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ECMED

The Extracellular Matrix in Epileptogenesis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ECMED project word cloud

Explore the words cloud of the ECMED project. It provides you a very rough idea of what is the project "ECMED" about.

realised industry function benefit epilepsy extracellular diagnosis full visits resistant considerable courses whilst truly biology burden stroke treat critical injury collaborative diagnostic association prevent pertinent autism signalling science ecm 30 training translational neuronal neurodegeneration therapies tools excitability over society brings network worldwide questions laboratory plays neuroscience traumatic proteins workshops expanding protein meetings prognosis members trainees diseases exposed considerably mutations theme experts basic effort treatment pressing expertise industrial ideal inter million academic matrix combination question governing people brain young joint

Project "ECMED" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.ecmed-itn.eu
Total cost	3˙047˙025 €
EC max contribution	3˙047˙025 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	273˙287.00
2	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 website: www.iit.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	participant	516˙122.00
3	DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV Organization address address: SIGMUND FREUD STRASSE 27 city: BONN postcode: 53127 website: www.dzne.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	498˙432.00
4	ITA-SUOMEN YLIOPISTO ITA-SUOMEN YLIOPISTO Organization address address: YLIOPISTONRANTA 1 E city: KUOPIO postcode: 70211 website: www.uef.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (KUOPIO)	participant	269˙145.00
5	UNIVERSITE D'AIX MARSEILLE UNIVERSITE D'AIX MARSEILLE Organization address address: Boulevard Charles Livon 58 city: Marseille postcode: 13284 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Marseille)	participant	262˙875.00
6	AMC MEDICAL RESEARCH BV AMC MEDICAL RESEARCH BV Organization address address: MEIBERGDREEF 9 city: AMSTERDAM ZUIDOOST postcode: 1105AZ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM ZUIDOOST)	participant	255˙374.00
7	UNIVERSITEIT ANTWERPEN UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ANTWERPEN)	participant	250˙560.00
8	LEIBNIZ-INSTITUT FUER NEUROBIOLOGIE LEIBNIZ-INSTITUT FUER NEUROBIOLOGIE Organization address address: BRENNECKESTRASSE 6 city: MAGDEBURG postcode: 39118 website: www.ifn-magdeburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MAGDEBURG)	participant	249˙216.00
9	IPROTEOS SL IPROTEOS SL Organization address address: CALLE BALDIRI REIXAC 10 city: BARCELONA postcode: 8028 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	247˙872.00
10	INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK Organization address address: UL. LUDWIKA PASTEURA 3 city: WARSZAWA postcode: 02 093 website: www.nencki.gov.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (WARSZAWA)	participant	224˙137.00
11	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	0.00

Map

Project objective

Over 50 million people worldwide have epilepsy and 30% are resistant to our present therapies. Epilepsy, therefore, comprises a major burden to society and so there is a pressing need for new approaches to treatment. The brain extracellular matrix (ECM) plays a critical role in governing brain excitability and function. Although research into the role of the ECM in neuronal signalling and network function has advanced considerably in recent years, its full translational potential has yet to be realised. There is growing evidence for a major role of the ECM in epilepsy including the association between ECM protein mutations and epilepsy, changes in the ECM and associated proteins during the development of epilepsy and the strong association between the ECM and brain diseases associated with epilepsy including stroke, traumatic brain injury, neurodegeneration and autism. This proposal brings together considerable expertise from academic and industry partners in the biology of the ECM with experts in epilepsy research. This, therefore, represents a truly collaborative effort to determine not only the role of the ECM in the development of epilepsy but also novel approaches to treat and to prevent epilepsy. The academic partners will focus on specific research questions, whilst the industrial members will provide diagnostic, treatment and advanced research tools. The project has a strong translational theme and the combination of basic and translational science will be of great benefit for the training of young researchers. Trainees will be exposed to courses, workshops, joint research meetings and inter-laboratory visits. The focus of the training programme is on expanding knowledge and the application of such knowledge to address pertinent question relevant to the diagnosis, prognosis and treatment of epilepsy, so providing an ideal insight into translational neuroscience.

Deliverables

List of deliverables.
Advanced training course 4	Other	2019-09-06 08:35:51
New data on the mechanisms of epileptogenesis	Documents, reports	2019-09-06 08:35:51
New data on the mechanisms of epileptogenesis-2	Documents, reports	2019-09-06 08:35:51
Advanced training course 2	Other	2019-09-06 08:35:51
Advanced training course 3	Other	2019-09-06 08:35:51
New approach for seizure analysis	Demonstrators, pilots, prototypes	2019-09-06 08:35:51
ECMED network website and flyer	Websites, patent fillings, videos etc.	2019-09-06 08:35:51
Advanced Training course 1	Other	2019-09-06 08:35:51

Take a look to the deliverables list in detail: detailed list of ECMED deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	John R. Counsell, Rajvinder Karda, Juan Antinao Diaz, Louise Carey, Tatiana Wiktorowicz, Suzanne M.K. Buckley, Shima Ameri, Joanne Ng, Julien Baruteau, Filipa Almeida, Rohan de Silva, Roberto Simone, Eleonora LugarÃ , Gabriele Lignani, Dirk Lindemann, Axel Rethwilm, Ahad A. Rahim, Simon N. Waddington, Steven J. Howe Foamy Virus Vectors Transduce Visceral Organs and Hippocampal Structures following InÂ Vivo Delivery to Neonatal Mice published pages: 626-634, ISSN: 2162-2531, DOI: 10.1016/j.omtn.2018.07.006	Molecular Therapy - Nucleic Acids 12	2019-09-06
2018	John R. Counsell, Rajvinder Karda, Juan Antinao Diaz, Louise Carey, Tatiana Wiktorowicz, Suzanne M.K. Buckley, Shima Ameri, Joanne Ng, Julien Baruteau, Filipa Almeida, Rohan de Silva, Roberto Simone, Eleonora LugarÃ , Gabriele Lignani, Dirk Lindemann, Axel Rethwilm, Ahad A. Rahim, Simon N. Waddington, Steven J. Howe Foamy Virus Vectors Transduce Visceral Organs and Hippocampal Structures following InÂ Vivo Delivery to Neonatal Mice published pages: 626-634, ISSN: 2162-2531, DOI: 10.1016/j.omtn.2018.07.006	Molecular Therapy - Nucleic Acids 12	2019-09-06
2018	Pierluigi Valente, Alessandra Romei, Manuela Fadda, Bruno Sterlini, Davide Lonardoni, Nicola Forte, Floriana Fruscione, Enrico Castroflorio, Caterina Michetti, Giorgia Giansante, Flavia Valtorta, Jin-Wu Tsai, Federico Zara, Thierry Nieus, Anna Corradi, Anna Fassio, Pietro Baldelli, Fabio Benfenati Constitutive Inactivation of the PRRT2 Gene Alters Short-Term Synaptic Plasticity and Promotes Network Hyperexcitability in Hippocampal Neurons published pages: , ISSN: 1047-3211, DOI: 10.1093/cercor/bhy079	Cerebral Cortex	2019-09-06
2017	A. Korotkov, J. D. Mills, J. A. Gorter, E. A. van Vliet, E. Aronica Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-11510-8	Scientific Reports 7/1	2019-09-06
2015	Gianpiero Garau, Paola Magotti, Martin Heine, Svetlana Korotchenko, Patricia Marie-Jeanne Lievens, Vladimir Berezin, Alexander Dityatev Heparin/heparan sulfates bind to and modulate neuronal L-type (Cav1.2) voltage-dependent Ca2+ channels published pages: 156-165, ISSN: 0014-4886, DOI: 10.1016/j.expneurol.2015.08.006	Experimental Neurology 274	2019-09-06
2018	Floriana Fruscione, Pierluigi Valente, Bruno Sterlini, Alessandra Romei, Simona Baldassari, Manuela Fadda, Cosimo Prestigio, Giorgia Giansante, Jacopo Sartorelli, Pia Rossi, Alicia Rubio, Antonio Gambardella, Thierry Nieus, Vania Broccoli, Anna Fassio, Pietro Baldelli, Anna Corradi, Federico Zara, Fabio Benfenati PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity published pages: 1000-1016, ISSN: 0006-8950, DOI: 10.1093/brain/awy051	Brain 141/4	2019-09-06
2016	van Vliet, Erwin A; Potschka, Heidrun; Koepp, Matthias J; Immonen, Riikka; Federico, Paolo; Friedman, Alon; PitkÃ¤nen, Asla; Cole, Andrew J.; Dedeurwaerdere, Stefanie Workshop on neurobiology of epilepsy appraisal: Imaging biomarkers in epilepsy published pages: , ISSN: 1528-1167, DOI: 10.1111/epi.13621	Epilepsia 1	2019-09-06
2017	A. Korotkov, J. D. Mills, J. A. Gorter, E. A. van Vliet, E. Aronica Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-11510-8	Scientific Reports 7/1	2019-09-06

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