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APGAR

Air Pollution, Growing brAin and cognitive disordeR in children

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

APGAR project word cloud

Explore the words cloud of the APGAR project. It provides you a very rough idea of what is the project "APGAR" about.

disease recovery original apgar innovative disorder weighted link cognitive supervised adverse actions quality functional public air secondly imaging spin epidemiology sequences environmental statistical spectrometry weekly resonance machine psychometric functions 2012 correlated 2013 models interfacing multidisciplinary mechanisms on diffusion attenuation images six reduce week cognition structural structures resolution burden spain pollution exposure regression underlie combination 400 brain performance health exclusively urban dimensional barcelona later neuroimaging inversion profiles echo learning school fluid mri months t2 population periods magnetic unknown children recruited age examine tensor beginning schools scores longitudinal

Project "APGAR" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL There are not information about this coordinator. Please contact Fabio for more information, thanks.
Coordinator Country	Spain [ES]
Project website	https://www.isglobal.org/en/-/air-pollution-growing-brain-and-cognitive-disorder-in-children-apgar-proyecto-inma
Total cost	170˙121 €
EC max contribution	170˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-10-15 to 2017-10-14

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA Organization address address: C ROSSELLO 132 PLANTA 05 city: BARCELONA postcode: 8036 website: www.isglobal.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	170˙121.00
2	FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL Organization address address: Calle Doctor Aiguader 88 city: BARCELONA postcode: 8003 website: www.creal.cat contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	0.00

Map

Project objective

Air pollution exposure has been associated with adverse effects on cognition in children. However, the impact of air pollution on the structures and functions of the growing brain in children is unknown. The objectives of the APGAR project are to determine 1) the impact of urban air pollution on the structures and functions of the growing brain in children from the general population, 2) to what extent these structural and functional changes are associated with cognitive performance in children. The APGAR project is a longitudinal study conducted in 400 school age children from the general population, recruited between 2012 and 2013, in different schools in Barcelona, Spain. Psychometric and air pollution measurements were conducted weekly during 2 six-week periods: at the beginning of the school year and 9 months later. Neuroimaging (High-resolution 3-dimensional Magnetic Resonance Imaging (MRI), Diffusion Tensor Images, Fluid Attenuation Inversion Recovery, T2-weighted spin-echo sequences and functional MRI, spectrometry) were also conducted. Interfacing neuroimaging and environmental epidemiology represents an innovative applications of neuroimaging in general population, as previous studies have focused exclusively on effects based on test scores. Using original statistical methods (combination of supervised machine learning methods, feature selection and regression models), we will examine the impact of air pollution on the brain structures correlated with cognitive performance in children. Secondly, we will examine whether profiles of brain changes, specifically related to air pollution exposure, are associated with cognition level in participants. This multidisciplinary project may improve our understanding of the mechanisms that underlie the link between air pollution and cognitive disorder in children, and may lead to public health actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.

Publications

List of publications.
year	authors and title	journal	last update
2017	Marion Mortamais, Jesus Pujol, Barend L. van Drooge, Didac Maci?, Gerard Mart?nez-Vilavella, Christelle Reynes, Robert Sabatier, Ioar Rivas, Joan Grimalt, Joan Forns, Mar Alvarez-Pedrerol, Xavier Querol, Jordi Sunyer Effect of exposure to polycyclic aromatic hydrocarbons on basal ganglia and attention-deficit hyperactivity disorder symptoms in primary school children published pages: 12-19, ISSN: 0160-4120, DOI: 10.1016/j.envint.2017.04.011	Environment International 105	2019-06-13

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The information about "APGAR" are provided by the European Opendata Portal: CORDIS opendata.