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GutILC3

Cell-cell interactions critical to ILC3 function in the human gut

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Outcomes and results

 GutILC3 project word cloud

Explore the words cloud of the GutILC3 project. It provides you a very rough idea of what is the project "GutILC3" about.

prospects    model    therapies    modulating    mouse    critical    unknown    me    ibd    group    record    discovered    conferring    optimal    etiology    il    ensures    excellent    inappropriate    ilcs    career    dramatically    producing    22    manner    skill    extensive    ultimate    molecules    therapy    lymphoid    17    genetically    infrastructure    reporting    feasibility    mucosal    ilc3    suitable    microbes    cancer    homeostasis    track    possibilities    players    risk    inflammation    gamma    intestine    cellular    colitis    phagocytes    cd4    truly    seem    interestingly    disease    intestinal    inflammatory    interacting    degree    papers    susceptible    translational    interactions    insights    innate    provides    utilizes    society    exact    materials    purpose    techniques    hosting    cells    patient    crosstalk    building    colorectal    unravel    mononuclear    interaction    progression    host    maintaining    monitoring    immune    training    bowel    crc    direct    ifn    human    pinpoint   

Project "GutILC3" data sheet

The following table provides information about the project.

Coordinator		 KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Sweden [SE]
 Total cost 173˙857 €
 EC max contribution 173˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 173˙857.00

Map

 Project objective

Inflammatory bowel disease (IBD), conferring a dramatically increased risk for development of colorectal cancer (CRC), results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. However, the exact etiology of IBD is unknown. Building up on high impact papers from the host group reporting on the recently discovered innate lymphoid cells (ILCs) as key players in mucosal inflammation, I now aim to unravel the role for ILCs in IBD and CRC. Interestingly, while the IL-22 producing ILC3 seem to be crucial in maintaining intestinal homeostasis, the IL-17 and IFN-gamma-producing ILCs can cause inflammation in a mouse model of colitis and are present in human IBD. Furthermore, ILCs were recently described to be involved in modulating immune responses, by interacting with CD4 T cells and mononuclear phagocytes in the mouse intestine. I aim to identify critical pathways in the crosstalk of ILC3 with other immune cells in the human intestine. The ultimate purpose is to assess how these interactions affect immune homeostasis and disease progression in IBD and CRC. We will pinpoint crucial interaction molecules and cellular processes that can be used for monitoring current therapies as well as finding new therapy targets for IBD and CRC. This truly translational proposal utilizes, in an optimal manner, unique state-of-the-art techniques and patient materials to provide novel insights into the etiology of IBD and CRC. The excellent track record of the hosting group, the highly suitable infrastructure provided by the host institution and my own extensive research experience ensures a high degree of feasibility. Furthermore, this project provides excellent training opportunities, skill advancement possibilities and career prospects for me and its results are expected to have a direct impact on the European society.

 Publications

year authors and title journal last update
List of publications.
2015 V. Konya, J. Mjösberg
Innate Lymphoid Cells in Graft-Versus-Host Disease
published pages: 2795-2801, ISSN: 1600-6135, DOI: 10.1111/ajt.13394 		American Journal of Transplantation 15/11 2019-07-23
2016 Åsa K Björklund, Marianne Forkel, Simone Picelli, Viktoria Konya, Jakob Theorell, Danielle Friberg, Rickard Sandberg, Jenny Mjösberg
The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing
published pages: 451-460, ISSN: 1529-2908, DOI: 10.1038/ni.3368 		Nature Immunology 17/4 2019-07-23
2016 Viktoria Konya, Jenny Mjösberg
Lipid mediators as regulators of human ILC2 function in allergic diseases
published pages: 36-42, ISSN: 0165-2478, DOI: 10.1016/j.imlet.2016.07.006 		Immunology Letters 179 2019-07-23

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