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MATRIXASSAY

Novel Cell Migration Assay Based on Microtissue Technology and Tissue-Specific Matrices

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MATRIXASSAY project word cloud

Explore the words cloud of the MATRIXASSAY project. It provides you a very rough idea of what is the project "MATRIXASSAY" about.

align sec direction damage zone relationships sizes cancer scratch closure assay cells crimp co electromechanical employed piezoelectric predictive zones irreproducible prototype structure tendon interval extracellular healing pristine ecm substrate coupled matrix native scratched damages properties accomplishing alters least domains avoiding viscoelastic questions deformation fibril wound influence collagen stopper unusual bonding mm invasion power alignment significantly polar cell diameter seeding types matrices mimics mechanical speed limited tissue anisotropic size migration functional 01 thicknesses critical shapes assays property gap reproducible precisely

Project "MATRIXASSAY" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Organization address address: BELFIELD city: DUBLIN postcode: 4 website: www.ucd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	http://www.ucd.ie/matrixassay/
Total cost	1˙053˙000 €
EC max contribution	931˙500 € (88%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2014
Funding Scheme	MSCA-RISE
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2019-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Organization address address: BELFIELD city: DUBLIN postcode: 4 website: www.ucd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	coordinator	216˙000.00
2	LOUGHBOROUGH UNIVERSITY LOUGHBOROUGH UNIVERSITY Organization address address: ASHBY ROAD city: LOUGHBOROUGH postcode: LE11 3TU website: www.lboro.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LOUGHBOROUGH)	participant	324˙000.00
3	ABERYSTWYTH UNIVERSITY ABERYSTWYTH UNIVERSITY Organization address address: VISUALISATION CENTRE PENGLAIS city: ABERYSTWYTH postcode: SY23 3BF website: http://www.aber.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ABERYSTWYTH)	participant	310˙500.00
4	BLAFAR LIMITED BLAFAR LIMITED Organization address address: 1 CLONFADDA WOOD MOUNT MERRIION AVENUE city: BLACKROCK DUBLIN postcode: A94W1K6 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (BLACKROCK DUBLIN)	participant	40˙500.00
5	MSC.SOFTWARE LTD. MSC.SOFTWARE LTD. Organization address address: msc house/lyon way city: FRIMLEY, CAMBERLEY SURREY postcode: GU16 7ER website: http://www.mscsoftware.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (FRIMLEY, CAMBERLEY SURREY)	participant	27˙000.00
6	ASHLAND SPECIALTIES IRELAND LIMITED ASHLAND SPECIALTIES IRELAND LIMITED Organization address address: SYNERGY CENTRE, LABORATORY A, TECHNOLOGICAL UNIVERSITY DUBLIN (Tu Dublin), TALLAGHT city: Dublin postcode: D24 A386 website: www.vornia.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Dublin)	participant	13˙500.00
7	FIBRALIGN CORPORATION FIBRALIGN CORPORATION Organization address address: 32930 ALVARADO NILES ROAD SUITE 350 city: UNION CITY CA postcode: 94587 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (UNION CITY CA)	partner	0.00
8	GRIFFITH UNIVERSITY GRIFFITH UNIVERSITY Organization address address: KESSELS ROAD NATHAN city: BRISBANE postcode: 4111 website: www.rivers.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (BRISBANE)	partner	0.00
9	INSPHERO AG INSPHERO AG Organization address address: WAGISTRASSE 27 city: SCHLIEREN postcode: 8952 website: www.insphero.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (SCHLIEREN)	partner	0.00
10	THE UNIVERSITY OF TEXAS SYSTEM THE UNIVERSITY OF TEXAS SYSTEM Organization address address: COLORADO STREET 601 city: AUSTIN postcode: 78701 2982 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (AUSTIN)	partner	0.00

Map

Project objective

Cell migration assays are commonly used to study wound healing, cancer cell invasion, and tissue development. Problems associated with the gap closure assays typically employed are that: (i) the stopper or scratch used to make the migration zone damages the extracellular matrix (ECM), (ii) the migration zone size is limited by the size of the stopper, and (iii) the scratched migration zone shapes and sizes are irreproducible. Cell migration is strongly coupled with the structure and mechanical properties of the ECM, and damage to the ECM alters the cell migration path.

The main objective of this project is to develop a prototype novel cell migration assay, which will significantly improve the predictive power of cell-based assays while avoiding problems associated with existing assays, based on seeding cells precisely on pristine extracellular matrix tissue mimics with native-like cell-functionality and reproducible migration zones.

In accomplishing this, we will also address the following questions: • What are the structure-property relationships between collagen I matrices with controlled thicknesses and fibril diameter and alignment, and their mechanical and electromechanical properties? • What are the critical parameters for achieving functional bonding between the substrate and the highly anisotropic viscoelastic collagen I matrices and controlling the overall mechanical properties? • Does the distribution of collagen fibril polar ordering, i.e., piezoelectric domains, influence cell migration? • What parameters control crimp formation in tendon-like collagen I matrices? • What parameters control and explain the unusual viscoelastic properties (e.g., they not depend on the speed of deformation, at least within the interval 0.01 - 1 mm/sec) of tendon-like collagen matrices? • Which cell types, including cancer cells, co-align with collagen fibril alignment or crimp direction?

Deliverables

List of deliverables.
Yearly report on scientific and technical progress 3	Documents, reports	2020-02-06 16:17:12
Yearly report & management of next yearâ€™s outreach activities 3	Documents, reports	2020-02-06 16:17:12
Abstracts of the workshop	Documents, reports	2020-02-06 16:17:11
Yearly report on scientific and technical progress 1	Documents, reports	2020-02-06 16:17:11
Yearly report & management of next yearâ€™s outreach activities 1	Documents, reports	2020-02-06 16:17:11
Yearly report & management of next yearâ€™s outreach activities 2	Documents, reports	2020-02-06 16:17:12
Yearly report on scientific and technical progress 2	Documents, reports	2020-02-06 16:17:12

Take a look to the deliverables list in detail: detailed list of MATRIXASSAY deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Sawsan Almohammed, Maha Alruwaili, Emmanuel G. Reynaud, Gareth Redmond, James H. Rice, Brian J. Rodriguez 3D-Printed Peptide-Hydrogel Nanoparticle Composites for Surface-Enhanced Raman Spectroscopy Sensing published pages: , ISSN: 2574-0970, DOI: 10.1021/acsanm.9b00940	ACS Applied Nano Materials	2020-02-06
2019	Sawsan Almohammed, Fengyuan Zhang, Brian J. Rodriguez, James H. Rice Electric Field-Induced Chemical Surface-Enhanced Raman Spectroscopy Enhancement from Aligned Peptide Nanotubeâ€“Graphene Oxide Templates for Universal Trace Detection of Biomolecules published pages: 1878-1887, ISSN: 1948-7185, DOI: 10.1021/acs.jpclett.9b00436	The Journal of Physical Chemistry Letters 10/8	2020-02-06
2019	Sawsan Almohammed, Brian J. Rodriguez, James H. Rice Nucleobase sensing using highly-sensitive surface-enhanced Raman spectroscopy templates comprising organic semiconductor peptide nanotubes and metal nanoparticles published pages: 100287, ISSN: 2214-1804, DOI: 10.1016/j.sbsr.2019.100287	Sensing and Bio-Sensing Research 24	2020-02-06
2019	Maha Alruwaili, Jose A. Lopez, Kevin McCarthy, Emmanuel G. Reynaud, Brian J. Rodriguez Liquid-phase 3D bioprinting of gelatin alginate hydrogels: influence of printing parameters on hydrogel line width and layer height published pages: , ISSN: 2096-5524, DOI: 10.1007/s42242-019-00043-w	Bio-Design and Manufacturing	2020-02-06
2019	RICCARDO MOLINAROLO EXISTENCE OF SOLUTIONS FOR A SINGULARLYPERTURBED NONLINEAR NON-AUTONOMOUSTRANSMISSION PROBLEM published pages: 1â€“29, ISSN: 1072-6691, DOI:	Electronic Journal of Differential Equations Vol. 2019 (2019), No. 53, pp. 1	2020-02-06
2018	Daniel Peck, Michal Wrobel, Monika Perkowska, Gennady Mishuris Fluid velocity based simulation of hydraulic fracture: a penny shaped modelâ€”part I: the numerical algorithm published pages: 3615-3635, ISSN: 0025-6455, DOI: 10.1007/s11012-018-0899-y	Meccanica 53/15	2020-02-06
2018	Emrah Sozumert, Farukh Farukh, Baris Sabuncuoglu, Emrah Demirci, Memis Acar, Behnam Pourdeyhimi, Vadim V. Silberschmidt Deformation and damage of random fibrous networks published pages: , ISSN: 0020-7683, DOI: 10.1016/j.ijsolstr.2018.12.012	International Journal of Solids and Structures	2020-02-06
2018	Sawsan Almohammed, Fengyuan Zhang, Brian J. Rodriguez, James H. Rice Photo-induced surface-enhanced Raman spectroscopy from a diphenylalanine peptide nanotube-metal nanoparticle template published pages: 3880, ISSN: 2045-2322, DOI: 10.1038/s41598-018-22269-x	Scientific Reports 8/1	2020-02-06
2017	Davies, I. T. Simulating the interaction between a falling super-quadric object and a soap film published pages: , ISSN: , DOI:	1	2020-02-06
2016	Sergei Rogosin, Gennady Mishuris, Anna Koroleva, Anastasiya Vinakurava ANALYSIS OF THE UNILATERAL CONTACT PROBLEM FOR BIPHASIC CARTILAGE LAYERS WITH AN ELLIPTIC CONTACT ZONE AND ACCOUNTING FOR TANGENTIAL DISPLACEMENTS published pages: 585-609, ISSN: 1392-6292, DOI: 10.3846/13926292.2016.1196249	Mathematical Modelling and Analysis 21/5	2020-02-06
2018	F. Zaccagnino, A. Audebert, S. J. Cox Simulation of surfactant transport during the rheological relaxation of two-dimensional dry foams published pages: , ISSN: 2470-0045, DOI: 10.1103/PhysRevE.98.022801	Physical Review E 98/2	2020-02-06
2017	Gennaro Vitucci, Gennady Mishuris Three-dimensional contact of transversely isotropic transversely homogeneous cartilage layers: A closed-form solution published pages: 195-204, ISSN: 0997-7538, DOI: 10.1016/j.euromechsol.2017.04.004	European Journal of Mechanics - A/Solids 65	2020-02-06
2017	Teixeira, Miguel; Arscott, Steve; Cox, Simon; Teixeira, Paulo Ivo Cortez When is a surface foam-phobic? published pages: , ISSN: , DOI:	TEIXEIRA, Miguel [et al] â€“ When is a surface foam-phobic?. In 10th Liquid Matter Conference, Ljubljana Slovenia, 2017. 1	2020-02-06
2018	Liam Collins, Stefan A.L. Weber, Brian J. Rodriguez Applications of KPFM-Based Approaches for Surface Potential and Electrochemical Measurements in Liquid published pages: 391-433, ISSN: , DOI: 10.1007/978-3-319-75687-5_13		2020-02-06
2018	Liam Collins, Jason I Kilpatrick, Sergei V Kalinin, Brian J Rodriguez Towards nanoscale electrical measurements in liquid by advanced KPFM techniques: a review published pages: 86101, ISSN: 0034-4885, DOI: 10.1088/1361-6633/aab560	Reports on Progress in Physics 81/8	2020-02-06
2017	Arwa Bazaid, Sabine M Neumayer, Anna Sorushanova, Jill Guyonnet, Dimitrios Zeugolis, Brian J Rodriguez Non-destructive determination of collagen fibril width in extruded collagen fibres by piezoresponse force microscopy published pages: 55004, ISSN: 2057-1976, DOI: 10.1088/2057-1976/aa85ec	Biomedical Physics & Engineering Express 3/5	2020-02-06
2019	Sawsan Almohammed, Sebastian Tade Barwich, Andrew K. Mitchell, Brian J. Rodriguez, James H. Rice Enhanced photocatalysis and biomolecular sensing with field-activated nanotube-nanoparticle templates published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10393-9	Nature Communications 10/1	2020-02-06
2017	Denise Denning, Jason I Kilpatrick, Eiichi Fukada, Nan Zhang, Stefan Habelitz, Andrzej Fertala, Michael Gilchrist, Yuqi Zhang, Syed A. M. Tofail, Brian J. Rodriguez The piezoelectric tensor of collagen fibrils determined at the nanoscale published pages: 929-935, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.7b00183	ACS Biomaterials Science & Engineering 3	2020-02-06
2016	I. Argatov and G. Mishuris Articular Contact Mechanics from an Asymptotic Modeling Perspective: A Review published pages: 83: 1-9, ISSN: 2296-4185, DOI: 10.3389/fbioe.2016.00083	Front. Bioeng. Biotechnol. 4	2020-02-06
2018	Daniel Peck, Michal Wrobel, Monika Perkowska, Gennady Mishuris Fluid velocity based simulation of hydraulic fracture: a penny shaped modelâ€”part I: the numerical algorithm published pages: 3615-3635, ISSN: 0025-6455, DOI: 10.1007/s11012-018-0899-y	Meccanica 53/15	2020-02-06
2016	G. Vitucci, I. Argatov, G. Mishuris An asymptotic model for the deformation of a transversely isotropic, transversely homogeneous biphasic cartilage layer published pages: n/a-n/a, ISSN: 0170-4214, DOI: 10.1002/mma.3895	Mathematical Methods in the Applied Sciences 28 FEB 2016	2020-02-06
2017	S J Cox, F Graner, R Mosseri and J-F Sadoc Quasicrystalline three-dimensional foams published pages: 114001- 114010, ISSN: 0953-8984, DOI: 10.1088/1361-648X/aa5712	Journal of Physics: Condensed Matter 29	2020-02-06
2016	Ivan Argatov, Gennady Mishuris Pipette aspiration testing of soft tissues: the elastic half-space model revisited published pages: 20160559, ISSN: 1364-5021, DOI: 10.1098/rspa.2016.0559	Proceedings of the Royal Society A: Mathematical, Physical and Engineering Science 472/2193	2020-02-06
2016	I. I. Argatov, G. S. Mishuris, V. L. Popov An Approximate JKR Model of Elliptical Contact Between Thin Incompressible Elastic Coatings Covering Rigid Cylinders published pages: , ISSN: 1023-8883, DOI: 10.1007/s11249-016-0746-z	Tribology Letters 64/1	2020-02-06

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