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STEM-BCPC SIGNED

Signal Transduction and Epigenetic Mechanisms of Breast Cell Plasticity and Cancer

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

STEM-BCPC project word cloud

Explore the words cloud of the STEM-BCPC project. It provides you a very rough idea of what is the project "STEM-BCPC" about.

identification million molecular anti breast disease metastasis resistant cascade shp2 fitness models cells crosstalk hypothesize interdisciplinary patients impinges therapies pi3k decrease lives mechanisms alterations outcome fate self metastases options annually treatment genetic neoplastic underpinning technologies underlying driving tumor urgently validate lost cell metastatic epigenetic erk normal diagnosed regulators cancer generate signalling therapy thread prognosis unfortunately worldwide pathophysiologically multipronged drivers clinically 500 interfering programs heterogeneity hyperactivation renewal drug initial interfere interplay plasticity mammary connecting mechanistic clinical uses hurdles efficacy women fatal 1 initiating ultimately surgery unclear

Project "STEM-BCPC" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT BASEL Organization address address: PETERSPLATZ 1 city: BASEL postcode: 4051 website: www.unibas.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Project website	https://bentireslab.org/ourresearch/
Total cost	2˙499˙250 €
EC max contribution	2˙499˙250 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-AdG
Funding Scheme	ERC-ADG
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT BASEL UNIVERSITAT BASEL Organization address address: PETERSPLATZ 1 city: BASEL postcode: 4051 website: www.unibas.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	coordinator	2˙499˙250.00
2	FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION Organization address address: MAULBEERSTRASSE 66 city: BASEL postcode: 4058 website: www.fmi.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00

Map

Project objective

Breast cancer is diagnosed in ~1.4 million women worldwide and ~500,000 lives are lost to the disease annually. Patients may do well after surgery and initial treatment, but drug resistant and fatal metastases often develop. Improved treatment options are urgently needed. The connecting thread of this project is the identification of epigenetic drivers of breast cell fate, tumor heterogeneity and metastasis.

Tumor heterogeneity impinges on prognosis, response to therapy, and metastasis and is one of the most important and clinically relevant areas of cancer research. Tumor heterogeneity results from genetic and epigenetic alterations that enhance the plasticity and fitness of cancer cells in the face of hurdles like the metastatic cascade and anti-cancer therapies. Unfortunately, the driving molecular mechanisms remain unclear, particularly the potential interplay between signalling pathways and epigenetic programs.

This interdisciplinary project uses pathophysiologically relevant models and state-of-the-art technologies to identify molecular mechanisms underlying crosstalk between key signalling pathways and epigenetic programs in the normal and neoplastic breast. We hypothesize that interfering with these programs will decrease tumor heterogeneity.

We will address the effects of: - SHP2/ERK signalling on the epigenetic programs of tumor-initiating cells (Aim 1) - PI3K pathway hyperactivation on the epigenetic programs underpinning cell plasticity (Aim 2) - Epigenetic regulators on normal mammary cell self-renewal and on metastasis (Aim 3)

By investigating the integrated effects of key signalling pathways and epigenetic programs in normal and neoplastic breast, this multipronged project will identify and validate mechanisms of cell plasticity. The derived mechanistic understanding will generate means to interfere with tumor heterogeneity and thus improve the efficacy of anti-cancer therapies and ultimately the clinical outcome for patients with breast cancer.

Publications

List of publications.
year	authors and title	journal	last update
2017	Adrian Britschgi, Stephan Duss, Sungeun Kim, Joana Pinto Couto, Heike Brinkhaus, Shany Koren, Duvini De Silva, Kirsten D. Mertz, Daniela Kaup, Zsuzsanna Varga, Hans Voshol, Alexandra Vissieres, Cedric Leroy, Tim Roloff, Michael B. Stadler, Christina H. Scheel, Loren J. Miraglia, Anthony P. Orth, Ghislain M. C. Bonamy, Venkateshwar A. Reddy, Mohamed Bentires-Alj The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERÎ± published pages: 541-545, ISSN: 0028-0836, DOI: 10.1038/nature20829	Nature 541/7638	2019-09-02
2019	Milan M. S. ObradoviÄ‡, Baptiste Hamelin, Nenad Manevski, Joana Pinto Couto, Atul Sethi, Marie-May Coissieux, Simone MÃ¼nst, Ryoko Okamoto, Hubertus Kohler, Alexander Schmidt, Mohamed Bentires-Alj Glucocorticoids promote breast cancer metastasis published pages: 540-544, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1019-4	Nature 567/7749	2019-09-05
2017	Shany Koren, Mohamed Bentires-Alj Tackling Resistance to PI3K Inhibition by Targeting the Epigenome published pages: 616-618, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2017.04.010	Cancer Cell 31/5	2019-09-05
2017	Kimberly Roche, F. Alex Feltus, Jang Pyo Park, Marie-May Coissieux, Chenyan Chang, Vera B. S. Chan, Mohamed Bentires-Alj, Brian W. Booth Cancer cell redirection biomarker discovery using a mutual information approach published pages: e0179265, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0179265	PLOS ONE 12/6	2019-09-05

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The information about "STEM-BCPC" are provided by the European Opendata Portal: CORDIS opendata.