membrane-ezrin-actin
Membrane-ezrin-actin interactions mediated by ezrin binding proteins in reconstituted systems
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0membrane-ezrin-actin project word cloud
Explore the words cloud of the membrane-ezrin-actin project. It provides you a very rough idea of what is the project "membrane-ezrin-actin" about.
Project "membrane-ezrin-actin" data sheet
The following table provides information about the project.
| Coordinator |
INSTITUT CURIE
Organization address contact info |
| Coordinator Country | France [FR] |
| Project website | https://science.institut-curie.org/research/multiscale-physics-biology-chemistry/umr168-physical-chemistry/team-bassereau/ |
| Total cost | 173˙076 € |
| EC max contribution | 173˙076 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-01-01 to 2017-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INSTITUT CURIE | FR (PARIS) | coordinator | 173˙076.00 |
Map
Project objective
Microvilli are tube-like membrane protrusions containing bundles of actin filaments located at the apical surface of epithelial cells. A key component of these microvilli is ezrin, a member of the Ezrin/Radixin/Moesin protein family, which provides a regulated linkage between the plasma membrane and the actin cytoskeleton. The critical role of ezrin in microvillar morphogenesis has been demonstrated. However, how ezrin is recruited to the apical surface of the cells and how ezrin contributes to the stability of microvillar morphogenesis remain elusive. Recently, a few ezrin binding partners, such as EBP50 and Eps8, have been identified and shown to function synergistically with ezrin in membrane and actin remodelling in cells. The precise mechanisms and implications of their interactions in microvillar morphogenesis are not well understood. Lately, I-BAR domain protein IRSp53 was found to colocalize with ezrin in microvilli and interact with both EBP50 and Eps8, as ezrin does. Given that I-BAR domain proteins participate in the formation of many cellular protrusions, such as filopodia, ezrin and I-BAR domain proteins may work synergistically in membrane remodelling.
The goal of this proposal is to better understand the interaction of ezrin, the membrane and actin, and the role of ezrin binding proteins and I-BAR domain proteins in this interaction by using reconstituted model systems based on purified proteins combined with supported lipid bilayers or giant unilamellar vesicles. In parallel, potential common binding partners of ezrin and I-BAR domain proteins will be identified, and their role in mediating the interaction of ezrin and I-BAR domain proteins on membranes will be studied. This project will thus lead to an improved understanding of the membrane and actin remodelling activity of ezrin, and advance our knowledge of cell and eventually tissue morphogenesis.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MEMBRANE-EZRIN-ACTIN" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "MEMBRANE-EZRIN-ACTIN" are provided by the European Opendata Portal: CORDIS opendata.