0193500	PLOS ONE 13/2	2019-10-14
2018	Niamh Mac Fhionnlaoich, Stuart Ibsen, Luis A. Serrano, Alaric Taylor, Runzhang Qi, Stefan Guldin A Toolkit to Quantify Target Compounds in Thin-Layer-Chromatography Experiments published pages: 2191-2196, ISSN: 0021-9584, DOI: 10.1021/acs.jchemed.8b00144	Journal of Chemical Education 95/12	2019-10-14

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