Explore the words cloud of the FAPIC project. It provides you a very rough idea of what is the project "FAPIC" about.
The following table provides information about the project.
Coordinator |
UNIVERSITE LYON 1 CLAUDE BERNARD
Organization address contact info |
Coordinator Country | France [FR] |
Project website | http://www.fapic.eu |
Total cost | 5˙999˙997 € |
EC max contribution | 5˙999˙997 € (100%) |
Programme |
1. H2020-EU.3.1.3. (Treating and managing disease) |
Code Call | H2020-PHC-2014-two-stage |
Funding Scheme | RIA |
Starting year | 2015 |
Duration (year-month-day) | from 2015-05-01 to 2020-04-30 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | UNIVERSITE LYON 1 CLAUDE BERNARD | FR (VILLEURBANNE CEDEX) | coordinator | 718˙978.00 |
2 | AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH | AT (WIEN) | participant | 1˙352˙496.00 |
3 | AXO SCIENCE SAS | FR (LYON) | participant | 1˙041˙875.00 |
4 | MOLZYM GMBH & CO KG | DE (BREMEN) | participant | 914˙750.00 |
5 | BEE ROBOTICS LTD | UK (Caernarfon) | participant | 775˙875.00 |
6 | THE UNIVERSITY OF WARWICK | UK (COVENTRY) | participant | 540˙654.00 |
7 | UNIVERSITEIT HASSELT | BE (HASSELT) | participant | 336˙504.00 |
8 | LYON INGENIERIE PROJETS | FR (VILLEURBANNE) | participant | 146˙750.00 |
9 | SVEUCILISTE U ZAGREBU MEDICINSKI FAKULTET | HR (ZAGREB) | participant | 91˙250.00 |
10 | STICHTING KATHOLIEKE UNIVERSITEIT | NL (NIJMEGEN) | participant | 80˙865.00 |
The emergence of highly diverse resistance mechanisms among pathogens requires their detailed analysis to guarantee an efficient medical treatment. The gold standard in clinical diagnostics is based on the cultivation of bacteria and their phenotypical characterisation. However, these methods are labour-intensive and time-consuming lasting in some cases up to a few weeks. Thus, faster diagnostic techniques are necessary to ensure an immediate and targeted treatment of the patient. DNA-based diagnostics can provide the relevant results within a few hours. The requirements for a clinical DNA-based characterisation method are high; more than 1000 clinically relevant antibiotic resistance genes, a few hundred phylogenetic marker genes and virulence factors have to be targeted (including SNP detection). The limit of detection has to be low because a few 100 bacterial cells in the blood system can lead to the death of the patient. It should be possible to analyse a wide range of clinical sample origins such as stool, blood, urine and saliva using the same test. In addition, the results have to be obtained within a single working day. In our project, we will develop two diagnostic systems that can be with direct sample material from patients. Thus, the time-consuming cultivation of pathogens will be avoided. Additionally, the test will be more sensitive, specific and faster than any other test on the market using an innovative DNA probe concept.
Analysis of bacteremia pilot study teport | Documents, reports | 2020-04-01 17:13:52 |
Clinical advice on relevant targets, samples, patient populations | Documents, reports | 2020-04-01 17:13:52 |
Randomized and blinded panels | Other | 2020-04-01 17:13:52 |
Sample collection B | Other | 2020-04-01 17:13:52 |
Project handbook | Documents, reports | 2020-04-01 17:13:52 |
Take a look to the deliverables list in detail: detailed list of FAPIC deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2015 |
I. Roca, M. Akova, F. Baquero, J. Carlet, M. Cavaleri, S. Coenen, J. Cohen, D. Findlay, I. Gyssens, O.E. Heure, G. Kahlmeter, H. Kruse, R. Laxminarayan, E. Liébana, L. López-Cerero, A. MacGowan, M. Martins, J. RodrÃguez-Baño, J.-M. Rolain, C. Segovia, B. Sigauque, E. Tacconelli, E. Wellington, J. Vila The global threat of antimicrobial resistance: science for intervention published pages: 22-29, ISSN: 2052-2975, DOI: 10.1016/j.nmni.2015.02.007 |
New Microbes and New Infections 6 | 2020-04-01 |
2016 |
Ramya Salimraj, Lihong Zhang, Philip Hinchliffe, Elizabeth M. H. Wellington, Jürgen Brem, Christopher J. Schofield, William H. Gaze, James Spencer Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study published pages: 5828-5840, ISSN: 0066-4804, DOI: 10.1128/AAC.00750-16 |
Antimicrobial Agents and Chemotherapy 60/10 | 2020-04-01 |
2015 |
Gregory C. A. Amos, Chiara Borsetto, Paris Laskaris, Martin Krsek, Andrew E. Berry, Kevin K. Newsham, Leo Calvo-Bado, David A. Pearce, Carlos Vallin, Elizabeth M. H. Wellington Designing and Implementing an Assay for the Detection of Rare and Divergent NRPS and PKS Clones in European, Antarctic and Cuban Soils published pages: e0138327, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0138327 |
PLOS ONE 10/9 | 2020-04-01 |
2018 |
Michaela Hendling, Stephan Pabinger, Konrad Peters, Noa Wolff, Rick Conzemius, Ivan Barišić Oli2go: an automated multiplex oligonucleotide design tool published pages: W252-W256, ISSN: 0305-1048, DOI: 10.1093/nar/gky319 |
Nucleic Acids Research 46/W1 | 2020-04-01 |
2015 |
Hayley C. King, Andrew Murphy, Phillip James, Emma Travis, David Porter, Jason Sawyer, Jennifer Cork, Richard J. Delahay, William Gaze, Orin Courtenay, Elizabeth M. Wellington Performance of a Noninvasive Test for Detecting Mycobacterium bovis Shedding in European Badger (Meles meles) Populations published pages: 2316-2323, ISSN: 0095-1137, DOI: 10.1128/JCM.00762-15 |
Journal of Clinical Microbiology 53/7 | 2020-04-01 |
2016 |
Branka Bedenić, Sanda Sardelić, Josefa Luxner, Zrinka BoÅ¡njak, Dijana Varda-Brkić, Amarela Lukić-Grlić, Ivana Mareković, Sonja FranÄula-Zaninović, Marija Krilanović, Dorotea Å ijak, Andrea Grisold, Gernot Zarfel Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia published pages: 74-82, ISSN: 1567-1348, DOI: 10.1016/j.meegid.2016.05.011 |
Infection, Genetics and Evolution 43 | 2020-04-01 |
2016 |
Branka Bedenić, Nataša Firis, Vesna Elveđi-Gašparović, Marija Krilanović, Krešimir Matanović, Iva Štimac, Josefa Luxner, Jasmina Vraneš, Tomislav Meštrović, Gernot Zarfel, Andrea Grisold Emergence of multidrug-resistant Proteus mirabilis in a long-term care facility in Croatia published pages: 404-413, ISSN: 0043-5325, DOI: 10.1007/s00508-016-1005-x |
Wiener klinische Wochenschrift 128/11-12 | 2020-04-01 |
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