CARDI-ACHE SIGNED
The cardiovascular consequences of endurance exercise
Total Cost €
0EC-Contrib. €
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Project "CARDI-ACHE" data sheet
The following table provides information about the project.
| Coordinator |
LIVERPOOL JOHN MOORES UNIVERSITY
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 183˙454 € |
| EC max contribution | 183˙454 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-06-01 to 2017-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | LIVERPOOL JOHN MOORES UNIVERSITY | UK (LIVERPOOL) | coordinator | 183˙454.00 |
Map
Project objective
Problem: Exercise training represents an attractive and low-cost strategy to improve cardiovascular health. Recent studies, however, report novel evidence that endurance exercise can lead to potentially detrimental cardiac maladaptations. First, acute exercise-induced elevations in cardiac troponin (cTn) levels have been found, which typically reflect myocardial (micro-)damage and are predictive of future cardiovascular events and mortality. Secondly, myocardial fibrosis has been reported in 12–50% of individuals engaged in lifelong exercise training, reflecting scarring of cardiac tissue that is typically found in patients with cardiovascular diseases (CVD). These cardiac maladaptations are highly unexpected and largely unexplained in apparently healthy individuals.
CARDI-ACHE: Based on the latest scientific insights, the overall aim of this proposal is to elucidate the clinical importance of exercise-induced cTn elevations and myocardial fibrosis in endurance athletes. Better understanding of the clinical relevance of these adaptations is important to differentiate between the beneficial and the potentially harmful effects of exercise. Accordingly, I will study the following scientifically and clinically relevant questions: I. What is the prognostic value of exercise-induced cTn elevations? II. What are the functional consequences of myocardial fibrosis and are these mediated by lifelong physical activity? III. Do exercise-induced cTn elevations contribute to the development of myocardial fibrosis?
Relevance for science & candidate. With this project, I will use the most technologically advanced approaches and tools to understand the clinical relevance of potential cardiac maladaptations to exercise training. The studies are performed in a world-renowned research group which allows me to expand my expertise in exercise cardiology using state-of-the-art facilities.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Thijs M.H. Eijsvogels, Martijn F.H. Maessen Exercise for Coronary Heart Disease Patients published pages: 1701-1703, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2017.08.016 |
Journal of the American College of Cardiology 70/14 | 2019-06-17 |
| 2017 |
Martijn F.H. Maessen, Casper G. Schalkwijk, Rebecca J.H.M. Verheggen, Vincent L. Aengevaeren, Maria T.E. Hopman, Thijs M.H. Eijsvogels A comparison of dicarbonyl stress and advanced glycation endproducts in lifelong endurance athletes vs. sedentary controls published pages: 921-926, ISSN: 1440-2440, DOI: 10.1016/j.jsams.2017.03.011 |
Journal of Science and Medicine in Sport 20/10 | 2019-06-17 |
| 2016 |
Nathalie MM Benda, Maria TE Hopman, Arie PJ van Dijk, David Oxborough, Keith P George, Dick HJ Thijssen, Thijs MH Eijsvogels Impact of prolonged walking exercise on cardiac structure and function in cardiac patients versus healthy controls published pages: 1252-1260, ISSN: 2047-4873, DOI: 10.1177/2047487316631389 |
European Journal of Preventive Cardiology 23/12 | 2019-06-17 |
| 2017 |
Vincent L. Aengevaeren, Arend Mosterd, Thijs L. Braber, Niek H.J. Prakken, Pieter A. Doevendans, Diederick E. Grobbee, Paul D. Thompson, Thijs M.H. Eijsvogels, Birgitta K. Velthuis Relationship Between Lifelong Exercise Volume and Coronary Atherosclerosis in AthletesClinical Perspective published pages: 138-148, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.117.027834 |
Circulation 136/2 | 2019-06-17 |
| 2016 |
Vincent L. Aengevaeren, Maria T. E. Hopman, Thijs M. H. Eijsvogels Fitness and Coronary Artery Calcification published pages: 716, ISSN: 2168-6106, DOI: 10.1001/jamainternmed.2016.0898 |
JAMA Internal Medicine 176/5 | 2019-06-17 |
| 2017 |
Vincent L. Aengevaeren, Maria T.E. Hopman, Dick H.J. Thijssen, Roland R. van Kimmenade, Menko-Jan de Boer, Thijs M.H. Eijsvogels Endurance exercise-induced changes in BNP concentrations in cardiovascular patients versus healthy controls published pages: 430-435, ISSN: 0167-5273, DOI: 10.1016/j.ijcard.2016.11.016 |
International Journal of Cardiology 227 | 2019-06-17 |
| 2017 |
Martijn F.H. Maessen, Thijs M.H. Eijsvogels, Ayla Grotens, Maria T.E. Hopman, Dick H.J. Thijssen, Hendrik H.G. Hansen Feasibility and relevance of compound strain imaging in non-stenotic arteries: comparison between individuals with cardiovascular diseases and healthy controls published pages: , ISSN: 1476-7120, DOI: 10.1186/s12947-017-0104-9 |
Cardiovascular Ultrasound 15/1 | 2019-06-17 |
| 2016 |
Thijs M. H. Eijsvogels, Paul D. Thompson Exercise Intensity, Dose, and Cardiovascular Disease—Reply published pages: 1659, ISSN: 0098-7484, DOI: 10.1001/jama.2016.0312 |
JAMA 315/15 | 2019-06-17 |
| 2016 |
Freek R. van de Schoor, Vincent L. Aengevaeren, Maria T.E. Hopman, David L. Oxborough, Keith P. George, Paul D. Thompson, Thijs M.H. Eijsvogels Myocardial Fibrosis in Athletes published pages: 1617-1631, ISSN: 0025-6196, DOI: 10.1016/j.mayocp.2016.07.012 |
Mayo Clinic Proceedings 91/11 | 2019-06-17 |
| 2015 |
Martijn F.H. Maessen, Maria T.E. Hopman, André L.M. Verbeek, Thijs M.H. Eijsvogels Dose of Jogging published pages: 2672-2673, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2015.02.080 |
Journal of the American College of Cardiology 65/24 | 2019-06-17 |
| 2017 |
Esmée A. Bakker, Silvie Timmers, Maria T. E. Hopman, Paul D. Thompson, André L. M. Verbeek, Thijs M. H. Eijsvogels Association Between Statin Use and Prevalence of Exercise-Related Injuries: A Cross-Sectional Survey of Amateur Runners in the Netherlands published pages: 1885-1892, ISSN: 0112-1642, DOI: 10.1007/s40279-017-0681-7 |
Sports Medicine 47/9 | 2019-06-17 |
| 2017 |
Thijs M. Eijsvogels, Paul D. Thompson Are There Clinical Cardiac Complications From Too Much Exercise? published pages: 9-11, ISSN: 1537-890X, DOI: 10.1249/JSR.0000000000000322 |
Current Sports Medicine Reports 16/1 | 2019-06-17 |
| 2016 |
Martijn F.H. Maessen, André L.M. Verbeek, Esmée A. Bakker, Paul D. Thompson, Maria T.E. Hopman, Thijs M.H. Eijsvogels Lifelong Exercise Patterns and Cardiovascular Health published pages: 745-754, ISSN: 0025-6196, DOI: 10.1016/j.mayocp.2016.02.028 |
Mayo Clinic Proceedings 91/6 | 2019-06-17 |
| 2016 |
Paul D. Thompson, Silvana Molossi, Duck-chul Lee, Michael S. Emery, Thijs M.H. Eijsvogels Reply published pages: 2911, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2016.03.574 |
Journal of the American College of Cardiology 67/24 | 2019-06-17 |
| 2017 |
MARTIJN F. H. MAESSEN, THIJS M. H. EIJSVOGELS, BREGINA T. P. HIJMANS-KERSTEN, AYLA GROTENS, TIM H. A. SCHREUDER, MARIA T. E. HOPMAN, DICK H. J. THIJSSEN Vascular Function and Structure in Veteran Athletes after Myocardial Infarction published pages: 21-28, ISSN: 0195-9131, DOI: 10.1249/MSS.0000000000001075 |
Medicine & Science in Sports & Exercise 49/1 | 2019-06-17 |
| 2017 |
Esmée A. Bakker, Duck-chul Lee, Xuemei Sui, Enrique G. Artero, Jonatan R. Ruiz, Thijs M.H. Eijsvogels, Carl J. Lavie, Steven N. Blair Association of Resistance Exercise, Independent of and Combined With Aerobic Exercise, With the Incidence of Metabolic Syndrome published pages: 1214-1222, ISSN: 0025-6196, DOI: 10.1016/j.mayocp.2017.02.018 |
Mayo Clinic Proceedings 92/8 | 2019-06-17 |
| 2017 |
Martijn F. H. Maessen, Anke C. C. M. van Mil, Yaïra Straathof, Niels P. Riksen, Gerard A. P. J. M. Rongen, Maria T. E. Hopman, Thijs M. H. Eijsvogels, Dick H. J. Thijssen Impact of lifelong exercise training on endothelial ischemia-reperfusion and ischemic preconditioning in humans published pages: R828-R834, ISSN: 0363-6119, DOI: 10.1152/ajpregu.00466.2016 |
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 312/5 | 2019-06-17 |
| 2018 |
Esmée A. Bakker, Johan A. Snoek, Esther P. Meindersma, Maria T.E. Hopman, Louise Bellersen, André L.M. Verbeek, Dick H.J. Thijssen, Thijs M.H. Eijsvogels Absence of Fitness Improvement Is Associated with Outcomes in Heart Failure Patients published pages: 1, ISSN: 0195-9131, DOI: 10.1249/MSS.0000000000001429 |
Medicine & Science in Sports & Exercise | 2019-06-17 |
| 2016 |
Thijs M.H. Eijsvogels, Silvana Molossi, Duck-chul Lee, Michael S. Emery, Paul D. Thompson Exercise at the Extremes published pages: 316-329, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2015.11.034 |
Journal of the American College of Cardiology 67/3 | 2019-06-17 |
| 2017 |
Thijs M. H. Eijsvogels, David L. Oxborough, Rory O’Hanlon, Sanjay Sharma, Sanjay Prasad, Greg Whyte, Keith P. George, Mathew G. Wilson Global and regional cardiac function in lifelong endurance athletes with and without myocardial fibrosis published pages: 1297-1303, ISSN: 1746-1391, DOI: 10.1080/17461391.2017.1373864 |
European Journal of Sport Science 17/10 | 2019-06-17 |
| 2016 |
Thijs M.H. Eijsvogels, Keith P. George, Paul D. Thompson Cardiovascular benefits and risks across the physical activity continuum published pages: 566-571, ISSN: 0268-4705, DOI: 10.1097/HCO.0000000000000321 |
Current Opinion in Cardiology 31/5 | 2019-06-17 |
| 2017 |
Martijn FH Maessen, Thijs MH Eijsvogels, Guus Stevens, Arie PJ van Dijk, Maria TE Hopman Benefits of lifelong exercise training on left ventricular function after myocardial infarction published pages: 1856-1866, ISSN: 2047-4873, DOI: 10.1177/2047487317728765 |
European Journal of Preventive Cardiology 24/17 | 2019-06-17 |
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