Explore the words cloud of the GLYCANC project. It provides you a very rough idea of what is the project "GLYCANC" about.
The following table provides information about the project.
Coordinator |
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Organization address contact info |
Coordinator Country | Germany [DE] |
Project website | https://campus.uni-muenster.de/glycanc/start/ |
Project website | https://campus.uni-muenster.de/glycanc/projekt/forschung/ |
Total cost | 567˙000 € |
EC max contribution | 567˙000 € (100%) |
Programme |
1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge) |
Code Call | H2020-MSCA-RISE-2014 |
Funding Scheme | MSCA-RISE |
Starting year | 2015 |
Duration (year-month-day) | from 2015-07-01 to 2019-06-30 |
Take a look of project's partnership.
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1 | WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER | DE (MUENSTER) | coordinator | 103˙500.00 |
2 | UNIVERSITA DEGLI STUDI DELL'INSUBRIA | IT (VARESE) | participant | 126˙000.00 |
3 | PANEPISTIMIO PATRON | EL (RIO PATRAS) | participant | 103˙500.00 |
4 | SEMMELWEIS EGYETEM | HU (BUDAPEST) | participant | 67˙500.00 |
5 | "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" | EL (AGIA PARASKEVI) | participant | 45˙000.00 |
6 | UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE | FR (REIMS) | participant | 45˙000.00 |
7 | UPPSALA UNIVERSITET | SE (UPPSALA) | participant | 45˙000.00 |
8 | FIDIA FARMACEUTICI SPA | IT (Abano Terme) | participant | 27˙000.00 |
9 | SEREND-IP GMBH | DE (MUENSTER) | participant | 4˙500.00 |
10 | CAIRO UNIVERSITY | EG (GIZA) | partner | 0.00 |
11 | CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) | AR (BUENOS AIRES) | partner | 0.00 |
12 | EWHA WOMANS UNIVERSITY | KR (Seoul) | partner | 0.00 |
13 | UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | BR (RIO DE JANEIRO) | partner | 0.00 |
Cancer is a leading cause of mortality within the aging European population. Therapeutic targeting is hampered by the complexity of the disease, which includes not only molecular changes within the tumor cell itself, but also within its microenvironment. Tumor angiogenesis, tumor-stroma interactions, interactions with immune cells, with the extracellular matrix and cancer stem cell niches allow for malignant cell survival and promote metastasis, the leading cause for cancer-associated mortality. Proteoglycans (PGs) and glycosaminoglycans (GAGs) – structurally diverse carbohydrates of the extracellular matrix and cell surfaces - have emerged as novel biomarkers and molecular players both within tumor cells and their microenvironment, as they integrate signals from growth factors, chemokines and integrins, and cell-cell as well as matrix adhesion. Importantly, their expression is dysregulated in numerous tumor entities, and has been shown to modulate each of the hallmarks of cancer as defined by Hanahan and Weinberg (Cell 2011). We hypothesize that dysregulated function of PGs and GAGs simultaneously affects all molecular steps towards cancer metastasis as a general principle applicable to multiple tumor entities. Pharmacological modulation of their function thus emerges as an attractive multitargeted antitumoral approach which simultaneously acts at multiple levels of disease progression. Besides providing extensive knowledge transfer and training for researchers, the combined expertise of the GLYCANC consortium aims at performing a detailed structural analysis of PG and GAG glycans in disease using state-of-the art methodology, analysing their regulation via epigenetic mechanisms and microRNAs, and elucidating molecular mechanisms underlying aberrant PG and GAG function. GLYCANC will lead to a deeper understanding of glycan structures and glycan-dependent mechanisms promoting cancer progression, providing the basis for rational multitargeted anticancer approaches.
Chemotherapeutic resistance | Documents, reports | 2020-01-28 11:49:34 |
In vitro analysis of microRNA-dependent Syndecan-1 regulation in IBC | Documents, reports | 2020-01-28 11:49:34 |
Mechanistic in vitro investigation of Syndecan-dependenttranscriptional activation | Documents, reports | 2020-01-28 11:49:34 |
Inhibitory effect of 4- MU in vivo | Documents, reports | 2020-01-28 11:49:34 |
Analysis of signaling pathways | Documents, reports | 2020-01-28 11:49:34 |
Methods for preprocessing and processing of spectral data | Documents, reports | 2020-01-28 11:49:34 |
In vitro functional assays in a novel 3D culture system | Documents, reports | 2020-01-28 11:49:33 |
Functional in vitro studies | Documents, reports | 2020-01-28 11:49:33 |
In vivo study on the premetastatic niche | Documents, reports | 2020-01-28 11:49:33 |
Immune cells in the microenvironment | Documents, reports | 2020-01-28 11:49:33 |
Angiogenesis regulators | Documents, reports | 2020-01-28 11:49:33 |
Nanostic analysis | Documents, reports | 2020-01-28 11:49:33 |
Role of Syndecan-1 oligomerization in FAK activation | Documents, reports | 2020-01-28 11:49:33 |
Proof of concept for in vivo Raman probes for diagnosis of melanoma in patients and application to tumor-associated macrophages | Documents, reports | 2020-01-28 11:49:34 |
Analysis of angiogenic factors in immunomodulatory cells | Documents, reports | 2020-01-28 11:49:33 |
3D culture | Documents, reports | 2020-01-28 11:49:33 |
Functional impact of miRNA-dependent PG and HAS regulation | Documents, reports | 2020-01-28 11:49:33 |
Microvascular density | Documents, reports | 2020-01-28 11:49:33 |
Role of PGs in TGFbeta induced EMT | Documents, reports | 2020-01-28 11:49:33 |
Therapeutic potential of Ascidian GAGs | Documents, reports | 2020-01-28 11:49:33 |
Characterization of HA molecular weight from tumor and control tissue of at least three in vivo mouse tumor models | Documents, reports | 2020-01-28 11:49:33 |
ChIP experiments | Documents, reports | 2020-01-28 11:49:33 |
Impact of conventional therapeutics on the premetastatic niche | Documents, reports | 2020-01-28 11:49:31 |
microRNA-regulation of Syndecan-1 in clinical IBC specimens | Documents, reports | 2020-01-28 11:49:29 |
In vitro study of the premetastatic niche | Documents, reports | 2020-01-28 11:49:31 |
Changes in EMT marker expression | Documents, reports | 2020-01-28 11:49:31 |
Impact of PGs and GAGs on premature senescence of cancer cells | Documents, reports | 2020-01-28 11:49:30 |
Characterization of HS disaccharide structure from 8 breast cancer cell lines with altered Syndecan-1, 3-O-HS sulfation and 2-O-HS sulfation | Documents, reports | 2020-01-28 11:49:29 |
Epigenetic HAS2 promoter regulation | Documents, reports | 2020-01-28 11:49:30 |
Workshop on epigenetic regulation | Websites, patent fillings, videos etc. | 2020-01-28 11:49:30 |
Workshop on PGs and GAGs in metastasis | Websites, patent fillings, videos etc. | 2020-01-28 11:49:31 |
Diagnostic value of Syndecan-1 in IBC | Documents, reports | 2020-01-28 11:49:31 |
In vivo model of hepatocarcinogenesis | Documents, reports | 2020-01-28 11:49:29 |
microRNA regulation of Glypican-1, Syndecan-2 and HAS1-3 in breast and colon cancer | Documents, reports | 2020-01-28 11:49:29 |
Flow cytometric analysis of SP and ALDH phenotype | Documents, reports | 2020-01-28 11:49:30 |
Standardized Protocol for Tissue Microarray Analysis by FTIR and RAMAN spectroscopy | Documents, reports | 2020-01-28 11:49:32 |
Evaluation of HA related enzyme expression | Documents, reports | 2020-01-28 11:49:31 |
Standardized protocol for FTIR and RAMAN spectroscopic analysis of GAGs in cells and conditioned media. | Documents, reports | 2020-01-28 11:49:30 |
Impact of PG/HA on DNA damage response | Documents, reports | 2020-01-28 11:49:30 |
qPCR analysis of angiogenic factors in tumors | Documents, reports | 2020-01-28 11:49:31 |
Flow cytometric and qPCR analysis of stem cell markers | Documents, reports | 2020-01-28 11:49:32 |
Correlation of GAG structure with clinicopathological parameters | Documents, reports | 2020-01-28 11:49:31 |
Proof of concept to determine GAGs composition in cancer stromal tissue | Documents, reports | 2020-01-28 11:49:32 |
Spectroscopic delineation of the expression of GAGs in mice lung metastatic nodules | Documents, reports | 2020-01-28 11:49:32 |
Establichment of GLYCANC Website | Websites, patent fillings, videos etc. | 2020-01-28 11:49:31 |
Spectroscopic delineation of the expression of GAGs in murine melanoma, and PG-manuipulated cancer cell lines | Documents, reports | 2020-01-28 11:49:31 |
Changes in invasive behaviour | Documents, reports | 2020-01-28 11:49:31 |
Analysis of glioblastoma cell line GAG structure | Documents, reports | 2020-01-28 11:49:31 |
Take a look to the deliverables list in detail: detailed list of GLYCANC deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Alberto Passi, Davide Vigetti, Simone Buraschi, Renato V. Iozzo Dissecting the role of hyaluronan synthases in the tumor microenvironment published pages: 2937-2949, ISSN: 1742-464X, DOI: 10.1111/febs.14847 |
The FEBS Journal 286/15 | 2020-01-28 |
2019 |
Anastasia-Gerasimoula Tavianatou, Zoi Piperigkou, Carlo Barbera, Riccardo Beninatto, Valentina Masola, Ilaria Caon, Maurizio Onisto, Marco Franchi, Devis Galesso, Nikos K. Karamanos Molecular size-dependent specificity of hyaluronan on functional properties, morphology and matrix composition of mammary cancer cells published pages: 100008, ISSN: 2590-0285, DOI: 10.1016/j.mbplus.2019.100008 |
Matrix Biology Plus | 2020-01-28 |
2019 |
Moshira Ezzat Saleh, Ramy Gadalla, Hebatallah Hassan, Ahmed Afifi, Martin Götte, Mohamed El-Shinawi, Mona Mostafa Mohamed, Sherif Abdelaziz Ibrahim The immunomodulatory role of tumor Syndecan-1 (CD138) on ex vivo tumor microenvironmental CD4+ T cell polarization in inflammatory and non-inflammatory breast cancer patients published pages: e0217550, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0217550 |
PLOS ONE 14/5 | 2020-01-28 |
2019 |
Fiorella M. Spinelli, Daiana L. Vitale, Antonella Icardi, Ilaria Caon, Alejandra Brandone, Paula Giannoni, Virginia Saturno, Alberto Passi, Mariana GarcÃa, Ina Sevic, Laura Alaniz Hyaluronan preconditioning of monocytes/macrophages affects their angiogenic behavior and regulation of TSG â€6 expression in a tumor typeâ€specific manner published pages: , ISSN: 1742-464X, DOI: 10.1111/febs.14871 |
The FEBS Journal | 2020-01-28 |
2018 |
Martin Götte, Ilona Kovalszky Extracellular matrix functions in lung cancer published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.02.018 |
Matrix Biology | 2020-01-28 |
2018 |
Theodoros T. Karalis, Paraskevi Heldin, Demitrios H. Vynios, Thomas Neill, Simone Buraschi, Renato V. Iozzo, Nikos K. Karamanos, Spyros S. Skandalis Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.04.007 |
Matrix Biology | 2020-01-28 |
2018 |
Daiana L. Vitale, Fiorella M. Spinelli, Daiana Del Dago, Antonella Icardi, Gianina Demarchi, Ilaria Caon, Mariana GarcÃa, Marcela F. Bolontrade, Alberto Passi, Carolina Cristina, Laura Alaniz Co-treatment of tumor cells with hyaluronan plus doxorubicin affects endothelial cell behavior independently of VEGF expression published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.26379 |
Oncotarget 9/93 | 2020-01-28 |
2019 |
Eszter Regős, Katalin Karászi, Andrea Reszegi, András Kiss, Zsuzsa Schaff, Kornélia Baghy, Ilona Kovalszky Syndecan-1 in Liver Diseases published pages: , ISSN: 1219-4956, DOI: 10.1007/s12253-019-00617-0 |
Pathology & Oncology Research | 2020-01-28 |
2017 |
S. Brézillon, V. Untereiner, H. T. Mohamed, J. Hodin, A. Chatron-Colliet, F.-X. Maquart, G. D. Sockalingum Probing glycosaminoglycan spectral signatures in live cells and their conditioned media by Raman microspectroscopy published pages: 1333-1341, ISSN: 0003-2654, DOI: 10.1039/C6AN01951J |
The Analyst 142/8 | 2020-01-28 |
2017 |
Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A. El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed, Martin Götte Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways published pages: 57, ISSN: 1476-4598, DOI: 10.1186/s12943-017-0621-z |
Molecular Cancer 16/1 | 2020-01-28 |
2015 |
Alexander Schwickert, Esther Weghake, Kathrin Brüggemann, Annika Engbers, Benjamin F. Brinkmann, Björn Kemper, Jochen Seggewiß, Christian Stock, Klaus Ebnet, Ludwig Kiesel, Christoph Riethmüller, Martin Götte microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements published pages: e0143993, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0143993 |
PLOS ONE 10/12 | 2020-01-28 |
2016 |
Hossam Taha Mohamed, Valérie Untereiner, Ganesh D. Sockalingum, Stéphane Brézillon Implementation of infrared and Raman modalities for glycosaminoglycan characterization in complex systems published pages: , ISSN: 0282-0080, DOI: 10.1007/s10719-016-9743-6 |
Glycoconjugate Journal | 2020-01-28 |
2018 |
Eszter Regős, Hadeer Hesham Abdelfattah, Andrea Reszegi, László Szilák, Klára Werling, Gábor Szabó, András Kiss, Zsuzsa Schaff, Ilona Kovalszky, Kornélia Baghy Syndecan-1 inhibits early stages of liver fibrogenesis by interfering with TGFβ1 action and upregulating MMP14 published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.02.008 |
Matrix Biology | 2020-01-28 |
2017 |
Viviana Filpa, Michela Bistoletti, Ilaria Caon, Elisabetta Moro, Annalisa Grimaldi, Paola Moretto, Andreina Baj, Maria Cecilia Giron, Evgenia Karousou, Manuela Viola, Francesca Crema, Gianmario Frigo, Alberto Passi, Cristina Giaroni, Davide Vigetti Changes in hyaluronan deposition in the rat myenteric plexus after experimentally-induced colitis published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-18020-7 |
Scientific Reports 7/1 | 2020-01-28 |
2017 |
Konstantina Karamanou, Diana Carolina Restrepo Espinosa, Anneliese Fortuna-Costa, Mauro Sérgio Gonçalves Pavão Biological function of unique sulfated glycosaminoglycans in primitive chordates published pages: 277-283, ISSN: 0282-0080, DOI: 10.1007/s10719-016-9728-5 |
Glycoconjugate Journal 34/3 | 2020-01-28 |
2017 |
Zoi Piperigkou, Martin Götte, Achilleas D. Theocharis, Nikos K. Karamanos Insights into the key roles of epigenetics in matrix macromolecules-associated wound healing published pages: , ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.10.008 |
Advanced Drug Delivery Reviews | 2020-01-28 |
2016 |
Zoi Piperigkou, Benedikt Mohr, Nikos Karamanos, Martin Götte Shed proteoglycans in tumor stroma published pages: , ISSN: 0302-766X, DOI: 10.1007/s00441-016-2452-4 |
Cell and Tissue Research | 2020-01-28 |
2017 |
Argyris Spyrou, Soumi Kundu, Lulu Haseeb, Di Yu, Tommie Olofsson, Keith Dredge, Edward Hammond, Uri Barash, Israel Vlodavsky, Karin Forsberg-Nilsson Inhibition of Heparanase in Pediatric Brain Tumor Cells Attenuates their Proliferation, Invasive Capacity, and In Vivo Tumor Growth published pages: 1705-1716, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-16-0900 |
Molecular Cancer Therapeutics 16/8 | 2020-01-28 |
2017 |
Nikolaos A. Afratis, Panagiotis Bouris, Spyros S. Skandalis, Hinke A. Multhaupt, John R. Couchman, Achilleas D. Theocharis, Nikos K. Karamanos IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules published pages: 40138, ISSN: 2045-2322, DOI: 10.1038/srep40138 |
Scientific Reports 7 | 2020-01-28 |
2017 |
Eleni Mavrogonatou, Harris Pratsinis, Adamantia Papadopoulou, Nikos K. Karamanos, Dimitris Kletsas Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2017.10.004 |
Matrix Biology | 2020-01-28 |
2017 |
Evgenia Karousou, Suniti Misra, Shibnath Ghatak, Katalin Dobra, Martin Götte, Davide Vigetti, Alberto Passi, Nikos K. Karamanos, Spyros S. Skandalis Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer published pages: 3-22, ISSN: 0945-053X, DOI: 10.1016/j.matbio.2016.10.001 |
Matrix Biology 59 | 2020-01-28 |
2017 |
Manuela Viola, Kathrin Brüggemann, Evgenia Karousou, Ilaria Caon, Elena Caravà , Davide Vigetti, Burkhard Greve, Christian Stock, Giancarlo De Luca, Alberto Passi, Martin Götte MDA-MB-231 breast cancer cell viability, motility and matrix adhesion are regulated by a complex interplay of heparan sulfate, chondroitin−/dermatan sulfate and hyaluronan biosynthesis published pages: 411-420, ISSN: 0282-0080, DOI: 10.1007/s10719-016-9735-6 |
Glycoconjugate Journal 34/3 | 2020-01-28 |
2017 |
Zoi Piperigkou, Marco Franchi, Martin Götte, Nikos K. Karamanos Estrogen receptor beta as epigenetic mediator of miR-10b and miR-145 in mammary cancer published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2017.08.002 |
Matrix Biology | 2020-01-28 |
2019 |
Moshira Ezzat Saleh, Ramy Gadalla, Hebatallah Hassan, Ahmed Afifi, Martin Götte, Mohamed El-Shinawi, Mona Mostafa Mohamed, Sherif Abdelaziz Ibrahim The immunomodulatory role of tumor Syndecan-1 (CD138) on ex vivo tumor microenvironmental CD4+ T cell polarization in inflammatory and non-inflammatory breast cancer patients published pages: e0217550, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0217550 |
PLOS ONE 14/5 | 2020-01-28 |
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Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
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The information about "GLYCANC" are provided by the European Opendata Portal: CORDIS opendata.
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