Explore the words cloud of the Paragone project. It provides you a very rough idea of what is the project "Paragone" about.
The following table provides information about the project.
Coordinator |
MOREDUN RESEARCH INSTITUTE
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | http://www.paragoneh2020.eu/ |
Total cost | 8˙998˙559 € |
EC max contribution | 8˙998˙559 € (100%) |
Programme |
1. H2020-EU.3.2. (SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy) |
Code Call | H2020-SFS-2014-2 |
Funding Scheme | RIA |
Starting year | 2015 |
Duration (year-month-day) | from 2015-04-01 to 2019-03-31 |
Take a look of project's partnership.
Helminth and ectoparasitic infections of ruminants and poultry have a huge impact on the biological efficiency of these vital food sources. Indiscriminate antiparasitic use has led to drug resistance across the globe. The main alternative to the dwindling supply of antiparasitics is vaccines. Here, in the PARAGONE project, findings from previous EU and other-funded projects on parasite vaccine development will be exploited to take a number of promising prototypes towards commercialisation. Partners from the Europe, China, Uruguay, SMEs and pharma, will directly move forward prototypes against the ruminant helminths Fasciola hepatica, Cooperia spp., Ostertagia ostertagi, Teladorsagia circumcincta and Haemonchus contortus and, the ectoparasitic mites, Psoroptes ovis (ruminants) and Dermanyssus gallinae (poultry). They will utilise novel adjuvants or delivery systems to maximise efficacy of some of the prototypes. Moreover, immunology studies will focus on pathogens that have previously proved problematic, often because they release immunosuppressive molecules that must be overcome for vaccines to work or because recombinant vaccines have failed to elicit protection observed with native prototypes. State-of-the-art technologies will be used to interrogate host/parasite interactions to define key signatures of protection that can be used to inform delivery systems that will enhance immunity, while other studies will define polymorphism in current vaccine candidates to ensure derived prototypes will be fit-for-purpose across geographic scales. Fundamental, is engagement of the scientists with pharma and other stakeholders (farmers, veterinarians, regulators) via many dissemination activities that will be used to obtain feedback on how the vaccines can be best deployed in the field. The output will be at least two prototypes to the point of uptake by pharma, government or philanthropic agencies, and a clear pathway to commercialisation for all prototypes studied.
Stakeholder Meeting III: Stakeholders\' Input to Prototype Development | Documents, reports | 2020-04-06 08:25:54 |
Immunological Tools Workshop | Documents, reports | 2020-04-06 08:25:54 |
F. hepatica phenotypes | Documents, reports | 2020-04-06 08:25:54 |
PARAGONE website established | Websites, patent fillings, videos etc. | 2020-04-06 08:25:54 |
Take a look to the deliverables list in detail: detailed list of Paragone deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Jorge F. González, Julia N. Hernández, Cynthia MachÃn, Tara Pérez-Hernández, Harry W. Wright, Yolanda Corripio-Miyar, Daniel R. G. Price, Jacqueline B. Matthews, Tom N. McNeilly, Alasdair J. Nisbet Impacts of breed type and vaccination on Teladorsagia circumcincta infection in native sheep in Gran Canaria published pages: 1-7, ISSN: 1297-9716, DOI: 10.1186/s13567-019-0646-y |
Veterinary Research 50/1 | 2020-04-06 |
2018 |
Maria Fernanda Dominguez, Javier González-Miguel, Carlos Carmona, John P. Dalton, Krystyna Cwiklinski, José Tort, Mar Siles-Lucas Low allelic diversity in vaccine candidates genes from different locations sustain hope for Fasciola hepatica immunization published pages: 46-52, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2018.06.011 |
Veterinary Parasitology 258 | 2020-04-06 |
2018 |
Krystyna Cwiklinski, John P. Dalton Advances in Fasciola hepatica research using ‘omics’ technologies published pages: 321-331, ISSN: 0020-7519, DOI: 10.1016/j.ijpara.2017.12.001 |
International Journal for Parasitology 48/5 | 2020-04-06 |
2017 |
Yan Fu, John A. Browne, Kate Killick, Grace Mulcahy Network Analysis of the Systemic Response to Fasciola hepatica Infection in Sheep Reveals Changes in Fibrosis, Apoptosis, Toll-Like Receptors 3/4, and B Cell Function published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00485 |
Frontiers in Immunology 8 | 2020-04-06 |
2016 |
Alessandra Ravidà , Allison M. Aldridge, Nicole N. Driessen, Ferry A. H. Heus, Cornelis H. Hokke, Sandra M. O’Neill Fasciola hepatica Surface Coat Glycoproteins Contain Mannosylated and Phosphorylated N-glycans and Exhibit Immune Modulatory Properties Independent of the Mannose Receptor published pages: e0004601, ISSN: 1935-2735, DOI: 10.1371/journal.pntd.0004601 |
PLOS Neglected Tropical Diseases 10/4 | 2020-04-06 |
2018 |
Akane Tanaka, Venkata Sita Rama Raju Allam, Jennifer Simpson, Natalia Tiberti, Jenna Shiels, Joyce To, Maria Lund, Valery Combes, Sinead Weldon, Cliff Taggart, John P. Dalton, Simon Phipps, Maria B. Sukkar, Sheila Donnelly The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity published pages: , ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.01.050 |
Journal of Allergy and Clinical Immunology | 2020-04-06 |
2016 |
Yan Fu, Andreas L. Chryssafidis, John A. Browne, Jack O\'Sullivan, Paul A. McGettigan, Grace Mulcahy Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection published pages: e0005015, ISSN: 1935-2735, DOI: 10.1371/journal.pntd.0005015 |
PLOS Neglected Tropical Diseases 10/9 | 2020-04-06 |
2016 |
David Smith, Irina G. Tikhonova, Heather L. Jewhurst, Orla C. Drysdale, Jan Dvořák, Mark W. Robinson, Krystyna Cwiklinski, John P. Dalton Unexpected Activity of a Novel Kunitz-type Inhibitor published pages: 19220-19234, ISSN: 0021-9258, DOI: 10.1074/jbc.M116.724344 |
Journal of Biological Chemistry 291/37 | 2020-04-06 |
2019 |
I. L. Pacheco, N. Abril, R. Zafra, N. Morales-Prieto, V. Molina Hernández, M. T. Ruiz, R. Perez-Caballero, A. MartÃnez-Moreno, J. Pérez Identification of reference genes for real-time PCR cytokine gene expression studies in sheep experimentally infected with Fasciola hepatica published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37672-7 |
Scientific Reports 9/1 | 2020-04-06 |
2015 |
Krystyna Cwiklinski, Eduardo de la Torre-Escudero, Maria Trelis, Dolores Bernal, Philippe J. Dufresne, Gerard P. Brennan, Sandra O\'Neill, Jose Tort, Steve Paterson, Antonio Marcilla, John P. Dalton, Mark W. Robinson The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica : Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis published pages: 3258-3273, ISSN: 1535-9476, DOI: 10.1074/mcp.M115.053934 |
Molecular & Cellular Proteomics 14/12 | 2020-04-06 |
2018 |
Laura Garza-Cuartero, Thomas Geurden, Suman M. Mahan, John M. Hardham, John P. Dalton, Grace Mulcahy Antibody recognition of cathepsin L1-derived peptides in Fasciola hepatica -infected and/or vaccinated cattle and identification of protective linear B-cell epitopes published pages: 958-968, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2018.01.020 |
Vaccine 36/7 | 2020-04-06 |
2016 |
A. Escamilla, R. Zafra, J. Pérez, T.N. McNeilly, I.L. Pacheco, L. Buffoni, F.J. MartÃnez-Moreno, V. Molina-Hernández, A. MartÃnez-Moreno Distribution of Foxp3+ T cells in the liver and hepatic lymph nodes of goats and sheep experimentally infected with Fasciola hepatica published pages: 14-19, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2016.10.020 |
Veterinary Parasitology 230 | 2020-04-06 |
2018 |
Raúl Pérez-Caballero, Leandro Buffoni, F. Javier MartÃnez-Moreno, Rafael Zafra, Verónica Molina-Hernández, José Pérez, Ãlvaro MartÃnez-Moreno Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection published pages: , ISSN: 1756-3305, DOI: 10.1186/s13071-018-3072-5 |
Parasites & Vectors 11/1 | 2020-04-06 |
2016 |
Maria E. Lund, Judith Greer, Aakanksha Dixit, Raquel Alvarado, Padraig McCauley-Winter, Joyce To, Akane Tanaka, Andrew T. Hutchinson, Mark W. Robinson, Ann M. Simpson, Bronwyn A. O’Brien, John P. Dalton, Sheila Donnelly A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis published pages: 37789, ISSN: 2045-2322, DOI: 10.1038/srep37789 |
Scientific Reports 6 | 2020-04-06 |
2018 |
Raúl Pérez-Caballero, F. Javier MartÃnez-Moreno, Rafael Zafra, Verónica Molina-Hernández, Isabel L. Pacheco, M. Teresa Ruiz-Campillo, Alejandro Escamilla, José Pérez, Ãlvaro MartÃnez-Moreno, Leandro Buffoni Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis published pages: , ISSN: 1756-3305, DOI: 10.1186/s13071-018-3250-5 |
Parasites & Vectors 11/1 | 2020-04-06 |
2016 |
L. Garza-Cuartero, J. O\'Sullivan, A. Blanco, J. McNair, M. Welsh, R. J. Flynn, D. Williams, P. Diggle, J. Cassidy, G. Mulcahy Fasciola hepatica infection reduces Mycobacterium bovis burden and mycobacterial uptake and suppresses the pro-inflammatory response published pages: 387-402, ISSN: 0141-9838, DOI: 10.1111/pim.12326 |
Parasite Immunology 38/7 | 2020-04-06 |
2016 |
K. Cwiklinski, S. M. O\'Neill, S. Donnelly, J. P. Dalton A prospective view of animal and human Fasciolosis published pages: 558-568, ISSN: 0141-9838, DOI: 10.1111/pim.12343 |
Parasite Immunology 38/9 | 2020-04-06 |
2018 |
Krystyna Cwiklinski, Heather Jewhurst, Paul McVeigh, Tara Barbour, Aaron G. Maule, Jose Tort, Sandra M. O\'Neill, Mark W. Robinson, Sheila Donnelly, John P. Dalton Infection by the Helminth Parasite Fasciola hepatica Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host published pages: 792-809, ISSN: 1535-9476, DOI: 10.1074/mcp.RA117.000445 |
Molecular & Cellular Proteomics 17/4 | 2020-04-06 |
2016 |
Ana González-Hernández, Stefanie Van Coppernolle, Jimmy Borloo, Frederik Van Meulder, Oonagh Paerewijck, Iris Peelaers, Georges Leclercq, Edwin Claerebout, Peter Geldhof Host protective ASP-based vaccine against the parasitic nematode Ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response published pages: 29496, ISSN: 2045-2322, DOI: 10.1038/srep29496 |
Scientific Reports 6 | 2020-04-06 |
2016 |
A. Escamilla, M.J. Bautista, R. Zafra, I.L. Pacheco, M.T. Ruiz, S. MartÃnez-Cruz, A. Méndez, A. MartÃnez-Moreno, V. Molina-Hernández, J. Pérez Fasciola hepatica induces eosinophil apoptosis in the migratory and biliary stages of infection in sheep published pages: 84-88, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2015.12.013 |
Veterinary Parasitology 216 | 2020-04-06 |
2018 |
Ana González-Hernández, Jimmy Borloo, Iris Peelaers, Stijn Casaert, Georges Leclercq, Edwin Claerebout, Peter Geldhof Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora published pages: 41-49, ISSN: 0020-7519, DOI: 10.1016/j.ijpara.2017.07.002 |
International Journal for Parasitology 48/1 | 2020-04-06 |
2016 |
James Pritchard, Tatiana Küster, David George, Olivier Sparagano, Fiona Tomley Impeding movement of the poultry red mite, Dermanyssus gallinae published pages: 104-107, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2016.06.006 |
Veterinary Parasitology 225 | 2020-04-06 |
2016 |
R. Alvarado, J. To, M. E. Lund, A. Pinar, A. Mansell, M. W. Robinson, B. A. OBrien, J. P. Dalton, S. Donnelly The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages published pages: 1 - 11, ISSN: 0892-6638, DOI: 10.1096/fj.201500093R |
The FASEB Journal 28/09/2016 | 2020-04-06 |
2017 |
I.L. Pacheco, N. Abril, N. Morales-Prieto, M.J. Bautista, R. Zafra, A. Escamilla, M.T. Ruiz, A. MartÃnez-Moreno, J. Pérez Th1/Th2 balance in the liver and hepatic lymph nodes of vaccinated and unvaccinated sheep during acute stages of infection with Fasciola hepatica published pages: 61-65, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2017.03.022 |
Veterinary Parasitology 238 | 2020-04-06 |
2017 |
A. Escamilla, R. Pérez-Caballero, R. Zafra, M.J. Bautista, I.L. Pacheco, M.T. Ruiz, M.S. MartÃnez-Cruz, A. MartÃnez-Moreno, V. Molina-Hernández, J. Pérez Apoptosis of peritoneal leucocytes during early stages of Fasciola hepatica infections in sheep published pages: 49-53, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2017.03.015 |
Veterinary Parasitology 238 | 2020-04-06 |
2016 |
Alessandra Ravidà , Krystyna Cwiklinski, Allison M. Aldridge, Paul Clarke, Roisin Thompson, Jared Q. Gerlach, Michelle Kilcoyne, Cornelis H. Hokke, John P. Dalton, Sandra M. O\'Neill Fasciola hepatica Surface Tegument: Glycoproteins at the Interface of Parasite and Host published pages: 3139-3153, ISSN: 1535-9476, DOI: 10.1074/mcp.M116.059774 |
Molecular & Cellular Proteomics 15/10 | 2020-04-06 |
2016 |
C. Carmona, J.F. Tort Fasciolosis in South America: epidemiology and control challenges published pages: 1-11, ISSN: 0022-149X, DOI: 10.1017/S0022149X16000560 |
Journal of Helminthology | 2020-04-06 |
2016 |
Andres Garcia-Campos, Alessandra Ravidà , D. Linh Nguyen, Krystyna Cwiklinski, John P. Dalton, Cornelis H. Hokke, Sandra O’Neill, Grace Mulcahy Tegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycans published pages: e0004688, ISSN: 1935-2735, DOI: 10.1371/journal.pntd.0004688 |
PLOS Neglected Tropical Diseases 10/5 | 2020-04-06 |
2019 |
Alasdair J. Nisbet, Tom N. McNeilly, Daniel R.G. Price, E. Margaret Oliver, Yvonne Bartley, Mairi Mitchell, Javier Palarea-Albaladejo, Jacqueline B. Matthews The rational simplification of a recombinant cocktail vaccine to control the parasitic nematode Teladorsagia circumcincta published pages: 257-265, ISSN: 0020-7519, DOI: 10.1016/j.ijpara.2018.10.006 |
International Journal for Parasitology 49/3-4 | 2020-04-06 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PARAGONE" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "PARAGONE" are provided by the European Opendata Portal: CORDIS opendata.
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