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MetaRNA

RNA-based technologies for single-cell metabolite analysis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MetaRNA project word cloud

Explore the words cloud of the MetaRNA project. It provides you a very rough idea of what is the project "MetaRNA" about.

cells separated six metarna therapeutics analytical living educates skills organisms interface academia attendance consequently specialists network heterogeneity worldwide platform forces disease programs rna exchange phenotypically trained specialized experts until exists tools sensors complementary relevance esrs instance missing metabolic framework combined groups mobility biotechnological researcher industry eight create limitation workshops synergy etn metabolism private join probe 15 single knowhow exploited training cell severe foundation diagnostics courses stage lack conferences customized overcome population

Project "MetaRNA" data sheet

The following table provides information about the project.

Coordinator	RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.metarna.eu
Total cost	3˙995˙643 €
EC max contribution	3˙995˙643 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	coordinator	510˙748.00
2	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	participant	580˙163.00
3	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	525˙751.00
4	RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN Organization address address: REGINA PACIS WEG 3 city: BONN postcode: 53113 website: www.uni-bonn.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	498˙432.00
5	TECHNISCHE UNIVERSITAT DARMSTADT TECHNISCHE UNIVERSITAT DARMSTADT Organization address address: KAROLINENPLATZ 5 city: DARMSTADT postcode: 64289 website: www.tu-darmstadt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DARMSTADT)	participant	498˙432.00
6	BIOSYNTIA APS BIOSYNTIA APS Organization address address: KOGLE ALLE 6 city: HORSHOLM postcode: 2970 website: www.biosyntia.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HORSHOLM)	participant	290˙081.00
7	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	290˙081.00
8	THE UNIVERSITY OF WARWICK THE UNIVERSITY OF WARWICK Organization address address: Kirby Corner Road - University House city: COVENTRY postcode: CV4 8UW website: www.warwick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (COVENTRY)	participant	273˙287.00
9	DSM FOOD SPECIALTIES BV DSM FOOD SPECIALTIES BV Organization address address: ALEXANDER FLEMINGLAAN 1 city: DELFT postcode: 2613 AX website: www.dsmfoodspecialties.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	participant	255˙374.00
10	THE FRANCIS CRICK INSTITUTE LIMITED THE FRANCIS CRICK INSTITUTE LIMITED Organization address address: 1 MIDLAND ROAD city: LONDON postcode: NW1 1AT website: www.crick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	250˙513.00
11	MEDICAL RESEARCH COUNCIL MEDICAL RESEARCH COUNCIL Organization address address: NORTH STAR AVENUE POLARIS HOUSE 2 FLOOR DAVID PHILLIPS BUILDING city: SWINDON postcode: SN2 1FL website: www.mrc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	22˙773.00
12	APTAIT GMBH APTAIT GMBH Organization address address: LEONHARDISTRASSE 2E city: DIESSEN postcode: 86911 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DIESSEN)	partner	0.00
13	ASSOCIATION POUR LE DEVELOPPEMENT DE L'ENSEIGNEMENT ET DES RECHERCHES AUPRES DES UNIVERSITES, DES CENTRES DE RECHERCHE ET DES ENTREPRISES D'AQUITAINE ASSOCIATION POUR LE DEVELOPPEMENT DE L'ENSEIGNEMENT ET DES RECHERCHES AUPRES DES UNIVERSITES, DES CENTRES DE RECHERCHE ET DES ENTREPRISES D'AQUITAINE Organization address address: AVENUE DU DOCTEUR ALBERT SCHWEITZER - CENTRE CONDORCET 162 city: PESSAC postcode: 33608 website: www.adera.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PESSAC)	partner	0.00
14	EVOLVA AG EVOLVA AG Organization address address: DUGGINGERSTRASSE 23 city: REINACH postcode: 4153 website: www.evolva.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (REINACH)	partner	0.00
15	TPP Global Development TPP Global Development Organization address address: Edinburgh BioQuarter city: Edinburgh postcode: EH16 4UX website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Edinburgh)	partner	0.00

Map

Project objective

Metabolism is the foundation of all living organisms. While cells in a population are often phenotypically different, most of our current analytical approaches still probe metabolism only at the population level. Because strong evidence exists that metabolic cell-to-cell heterogeneity has, for instance, disease relevance, researcher from MetaRNA will overcome this severe analytical limitation through exploiting exciting opportunities emerging from the RNA field. Such synergy potential between the metabolism and RNA research fields has until today not been exploited, because they are separated from each other in Europe and worldwide. Through consequently missing research training programs we thus lack experts with combined knowledge in metabolism and RNA. The aim of the MetaRNA proposal is therefore to establish a European Training Network (ETN) that educates specialists for academia and industry - fully trained at the interface of these two fields - in the development and application of RNA-based sensors to investigate metabolism at the single-cell level, to apply these tools for novel biotechnological applications and to provide a framework for their future use in diagnostics and therapeutics. In MetaRNA, eight research groups from the metabolic and RNA fields and six partners from the private sector join forces to create a platform of mobility and training to 15 early-stage researchers (ESRs), by means of customized research projects, exchange of knowhow among researchers and partners, attendance to specialized courses, workshops and conferences, as well as training in complementary skills.

Deliverables

List of deliverables.
Secondary structure of aptamers in vivo	Documents, reports	2020-02-20 11:28:45
Fluxes through the yeast cell cycle quantified	Documents, reports	2020-02-20 11:28:46
Methodology to optimize RNA-based sensors	Documents, reports	2020-02-20 11:28:46
Highest producing E.coli strains	Other	2020-02-20 11:28:45
Cellular and in vivo delivery of RNA-based sensor	Documents, reports	2020-02-20 11:28:45
Characterisation of normal liver & liver tumour metabolic heterogeneity	Documents, reports	2020-02-20 11:28:45
Highest producing yeast strains	Other	2020-02-20 11:28:45
Optimized RNA-based sensor	Documents, reports	2020-02-20 11:28:46
Test of application of titratable RNA-based sensor	Other	2020-02-20 11:28:46
Elucidation of population wide production heterogeneity on the single cell level	Documents, reports	2020-02-20 11:28:45
Quantitative MS and IMS	Documents, reports	2020-02-20 11:28:46
Adenoviral vectors	Documents, reports	2020-02-20 11:28:44
First flux-sensor validated	Documents, reports	2020-02-20 11:28:44
In vivo screening system	Demonstrators, pilots, prototypes	2020-02-20 11:28:44
RNA-based metabolite sensor	Documents, reports	2020-02-20 11:28:44
First aptamers identified	Documents, reports	2020-02-20 11:28:44
RNA-based sensor for thiamine or coumarate	Documents, reports	2020-02-20 11:28:44
Novel SELEX method	Documents, reports	2020-02-20 11:28:44
Scientific courses	Other	2020-02-20 11:28:44
First flux-signaling metabolites identified	Documents, reports	2020-02-20 11:28:44
Project website	Websites, patent fillings, videos etc.	2020-02-20 11:28:44
Transferable skills courses	Other	2020-02-20 11:28:45

Take a look to the deliverables list in detail: detailed list of MetaRNA deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Adrien Boussebayle, Florian Groher, Beatrix Suess RNA-based Capture-SELEX for the selection of small molecule-binding aptamers published pages: 10-15, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2019.04.004	Methods 161	2020-02-20
2019	Adrien Boussebayle, Florian Groher, Beatrix Suess RNA-based Capture-SELEX for the selection of small molecule-binding aptamers published pages: 10-15, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2019.04.004	Methods 161	2020-02-20
2018	Vakil Takhaveev, Matthias Heinemann Metabolic heterogeneity in clonal microbial populations published pages: 30-38, ISSN: 1369-5274, DOI: 10.1016/j.mib.2018.02.004	Current Opinion in Microbiology 45	2020-02-20
2018	Louise Fets, Paul C. Driscoll, Fiona Grimm, Aakriti Jain, PatrÃcia M. Nunes, Michalis Gounis, Ginevra Doglioni, George Papageorgiou, Timothy J. Ragan, Sebastien Campos, Mariana Silva dos Santos, James I. MacRae, Nicola Oâ€™Reilly, Alan J. Wright, Cyril H. Benes, Kevin D. Courtney, David House, Dimitrios Anastasiou MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG published pages: 1032-1042, ISSN: 1552-4450, DOI: 10.1038/s41589-018-0136-y	Nature Chemical Biology 14/11	2020-02-20
2019	Adrien Boussebayle, Daniel Torka, Sandra Ollivaud, Johannes Braun, Cristina Bofill-Bosch, Max Dombrowski, Florian Groher, Kay Hamacher, Beatrix Suess Next-level riboswitch developmentâ€”implementation of Capture-SELEX facilitates identification of a new synthetic riboswitch published pages: 4883-4895, ISSN: 0305-1048, DOI: 10.1093/nar/gkz216	Nucleic Acids Research 47/9	2020-02-20
2019	Josi Buerger, Luisa S. Gronenberg, Hans Jasper Genee, Morten O.A. Sommer Wiring cell growth to product formation published pages: 85-92, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2019.02.014	Current Opinion in Biotechnology 59	2020-02-20
2017	Leonie J. Jahn, Christian Munck, Mostafa M. H. Ellabaan, Morten O. A. Sommer Adaptive Laboratory Evolution of Antibiotic Resistance Using Different Selection Regimes Lead to Similar Phenotypes and Genotypes published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.00816	Frontiers in Microbiology 8	2020-02-20
2018	Leonie Johanna Jahn, Andreas Porse, Christian Munck, Daniel Simon, Svetlana Volkova, Morten Otto Alexander Sommer Chromosomal barcoding as a tool for multiplexed phenotypic characterization of laboratory evolved lineages published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25201-5	Scientific Reports 8/1	2020-02-20
2019	Simeon Leupold, Georg Hubmann, Athanasios Litsios, Anne C Meinema, Vakil Takhaveev, Alexandros Papagiannakis, Bastian Niebel, Georges Janssens, David Siegel, Matthias Heinemann Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative lifespan published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.41046	eLife 8	2020-02-20
2019	Sara Masachis, Nicolas J Tourasse, Claire Lays, Marion Faucher, Sandrine Chabas, Isabelle Iost, Fabien Darfeuille A genetic selection reveals functional metastable structures embedded in a toxin-encoding mRNA published pages: , ISSN: , DOI: 10.1101/615682	Bioxriv	2020-02-20
2017	Danny Filer, Maximillian A. Thompson, Vakil Takhaveev, Adam J. Dobson, Ilektra Kotronaki, James W. M. Green, Matthias Heinemann, Jennifer M. A. Tullet, Nazif Alic RNA polymerase III limits longevity downstream of TORC1 published pages: 263-267, ISSN: 0028-0836, DOI: 10.1038/nature25007	Nature 552/7684	2020-02-20
2019	Stefan Breuers, Laura Lledo Bryant, Tjasa Legen, GÃ¼nter Mayer Robotic assisted generation of 2â€²-deoxy-2â€²-fluoro-modifed RNA aptamers â€“ High performance enabling strategies in aptamer selection published pages: 3-9, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2019.05.022	Methods 161	2020-02-20
2016	Dimitrios Anastasiou Tumour microenvironment factors shaping the cancer metabolism landscape published pages: 277-286, ISSN: 0007-0920, DOI: 10.1038/bjc.2016.412	British Journal of Cancer 116/3	2020-02-20
2016	Manish Kushwaha, William Rostain, Satya Prakash, John N. Duncan, Alfonso Jaramillo Using RNA as Molecular Code for Programming Cellular Function published pages: 795-809, ISSN: 2161-5063, DOI: 10.1021/acssynbio.5b00297	ACS Synthetic Biology 5/8	2020-02-20
2017	HÃ©lÃ¨ne Arnion, DursunÂ Nizam Korkut, Sara MasachisÂ Gelo, Sandrine Chabas, JÃ©rÃ©my Reignier, Isabelle Iost, Fabien Darfeuille Mechanistic insights into type I toxin antitoxin systems in Helicobacter pylori: the importance of mRNA folding in controlling toxin expression published pages: gkw1343, ISSN: 0305-1048, DOI: 10.1093/nar/gkw1343	Nucleic Acids Research	2020-02-20

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