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DETRIMODE SIGNED

DEgradation TRIggered by MOdular DEsign

Total Cost €

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EC-Contrib. €

0

Partnership

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 DETRIMODE project word cloud

Explore the words cloud of the DETRIMODE project. It provides you a very rough idea of what is the project "DETRIMODE" about.

progresses    molecule    e3    proteasome    articulated    proximity    stages    methodology    chance    chemical    endeavour    small    environment    technologies    closer    dept    ligase    ternary    progressively    grafted    peers    exploited    science    ubiquitin    combinable    intermediates    grow    arrays    comprised    flexibility    joined    molecules    biology    disease    core    latter    synthetic    therapeutic    ligands    detrimode    communicated    updates    bifunctional    driving    outcomes    tripartite    engaged    cell    tpdis    computational    multidisciplinary    series    degradationtriggered    ec    tpdi    designed    influenced    pursued    ligand    length    apt    protected    drugs    competence    recruitment    company    purinome    prospects    researcher    entities    chemistry    modular    tackles    protein    close    ubiquitinating    organic    spacer    solid    variety    degradation    proteins    structural    oncology    medchem    society    nms    incrementing    shared    innovation    inducers    efficiency    molecular    discovery    linker    composition    synthesis    scope    public    speed    affinity    mutual   

Project "DETRIMODE" data sheet

The following table provides information about the project.

Coordinator
NERVIANO MEDICAL SCIENCES S.R.L 

Organization address
address: VIALE LUIGI PASTEUR 10
city: NERVIANO
postcode: 20014
website: www.nervianoms.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-05-21   to  2020-07-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NERVIANO MEDICAL SCIENCES S.R.L IT (NERVIANO) coordinator 168˙277.00

Map

 Project objective

The project DETRIMODE (DEgradationTRIggered by MOdular Design) aims at the development of a methodology for the modular synthesis of Targeted Protein Degradation Inducers (TPDI), designed as bifunctional molecules apt to the degradation of target proteins via recruitment of the ubiquitin proteasome system, a process with therapeutic prospects if applied to disease driving proteins. TPDIs are comprised of an E3 ligase ligand and a target protein ligand joined by a spacer (linker), to bring the ubiquitinating system and the target protein in close proximity, so to promote degradation of the latter. The formation of the ternary complex (target protein-TPDI-E3 ligase) is an articulated process influenced by a series of factors, such as ligands affinity, linker length and composition and molecular features of the proteins involved. The project tackles this endeavour in stages of increasing innovation, progressively incrementing the scope, flexibility and efficiency of modular synthetic access to arrays of tripartite molecules via protected, solid grafted intermediates, combinable with a variety of target ligands. New chemical entities TPDIs will be generated targeting selected purinome proteins oncology-related. This project will be pursued within the Chemical Core Technologies Dept. of a fully integrated company (NMS), engaged in the discovery and development of new small molecule based drugs. Organic and solid phase chemistry, computational and structural chemistry, molecular and cell biology, among others, will be exploited to achieve the project’s goal. In such multidisciplinary environment, this new technology will grow at the same speed with the researcher’s medchem competence, increasing the chance of mutual success. DETRIMODE outcomes will be shared with peers, while updates on its progresses as well as general information on how EC-funded research have impact on the general public will be communicated by a number of means, bringing science closer to society

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The information about "DETRIMODE" are provided by the European Opendata Portal: CORDIS opendata.

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