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BAS-SBBT SIGNED

Bacterial Amyloid Secretion: Structural Biology and Biotechnology.

Total Cost €

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EC-Contrib. €

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Partnership

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 BAS-SBBT project word cloud

Explore the words cloud of the BAS-SBBT project. It provides you a very rough idea of what is the project "BAS-SBBT" about.

directed    bacteroidetes    harness    assembly    fiber    reconstitution    questions    temporally    biotechnological    fibers    fundamental    selective    amyloid    biology    interventions    insights    events    periplasm    minimal    biofilms    stage    coli    soluble    interdisciplinary    membrane    outer    sufficient    critical    specialised    proteobacteria    functionalized    bacterial    concerning    framework    mediated    alzheimer    structure    functional    proteins    surface    gained    misfolding    extracellular    peptide    carriers    polypeptides    molecular    aggregation    structurally    protein    structural    cell    amyloidogenic    nanowires    safe    transporter    accessory    formed    self    unlike    patterned    biofilm    disease    coordinate    intermediates    pellicle    unravel    assemble    secretion    diseases    deposition    parkinson    guidance    pathological    vitro    mechanistically    trap    matrix    curli    transport    thought    found    constitute    pro    subunits    biosynthesis    machinery   

Project "BAS-SBBT" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙989˙488 €
 EC max contribution 1˙989˙488 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 1˙989˙488.00

Map

 Project objective

Curli are functional amyloid fibers that constitute the major protein component of the extracellular matrix in pellicle biofilms formed by Bacteroidetes and Proteobacteria. Unlike the protein misfolding and aggregation events seen in pathological amyloid diseases such as Alzheimer’s and Parkinson’s disease, curli are the product of a dedicated protein secretion machinery. Curli formation requires a specialised and mechanistically unique transporter in the bacterial outer membrane, as well as two soluble accessory proteins thought to facilitate the safe guidance of the curli subunits across the periplasm and to coordinate their self-assembly at cell surface.

In this interdisciplinary research program we will study the structural and molecular biology of E. coli curli biosynthesis and address the fundamental questions concerning the molecular processes that allow the spatially and temporally controlled transport and deposition of these pro-amyloidogenic polypeptides. We will structurally unravel the secretion machinery, trap and analyse critical secretion intermediates and through in vitro reconstitution, assemble a minimal, self-sufficient peptide transport and fiber assembly system.

The new insights gained will set the stage for targeted interventions in curli -mediated biofilm formation and this research project will develop a new framework to harness the unique properties found in curli structure and biosynthesis for biotechnological applications as in patterned functionalized nanowires and directed, selective peptide carriers.

 Publications

year authors and title journal last update
List of publications.
2015 Nani Van Gerven, Roger D. Klein, Scott J. Hultgren, Han Remaut
Bacterial Amyloid Formation: Structural Insights into Curli Biogensis
published pages: 693-706, ISSN: 0966-842X, DOI: 10.1016/j.tim.2015.07.010
Trends in Microbiology 23/11 2019-06-07
2017 Mike Sleutel, Imke Van den Broeck, Nani Van Gerven, Cécile Feuillie, Wim Jonckheere, Claire Valotteau, Yves F Dufrêne, Han Remaut
Nucleation and growth of a bacterial functional amyloid at single-fiber resolution
published pages: 902-908, ISSN: 1552-4450, DOI: 10.1038/nchembio.2413
Nature Chemical Biology 13/8 2019-06-07

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