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FAPIC SIGNED

Fast Assay for Pathogen Identification and Characterisation

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

FAPIC project word cloud

Explore the words cloud of the FAPIC project. It provides you a very rough idea of what is the project "FAPIC" about.

bacterial weeks emergence clinically intensive pathogens few lasting diagnostic detection faster innovative mechanisms snp saliva cultivation direct antibiotic sensitive virulence dna resistance marker medical urine efficient consuming origins bacteria 1000 patient standard labour guarantee phylogenetic genes hours market diagnostics stool diverse single phenotypical death probe cells material gold day blood limit additionally clinical characterisation time patients hundred treatment techniques

Project "FAPIC" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE LYON 1 CLAUDE BERNARD Organization address address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 city: VILLEURBANNE CEDEX postcode: 69622 website: www.univ-Iyon1.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://www.fapic.eu
Total cost	5˙999˙997 €
EC max contribution	5˙999˙997 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE LYON 1 CLAUDE BERNARD UNIVERSITE LYON 1 CLAUDE BERNARD Organization address address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 city: VILLEURBANNE CEDEX postcode: 69622 website: www.univ-Iyon1.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEURBANNE CEDEX)	coordinator	718˙978.00
2	AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH Organization address address: GIEFINGGASSE 4 city: WIEN postcode: 1210 website: http://www.ait.ac.at/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	1˙352˙496.00
3	AXO SCIENCE SAS AXO SCIENCE SAS Organization address address: RUE DU MAIL 34 city: LYON postcode: 69004 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LYON)	participant	1˙041˙875.00
4	MOLZYM GMBH & CO KG MOLZYM GMBH & CO KG Organization address address: KURFURSTENALLEE 23 A 23A city: BREMEN postcode: 28211 website: www.molzym.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BREMEN)	participant	914˙750.00
5	BEE ROBOTICS LTD BEE ROBOTICS LTD Organization address address: Unit 32/33 Cibyn Ind Estate city: Caernarfon postcode: LL55 2BD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Caernarfon)	participant	775˙875.00
6	THE UNIVERSITY OF WARWICK THE UNIVERSITY OF WARWICK Organization address address: Kirby Corner Road - University House city: COVENTRY postcode: CV4 8UW website: www.warwick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (COVENTRY)	participant	540˙654.00
7	UNIVERSITEIT HASSELT UNIVERSITEIT HASSELT Organization address address: MARTELARENLAAN 42 city: HASSELT postcode: 3500 website: www.uhasselt.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (HASSELT)	participant	336˙504.00
8	LYON INGENIERIE PROJETS LYON INGENIERIE PROJETS Organization address address: BD DU 11 NOVEMBRE 1918 43 L ATRIUM city: VILLEURBANNE postcode: 69616 website: www.lyoningenierie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEURBANNE)	participant	146˙750.00
9	SVEUCILISTE U ZAGREBU MEDICINSKI FAKULTET SVEUCILISTE U ZAGREBU MEDICINSKI FAKULTET Organization address address: SALATA 3 city: ZAGREB postcode: 10 000 website: www.mef.unizg.hr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HR (ZAGREB)	participant	91˙250.00
10	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	80˙865.00

Map

Project objective

The emergence of highly diverse resistance mechanisms among pathogens requires their detailed analysis to guarantee an efficient medical treatment. The gold standard in clinical diagnostics is based on the cultivation of bacteria and their phenotypical characterisation. However, these methods are labour-intensive and time-consuming lasting in some cases up to a few weeks. Thus, faster diagnostic techniques are necessary to ensure an immediate and targeted treatment of the patient. DNA-based diagnostics can provide the relevant results within a few hours. The requirements for a clinical DNA-based characterisation method are high; more than 1000 clinically relevant antibiotic resistance genes, a few hundred phylogenetic marker genes and virulence factors have to be targeted (including SNP detection). The limit of detection has to be low because a few 100 bacterial cells in the blood system can lead to the death of the patient. It should be possible to analyse a wide range of clinical sample origins such as stool, blood, urine and saliva using the same test. In addition, the results have to be obtained within a single working day. In our project, we will develop two diagnostic systems that can be with direct sample material from patients. Thus, the time-consuming cultivation of pathogens will be avoided. Additionally, the test will be more sensitive, specific and faster than any other test on the market using an innovative DNA probe concept.

Deliverables

List of deliverables.
Analysis of bacteremia pilot study teport	Documents, reports	2020-04-01 17:13:52
Clinical advice on relevant targets, samples, patient populations	Documents, reports	2020-04-01 17:13:52
Randomized and blinded panels	Other	2020-04-01 17:13:52
Sample collection B	Other	2020-04-01 17:13:52
Project handbook	Documents, reports	2020-04-01 17:13:52

Take a look to the deliverables list in detail: detailed list of FAPIC deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2015	I. Roca, M. Akova, F. Baquero, J. Carlet, M. Cavaleri, S. Coenen, J. Cohen, D. Findlay, I. Gyssens, O.E. Heure, G. Kahlmeter, H. Kruse, R. Laxminarayan, E. LiÃ©bana, L. LÃ³pez-Cerero, A. MacGowan, M. Martins, J. RodrÃguez-BaÃ±o, J.-M. Rolain, C. Segovia, B. Sigauque, E. Tacconelli, E. Wellington, J. Vila The global threat of antimicrobial resistance: science for intervention published pages: 22-29, ISSN: 2052-2975, DOI: 10.1016/j.nmni.2015.02.007	New Microbes and New Infections 6	2020-04-01
2016	Ramya Salimraj, Lihong Zhang, Philip Hinchliffe, Elizabeth M. H. Wellington, JÃ¼rgen Brem, Christopher J. Schofield, William H. Gaze, James Spencer Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-Î²-Lactamase Identified from a Functional Metagenomic Study published pages: 5828-5840, ISSN: 0066-4804, DOI: 10.1128/AAC.00750-16	Antimicrobial Agents and Chemotherapy 60/10	2020-04-01
2015	Gregory C. A. Amos, Chiara Borsetto, Paris Laskaris, Martin Krsek, Andrew E. Berry, Kevin K. Newsham, Leo Calvo-Bado, David A. Pearce, Carlos Vallin, Elizabeth M. H. Wellington Designing and Implementing an Assay for the Detection of Rare and Divergent NRPS and PKS Clones in European, Antarctic and Cuban Soils published pages: e0138327, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0138327	PLOS ONE 10/9	2020-04-01
2018	Michaela Hendling, Stephan Pabinger, Konrad Peters, Noa Wolff, Rick Conzemius, Ivan BariÅ¡iÄ‡ Oli2go: an automated multiplex oligonucleotide design tool published pages: W252-W256, ISSN: 0305-1048, DOI: 10.1093/nar/gky319	Nucleic Acids Research 46/W1	2020-04-01
2015	Hayley C. King, Andrew Murphy, Phillip James, Emma Travis, David Porter, Jason Sawyer, Jennifer Cork, Richard J. Delahay, William Gaze, Orin Courtenay, Elizabeth M. Wellington Performance of a Noninvasive Test for Detecting Mycobacterium bovis Shedding in European Badger (Meles meles) Populations published pages: 2316-2323, ISSN: 0095-1137, DOI: 10.1128/JCM.00762-15	Journal of Clinical Microbiology 53/7	2020-04-01
2016	Branka BedeniÄ‡, Sanda SardeliÄ‡, Josefa Luxner, Zrinka BoÅ¡njak, Dijana Varda-BrkiÄ‡, Amarela LukiÄ‡-GrliÄ‡, Ivana MarekoviÄ‡, Sonja FranÄula-ZaninoviÄ‡, Marija KrilanoviÄ‡, Dorotea Å ijak, Andrea Grisold, Gernot Zarfel Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia published pages: 74-82, ISSN: 1567-1348, DOI: 10.1016/j.meegid.2016.05.011	Infection, Genetics and Evolution 43	2020-04-01
2016	Branka BedeniÄ‡, NataÅ¡a Firis, Vesna ElveÄ‘i-GaÅ¡paroviÄ‡, Marija KrilanoviÄ‡, KreÅ¡imir MatanoviÄ‡, Iva Å timac, Josefa Luxner, Jasmina VraneÅ¡, Tomislav MeÅ¡troviÄ‡, Gernot Zarfel, Andrea Grisold Emergence of multidrug-resistant Proteus mirabilis in aÂ long-term care facility in Croatia published pages: 404-413, ISSN: 0043-5325, DOI: 10.1007/s00508-016-1005-x	Wiener klinische Wochenschrift 128/11-12	2020-04-01

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