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GLYCANC

Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GLYCANC project word cloud

Explore the words cloud of the GLYCANC project. It provides you a very rough idea of what is the project "GLYCANC" about.

tumor pharmacological hallmarks basis gag glycanc niches angiogenesis signals stroma hanahan chemokines carbohydrates progression antitumoral pg malignant training population glycans hypothesize modulation immune expression hampered function integrins levels surfaces weinberg entities performing transfer besides proteoglycans pgs aberrant aging shown attractive disease dysregulated microenvironment emerged gags matrix simultaneously 2011 therapeutic cell adhesion applicable acts combined structures interactions multiple anticancer cells itself extensive underlying players glycan modulate rational deeper structural emerges extracellular complexity mechanisms cancer analysing metastasis integrate methodology dependent stem mortality survival structurally biomarkers elucidating regulation multitargeted micrornas epigenetic molecular diverse expertise glycosaminoglycans

Project "GLYCANC" data sheet

The following table provides information about the project.

Coordinator	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://campus.uni-muenster.de/glycanc/start/
Project website	https://campus.uni-muenster.de/glycanc/projekt/forschung/
Total cost	567˙000 €
EC max contribution	567˙000 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2014
Funding Scheme	MSCA-RISE
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	coordinator	103˙500.00
2	UNIVERSITA DEGLI STUDI DELL'INSUBRIA UNIVERSITA DEGLI STUDI DELL'INSUBRIA Organization address address: VIA RAVASI 2 city: VARESE postcode: 21100 website: www.uninsubria.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VARESE)	participant	126˙000.00
3	PANEPISTIMIO PATRON PANEPISTIMIO PATRON Organization address address: UNIVERSITY CAMPUS RIO PATRAS city: RIO PATRAS postcode: 265 04 website: www.upatras.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (RIO PATRAS)	participant	103˙500.00
4	SEMMELWEIS EGYETEM SEMMELWEIS EGYETEM Organization address address: ULLOI UTCA 26 city: BUDAPEST postcode: 1085 website: www.sote.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (BUDAPEST)	participant	67˙500.00
5	"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" Organization address address: END OF PATRIARCHOU GRIGORIOU E AND 27 NEAPOLEOS STREET city: AGIA PARASKEVI postcode: 15341 website: www.demokritos.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (AGIA PARASKEVI)	participant	45˙000.00
6	UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE Organization address address: BOULEVARD DE LA PAIX 9 VILLA DOUCE city: REIMS postcode: 51100 website: http://www.univ-reims.fr/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (REIMS)	participant	45˙000.00
7	UPPSALA UNIVERSITET UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	participant	45˙000.00
8	FIDIA FARMACEUTICI SPA FIDIA FARMACEUTICI SPA Organization address address: via Ponte della Fabbrica 3/a city: Abano Terme postcode: 35031 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Abano Terme)	participant	27˙000.00
9	SEREND-IP GMBH SEREND-IP GMBH Organization address address: ROSTOCKWEG 25 city: MUENSTER postcode: 48147 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	4˙500.00
10	CAIRO UNIVERSITY CAIRO UNIVERSITY Organization address address: AL ORMAN GUIZA city: GIZA postcode: 12613 website: www.cairo.eun.eg contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EG (GIZA)	partner	0.00
11	CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) Organization address address: GODOY CRUZ 2290 city: BUENOS AIRES postcode: C1425FQB website: www.conicet.gov.ar contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AR (BUENOS AIRES)	partner	0.00
12	EWHA WOMANS UNIVERSITY EWHA WOMANS UNIVERSITY Organization address address: 52 Ewhayeodae-gil Seodaemun-gu city: Seoul postcode: 120 750 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	KR (Seoul)	partner	0.00
13	UNIVERSIDADE FEDERAL DO RIO DE JANEIRO UNIVERSIDADE FEDERAL DO RIO DE JANEIRO Organization address address: AV BRIGADEIRO TROMPOWSKI SN 2 city: RIO DE JANEIRO postcode: 21941 590 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BR (RIO DE JANEIRO)	partner	0.00

Map

Project objective

Cancer is a leading cause of mortality within the aging European population. Therapeutic targeting is hampered by the complexity of the disease, which includes not only molecular changes within the tumor cell itself, but also within its microenvironment. Tumor angiogenesis, tumor-stroma interactions, interactions with immune cells, with the extracellular matrix and cancer stem cell niches allow for malignant cell survival and promote metastasis, the leading cause for cancer-associated mortality. Proteoglycans (PGs) and glycosaminoglycans (GAGs) – structurally diverse carbohydrates of the extracellular matrix and cell surfaces - have emerged as novel biomarkers and molecular players both within tumor cells and their microenvironment, as they integrate signals from growth factors, chemokines and integrins, and cell-cell as well as matrix adhesion. Importantly, their expression is dysregulated in numerous tumor entities, and has been shown to modulate each of the hallmarks of cancer as defined by Hanahan and Weinberg (Cell 2011). We hypothesize that dysregulated function of PGs and GAGs simultaneously affects all molecular steps towards cancer metastasis as a general principle applicable to multiple tumor entities. Pharmacological modulation of their function thus emerges as an attractive multitargeted antitumoral approach which simultaneously acts at multiple levels of disease progression. Besides providing extensive knowledge transfer and training for researchers, the combined expertise of the GLYCANC consortium aims at performing a detailed structural analysis of PG and GAG glycans in disease using state-of-the art methodology, analysing their regulation via epigenetic mechanisms and microRNAs, and elucidating molecular mechanisms underlying aberrant PG and GAG function. GLYCANC will lead to a deeper understanding of glycan structures and glycan-dependent mechanisms promoting cancer progression, providing the basis for rational multitargeted anticancer approaches.

Deliverables

List of deliverables.
Chemotherapeutic resistance	Documents, reports	2020-01-28 11:49:34
In vitro analysis of microRNA-dependent Syndecan-1 regulation in IBC	Documents, reports	2020-01-28 11:49:34
Mechanistic in vitro investigation of Syndecan-dependenttranscriptional activation	Documents, reports	2020-01-28 11:49:34
Inhibitory effect of 4- MU in vivo	Documents, reports	2020-01-28 11:49:34
Analysis of signaling pathways	Documents, reports	2020-01-28 11:49:34
Methods for preprocessing and processing of spectral data	Documents, reports	2020-01-28 11:49:34
In vitro functional assays in a novel 3D culture system	Documents, reports	2020-01-28 11:49:33
Functional in vitro studies	Documents, reports	2020-01-28 11:49:33
In vivo study on the premetastatic niche	Documents, reports	2020-01-28 11:49:33
Immune cells in the microenvironment	Documents, reports	2020-01-28 11:49:33
Angiogenesis regulators	Documents, reports	2020-01-28 11:49:33
Nanostic analysis	Documents, reports	2020-01-28 11:49:33
Role of Syndecan-1 oligomerization in FAK activation	Documents, reports	2020-01-28 11:49:33
Proof of concept for in vivo Raman probes for diagnosis of melanoma in patients and application to tumor-associated macrophages	Documents, reports	2020-01-28 11:49:34
Analysis of angiogenic factors in immunomodulatory cells	Documents, reports	2020-01-28 11:49:33
3D culture	Documents, reports	2020-01-28 11:49:33
Functional impact of miRNA-dependent PG and HAS regulation	Documents, reports	2020-01-28 11:49:33
Microvascular density	Documents, reports	2020-01-28 11:49:33
Role of PGs in TGFbeta induced EMT	Documents, reports	2020-01-28 11:49:33
Therapeutic potential of Ascidian GAGs	Documents, reports	2020-01-28 11:49:33
Characterization of HA molecular weight from tumor and control tissue of at least three in vivo mouse tumor models	Documents, reports	2020-01-28 11:49:33
ChIP experiments	Documents, reports	2020-01-28 11:49:33
Impact of conventional therapeutics on the premetastatic niche	Documents, reports	2020-01-28 11:49:31
microRNA-regulation of Syndecan-1 in clinical IBC specimens	Documents, reports	2020-01-28 11:49:29
In vitro study of the premetastatic niche	Documents, reports	2020-01-28 11:49:31
Changes in EMT marker expression	Documents, reports	2020-01-28 11:49:31
Impact of PGs and GAGs on premature senescence of cancer cells	Documents, reports	2020-01-28 11:49:30
Characterization of HS disaccharide structure from 8 breast cancer cell lines with altered Syndecan-1, 3-O-HS sulfation and 2-O-HS sulfation	Documents, reports	2020-01-28 11:49:29
Epigenetic HAS2 promoter regulation	Documents, reports	2020-01-28 11:49:30
Workshop on epigenetic regulation	Websites, patent fillings, videos etc.	2020-01-28 11:49:30
Workshop on PGs and GAGs in metastasis	Websites, patent fillings, videos etc.	2020-01-28 11:49:31
Diagnostic value of Syndecan-1 in IBC	Documents, reports	2020-01-28 11:49:31
In vivo model of hepatocarcinogenesis	Documents, reports	2020-01-28 11:49:29
microRNA regulation of Glypican-1, Syndecan-2 and HAS1-3 in breast and colon cancer	Documents, reports	2020-01-28 11:49:29
Flow cytometric analysis of SP and ALDH phenotype	Documents, reports	2020-01-28 11:49:30
Standardized Protocol for Tissue Microarray Analysis by FTIR and RAMAN spectroscopy	Documents, reports	2020-01-28 11:49:32
Evaluation of HA related enzyme expression	Documents, reports	2020-01-28 11:49:31
Standardized protocol for FTIR and RAMAN spectroscopic analysis of GAGs in cells and conditioned media.	Documents, reports	2020-01-28 11:49:30
Impact of PG/HA on DNA damage response	Documents, reports	2020-01-28 11:49:30
qPCR analysis of angiogenic factors in tumors	Documents, reports	2020-01-28 11:49:31
Flow cytometric and qPCR analysis of stem cell markers	Documents, reports	2020-01-28 11:49:32
Correlation of GAG structure with clinicopathological parameters	Documents, reports	2020-01-28 11:49:31
Proof of concept to determine GAGs composition in cancer stromal tissue	Documents, reports	2020-01-28 11:49:32
Spectroscopic delineation of the expression of GAGs in mice lung metastatic nodules	Documents, reports	2020-01-28 11:49:32
Establichment of GLYCANC Website	Websites, patent fillings, videos etc.	2020-01-28 11:49:31
Spectroscopic delineation of the expression of GAGs in murine melanoma, and PG-manuipulated cancer cell lines	Documents, reports	2020-01-28 11:49:31
Changes in invasive behaviour	Documents, reports	2020-01-28 11:49:31
Analysis of glioblastoma cell line GAG structure	Documents, reports	2020-01-28 11:49:31

Take a look to the deliverables list in detail: detailed list of GLYCANC deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Alberto Passi, Davide Vigetti, Simone Buraschi, Renato V. Iozzo Dissecting the role of hyaluronan synthases in the tumor microenvironment published pages: 2937-2949, ISSN: 1742-464X, DOI: 10.1111/febs.14847	The FEBS Journal 286/15	2020-01-28
2019	Anastasia-Gerasimoula Tavianatou, Zoi Piperigkou, Carlo Barbera, Riccardo Beninatto, Valentina Masola, Ilaria Caon, Maurizio Onisto, Marco Franchi, Devis Galesso, Nikos K. Karamanos Molecular size-dependent specificity of hyaluronan on functional properties, morphology and matrix composition of mammary cancer cells published pages: 100008, ISSN: 2590-0285, DOI: 10.1016/j.mbplus.2019.100008	Matrix Biology Plus	2020-01-28
2019	Moshira Ezzat Saleh, Ramy Gadalla, Hebatallah Hassan, Ahmed Afifi, Martin GÃ¶tte, Mohamed El-Shinawi, Mona Mostafa Mohamed, Sherif Abdelaziz Ibrahim The immunomodulatory role of tumor Syndecan-1 (CD138) on ex vivo tumor microenvironmental CD4+ T cell polarization in inflammatory and non-inflammatory breast cancer patients published pages: e0217550, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0217550	PLOS ONE 14/5	2020-01-28
2019	Fiorella M. Spinelli, Daiana L. Vitale, Antonella Icardi, Ilaria Caon, Alejandra Brandone, Paula Giannoni, Virginia Saturno, Alberto Passi, Mariana GarcÃa, Ina Sevic, Laura Alaniz Hyaluronan preconditioning of monocytes/macrophages affects their angiogenic behavior and regulation of TSG â€6 expression in a tumor typeâ€specific manner published pages: , ISSN: 1742-464X, DOI: 10.1111/febs.14871	The FEBS Journal	2020-01-28
2018	Martin GÃ¶tte, Ilona Kovalszky Extracellular matrix functions in lung cancer published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.02.018	Matrix Biology	2020-01-28
2018	Theodoros T. Karalis, Paraskevi Heldin, Demitrios H. Vynios, Thomas Neill, Simone Buraschi, Renato V. Iozzo, Nikos K. Karamanos, Spyros S. Skandalis Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.04.007	Matrix Biology	2020-01-28
2018	Daiana L. Vitale, Fiorella M. Spinelli, Daiana Del Dago, Antonella Icardi, Gianina Demarchi, Ilaria Caon, Mariana GarcÃa, Marcela F. Bolontrade, Alberto Passi, Carolina Cristina, Laura Alaniz Co-treatment of tumor cells with hyaluronan plus doxorubicin affects endothelial cell behavior independently of VEGF expression published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.26379	Oncotarget 9/93	2020-01-28
2019	Eszter RegÅ‘s, Katalin KarÃ¡szi, Andrea Reszegi, AndrÃ¡s Kiss, Zsuzsa Schaff, KornÃ©lia Baghy, Ilona Kovalszky Syndecan-1 in Liver Diseases published pages: , ISSN: 1219-4956, DOI: 10.1007/s12253-019-00617-0	Pathology & Oncology Research	2020-01-28
2017	S. BrÃ©zillon, V. Untereiner, H. T. Mohamed, J. Hodin, A. Chatron-Colliet, F.-X. Maquart, G. D. Sockalingum Probing glycosaminoglycan spectral signatures in live cells and their conditioned media by Raman microspectroscopy published pages: 1333-1341, ISSN: 0003-2654, DOI: 10.1039/C6AN01951J	The Analyst 142/8	2020-01-28
2017	Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A. El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed, Martin GÃ¶tte Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways published pages: 57, ISSN: 1476-4598, DOI: 10.1186/s12943-017-0621-z	Molecular Cancer 16/1	2020-01-28
2015	Alexander Schwickert, Esther Weghake, Kathrin BrÃ¼ggemann, Annika Engbers, Benjamin F. Brinkmann, BjÃ¶rn Kemper, Jochen SeggewiÃŸ, Christian Stock, Klaus Ebnet, Ludwig Kiesel, Christoph RiethmÃ¼ller, Martin GÃ¶tte microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements published pages: e0143993, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0143993	PLOS ONE 10/12	2020-01-28
2016	Hossam Taha Mohamed, ValÃ©rie Untereiner, Ganesh D. Sockalingum, StÃ©phane BrÃ©zillon Implementation of infrared and Raman modalities for glycosaminoglycan characterization in complex systems published pages: , ISSN: 0282-0080, DOI: 10.1007/s10719-016-9743-6	Glycoconjugate Journal	2020-01-28
2018	Eszter RegÅ‘s, Hadeer Hesham Abdelfattah, Andrea Reszegi, LÃ¡szlÃ³ SzilÃ¡k, KlÃ¡ra Werling, GÃ¡bor SzabÃ³, AndrÃ¡s Kiss, Zsuzsa Schaff, Ilona Kovalszky, KornÃ©lia Baghy Syndecan-1 inhibits early stages of liver fibrogenesis by interfering with TGFÎ²1 action and upregulating MMP14 published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.02.008	Matrix Biology	2020-01-28
2017	Viviana Filpa, Michela Bistoletti, Ilaria Caon, Elisabetta Moro, Annalisa Grimaldi, Paola Moretto, Andreina Baj, Maria Cecilia Giron, Evgenia Karousou, Manuela Viola, Francesca Crema, Gianmario Frigo, Alberto Passi, Cristina Giaroni, Davide Vigetti Changes in hyaluronan deposition in the rat myenteric plexus after experimentally-induced colitis published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-18020-7	Scientific Reports 7/1	2020-01-28
2017	Konstantina Karamanou, Diana Carolina Restrepo Espinosa, Anneliese Fortuna-Costa, Mauro SÃ©rgio GonÃ§alves PavÃ£o Biological function of unique sulfated glycosaminoglycans in primitive chordates published pages: 277-283, ISSN: 0282-0080, DOI: 10.1007/s10719-016-9728-5	Glycoconjugate Journal 34/3	2020-01-28
2017	Zoi Piperigkou, Martin GÃ¶tte, Achilleas D. Theocharis, Nikos K. Karamanos Insights into the key roles of epigenetics in matrix macromolecules-associated wound healing published pages: , ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.10.008	Advanced Drug Delivery Reviews	2020-01-28
2016	Zoi Piperigkou, Benedikt Mohr, Nikos Karamanos, Martin GÃ¶tte Shed proteoglycans in tumor stroma published pages: , ISSN: 0302-766X, DOI: 10.1007/s00441-016-2452-4	Cell and Tissue Research	2020-01-28
2017	Argyris Spyrou, Soumi Kundu, Lulu Haseeb, Di Yu, Tommie Olofsson, Keith Dredge, Edward Hammond, Uri Barash, Israel Vlodavsky, Karin Forsberg-Nilsson Inhibition of Heparanase in Pediatric Brain Tumor Cells Attenuates their Proliferation, Invasive Capacity, and In Vivo Tumor Growth published pages: 1705-1716, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-16-0900	Molecular Cancer Therapeutics 16/8	2020-01-28
2017	Nikolaos A. Afratis, Panagiotis Bouris, Spyros S. Skandalis, Hinke A. Multhaupt, John R. Couchman, Achilleas D. Theocharis, Nikos K. Karamanos IGF-IR cooperates with ERÎ± to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules published pages: 40138, ISSN: 2045-2322, DOI: 10.1038/srep40138	Scientific Reports 7	2020-01-28
2017	Eleni Mavrogonatou, Harris Pratsinis, Adamantia Papadopoulou, Nikos K. Karamanos, Dimitris Kletsas Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2017.10.004	Matrix Biology	2020-01-28
2017	Evgenia Karousou, Suniti Misra, Shibnath Ghatak, Katalin Dobra, Martin GÃ¶tte, Davide Vigetti, Alberto Passi, Nikos K. Karamanos, Spyros S. Skandalis Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer published pages: 3-22, ISSN: 0945-053X, DOI: 10.1016/j.matbio.2016.10.001	Matrix Biology 59	2020-01-28
2017	Manuela Viola, Kathrin BrÃ¼ggemann, Evgenia Karousou, Ilaria Caon, Elena CaravÃ , Davide Vigetti, Burkhard Greve, Christian Stock, Giancarlo De Luca, Alberto Passi, Martin GÃ¶tte MDA-MB-231 breast cancer cell viability, motility and matrix adhesion are regulated by a complex interplay of heparan sulfate, chondroitinâˆ’/dermatan sulfate and hyaluronan biosynthesis published pages: 411-420, ISSN: 0282-0080, DOI: 10.1007/s10719-016-9735-6	Glycoconjugate Journal 34/3	2020-01-28
2017	Zoi Piperigkou, Marco Franchi, Martin GÃ¶tte, Nikos K. Karamanos Estrogen receptor beta as epigenetic mediator of miR-10b and miR-145 in mammary cancer published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2017.08.002	Matrix Biology	2020-01-28
2019	Moshira Ezzat Saleh, Ramy Gadalla, Hebatallah Hassan, Ahmed Afifi, Martin GÃ¶tte, Mohamed El-Shinawi, Mona Mostafa Mohamed, Sherif Abdelaziz Ibrahim The immunomodulatory role of tumor Syndecan-1 (CD138) on ex vivo tumor microenvironmental CD4+ T cell polarization in inflammatory and non-inflammatory breast cancer patients published pages: e0217550, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0217550	PLOS ONE 14/5	2020-01-28

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