gluactive SIGNED
Activation Mechanism of a Glutamate Receptor
Total Cost €
0EC-Contrib. €
0Partnership
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Project "gluactive" data sheet
The following table provides information about the project.
| Coordinator |
FORSCHUNGSVERBUND BERLIN EV
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 1˙981˙500 € |
| EC max contribution | 1˙981˙500 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-07-01 to 2020-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | FORSCHUNGSVERBUND BERLIN EV | DE (BERLIN) | coordinator | 1˙981˙500.00 |
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Project objective
Glutamate receptors are amongst the most important signalling molecules in the brain. Activation of receptors by the neurotransmitter glutamate is required for nervous system function, underlying cognition, learning, memory and sensation. Despite advances in the study of their structural biology and physiology, how glutamate receptor complexes are activated remains unclear. With this proposal, we aim to determine how receptor activation and desensitisation are driven by glutamate binding. Our central approach is to map the motions of glutamate receptors during synaptic-like activity, in order to grab the frames needed to produce the movie of receptor activation. We aim to detect motion within the receptor on the angstrom scale by trapping conformational states during activation with artificial metal ion binding sites and disulfide bonds. Trapped receptors will be examined using biochemical measures of subunit association, biophysical reports of receptor activity and by structural biology. The results we obtain will be useful to rationally interfere with excitatory synapses in the brain and may therefore help the development of therapies.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Jelena Baranovic, Andrew JR Plested Auxiliary subunits keep AMPA receptors compact during activation and desensitization published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.40548 |
eLife 7 | 2020-03-05 |
| 2016 |
Andrew J.R. Plested Single-Channel Recording of Ligand-Gated Ion Channels published pages: pdb.top087239, ISSN: 1559-6095, DOI: 10.1101/pdb.top087239 |
Cold Spring Harbor Protocols 2016/8 | 2019-06-06 |
| 2017 |
Hector Salazar, Clarissa Eibl, Miriam Chebli, Andrew Plested Mechanism of partial agonism in AMPA-type glutamate receptors published pages: 14327, ISSN: 2041-1723, DOI: 10.1038/ncomms14327 |
Nature Communications 8 | 2019-06-06 |
| 2016 |
Andrew J.R. Plested, Jelena Baranovic Single-Channel Recording of Glycine Receptors in Human Embryonic Kidney (HEK) Cells published pages: pdb.prot091652, ISSN: 1559-6095, DOI: 10.1101/pdb.prot091652 |
Cold Spring Harbor Protocols 2016/8 | 2019-06-06 |
| 2018 |
Alvin Yu, Héctor Salazar, Andrew J.R. Plested, Albert Y. Lau Neurotransmitter Funneling Optimizes Glutamate Receptor Kinetics published pages: 139-149.e4, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.11.024 |
Neuron 97/1 | 2019-06-06 |
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