#	Pagina
attuale pagina	/open-h2020/projects/194498/index.html

Opendata, web and dolomites

DIvA SIGNED

Chromatin function in DNA Double Strand breaks repair: Prime, repair and restore DSB Inducible via AsiSI

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

DIvA project word cloud

Explore the words cloud of the DIvA project. It provides you a very rough idea of what is the project "DIvA" about.

code faithfully influences remodeling integrity types variety hinders genome experimental describe chromosomes inducible damaged elucidate nucleus sequence prime scar chromatin restore relationship deleterious mechanisms breaks strands events occurs thoroughly unknown genomic asisi firstly reorganization double diseases technologies histone dsb epigenome landscape damage reorganized break defects restored illustrated once multiple uncovered raises structure environment picture dsbs cell complete questions awaited packaging diva regulates machineries concomitantly proteomic secondly induction contribution throughput initial human fate context spatial stability dna understand modifications detection repair

Project "DIvA" data sheet

The following table provides information about the project.

Coordinator	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	2˙000˙000 €
EC max contribution	2˙000˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	2˙000˙000.00

Map

Project objective

'Among the types of damage, DNA Double Strands Breaks (DSBs) are the most deleterious, as illustrated by the variety of human diseases associated with DSB repair defects. Repair of DSB into the chromatin context raises several questions that we aim to address in this proposal. Firstly, it is likely that the chromatin environment where a break occurs influences the choice of repair pathway. Since the different DSB repair mechanisms can lead to different 'scar' on the genome, further studies are required to elucidate how chromatin structure regulates the targeting of DSB repair machineries. Secondly, DNA packaging into chromatin hinders detection and repair of DSBs and many chromatin modifications were recently identified as induced around DSBs to facilitate repair. However, a complete picture of the chromatin landscape set up at DSB, and more specifically the set of histone modifications associated with each repair pathway ('repair histone code') is still awaited. In addition, whether and how damaged chromosomes are reorganized within the nucleus is still unknown. Finally, once repair has been completed, the initial chromatin landscape must be faithfully restored in order to maintain epigenome stability and cell fate. Using an experimental system we recently developed (called DIvA for DSB Inducible via AsiSI), that allows the induction of multiple sequence-specific DSBs widespread across the genome, we propose to investigate these uncovered aspects of the relationship between chromatin and DSB repair. By high-throughput genomic and proteomic technologies, we will try (i) to understand the contribution of chromatin in the DSB repair pathway choice (PRIME), (ii) to describe more thoroughly the chromatin remodeling events and the spatial chromosomes reorganization, that occur concomitantly to DSB to promote adequate repair (REPAIR), and (iii) to elucidate the processes at work to restore epigenome integrity after DSB repair (RESTORE). '

Publications

List of publications.
year	authors and title	journal	last update
2017	Aude GuÃ©nolÃ©, GaÃ«lle Legube A meeting at risk: Unrepaired DSBs go for broke published pages: 589-599, ISSN: 1949-1034, DOI: 10.1080/19491034.2017.1380138	Nucleus 8/6	2020-03-20
2017	Thomas Clouaire, Aline Marnef, GaÃ«lle Legube Taming Tricky DSBs: ATM on duty published pages: 84-91, ISSN: 1568-7864, DOI: 10.1016/j.dnarep.2017.06.010	DNA Repair 56	2020-03-20
2017	FranÃ§ois Aymard, Marion Aguirrebengoa, Emmanuelle Guillou, Biola M Javierre, Beatrix Bugler, Coline Arnould, Vincent Rocher, Jason S Iacovoni, Anna Biernacka, Magdalena Skrzypczak, Krzysztof Ginalski, Maga Rowicka, Peter Fraser, GaÃ«lle Legube Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes published pages: 353-361, ISSN: 1545-9993, DOI: 10.1038/nsmb.3387	Nature Structural & Molecular Biology 24/4	2020-03-20
2018	Sarah Cohen, Nadine Puget, Yea-Lih Lin, Thomas Clouaire, Marion Aguirrebengoa, Vincent Rocher, Philippe Pasero, Yvan Canitrot, GaÃ«lle Legube Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-02894-w	Nature Communications 9/1	2020-03-20
2015	Pierre Caron, Jonathan Choudjaye, Thomas Clouaire, BÃ©atrix Bugler, Virginie Daburon, Marion Aguirrebengoa, Thomas Mangeat, JasonÂ S. Iacovoni, Alejandro Ãlvarez-QuilÃ³n, Felipe CortÃ©s-Ledesma, GaÃ«lle Legube Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks published pages: 1598-1609, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2015.10.024	Cell Reports 13/8	2020-03-20
2015	Francois Aymard, GaÃ«lle Legube A TAD closer to ATM published pages: e1134411, ISSN: 2372-3556, DOI: 10.1080/23723556.2015.1134411	Molecular & Cellular Oncology 3/3	2020-03-20

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DIVA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DIVA" are provided by the European Opendata Portal: CORDIS opendata.