Opendata, web and dolomites

DETRIMODE SIGNED

DEgradation TRIggered by MOdular DEsign

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 DETRIMODE project word cloud

Explore the words cloud of the DETRIMODE project. It provides you a very rough idea of what is the project "DETRIMODE" about.

society    mutual    structural    biology    public    peers    driving    chance    e3    computational    stages    ubiquitinating    affinity    latter    influenced    tpdi    innovation    modular    ubiquitin    bifunctional    nms    comprised    chemical    synthesis    incrementing    ec    progressively    inducers    core    scope    synthetic    closer    composition    prospects    organic    length    grafted    molecular    flexibility    multidisciplinary    combinable    tripartite    proteasome    chemistry    competence    ligands    recruitment    cell    outcomes    series    ligase    progresses    apt    designed    ternary    intermediates    grow    purinome    molecules    engaged    joined    endeavour    tackles    disease    articulated    degradationtriggered    medchem    pursued    molecule    drugs    solid    proximity    company    efficiency    variety    entities    updates    proteins    methodology    linker    science    exploited    environment    protein    shared    arrays    speed    tpdis    technologies    dept    researcher    therapeutic    communicated    close    small    protected    spacer    discovery    oncology    detrimode    degradation    ligand   

Project "DETRIMODE" data sheet

The following table provides information about the project.

Coordinator
NERVIANO MEDICAL SCIENCES S.R.L 

Organization address
address: VIALE LUIGI PASTEUR 10
city: NERVIANO
postcode: 20014
website: www.nervianoms.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-05-21   to  2020-07-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NERVIANO MEDICAL SCIENCES S.R.L IT (NERVIANO) coordinator 168˙277.00

Map

 Project objective

The project DETRIMODE (DEgradationTRIggered by MOdular Design) aims at the development of a methodology for the modular synthesis of Targeted Protein Degradation Inducers (TPDI), designed as bifunctional molecules apt to the degradation of target proteins via recruitment of the ubiquitin proteasome system, a process with therapeutic prospects if applied to disease driving proteins. TPDIs are comprised of an E3 ligase ligand and a target protein ligand joined by a spacer (linker), to bring the ubiquitinating system and the target protein in close proximity, so to promote degradation of the latter. The formation of the ternary complex (target protein-TPDI-E3 ligase) is an articulated process influenced by a series of factors, such as ligands affinity, linker length and composition and molecular features of the proteins involved. The project tackles this endeavour in stages of increasing innovation, progressively incrementing the scope, flexibility and efficiency of modular synthetic access to arrays of tripartite molecules via protected, solid grafted intermediates, combinable with a variety of target ligands. New chemical entities TPDIs will be generated targeting selected purinome proteins oncology-related. This project will be pursued within the Chemical Core Technologies Dept. of a fully integrated company (NMS), engaged in the discovery and development of new small molecule based drugs. Organic and solid phase chemistry, computational and structural chemistry, molecular and cell biology, among others, will be exploited to achieve the project’s goal. In such multidisciplinary environment, this new technology will grow at the same speed with the researcher’s medchem competence, increasing the chance of mutual success. DETRIMODE outcomes will be shared with peers, while updates on its progresses as well as general information on how EC-funded research have impact on the general public will be communicated by a number of means, bringing science closer to society

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DETRIMODE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DETRIMODE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

OSeaIce (2019)

Two-way interactions between ocean heat transport and Arctic sea ice

Read More  

ACES (2019)

Antarctic Cyclones: Expression in Sea Ice

Read More  

FarGo (2019)

'Farming God's Way': Cultivation and religious practice in contemporary South Africa

Read More