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MagProtoCell

Magnetic micromachines based on protocell design and engineering

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 MagProtoCell project word cloud

Explore the words cloud of the MagProtoCell project. It provides you a very rough idea of what is the project "MagProtoCell" about.

group    expertise    drug    locations    selective    fluidic    ways    enhanced    noncontact    levels    chemicals    of    materials    chemical    engineering    strategic    edge    synthetic    metabolism    composition    bristol    temporal    construction    responsive    regard    made    clinical    concentrations    sense    disposition    local    life    mf    biomimetic    cellular    earth    thereby    remote    environments    last    progress    prof    micromachines    protocell    frs    university    employing    mann    functions    class    multidisciplinary    forces    magnetic    inclusion    surrounding    stimuli    encapsulation    rodr    exhibiting    stone    leadership    methodology    stepping    dr    external    cutting    sensing    clean    iacute    alternative    mfs    arco    date    guez    particles    chemotaxis    few    motility    involve    outcome    environment    couple    bioreactor    stimulate    directed    colloidal    replication    protocells    spatial    hosting    machines    construct    origin    exchange    lifelike    medium    artificial    movement    diagnosis   

Project "MagProtoCell" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.bristol.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

Protocells are artificial cellular systems exhibiting lifelike properties, which are proposed as a stepping-stone for understanding the origin of life on Earth. Features such as encapsulation, replication, metabolism and selective exchange of chemicals with the environment will enable their use as micromachines in a number of emerging applications (e.g., environment clean-up, clinical diagnosis, drug delivery, remote sensing, bioreactor technology). However, progress in such applications will be enhanced by the synthetic construction of protocells capable of directed movement in fluidic environments in response to external stimuli. To date, motility has been achieved only in a few cases, which involve a response to changes in chemical concentrations (chemotaxis) in the surrounding medium. However, controlling the chemical composition of the local environment is challenging, and thus alternative ways to stimulate motility are needed. In this regard, external magnetic fields (MFs) will enable high levels of control of protocell motility and spatial disposition to be achieved by employing noncontact forces. This is the aim of this proposal: to design and construct synthetic protocells able to sense and respond to external MFs. A key outcome of the work will be the development of a new class of magnetic micromachines based on protocell design and engineering. Such machines will couple MF-directed motility with the temporal and spatial delivery of advanced biomimetic functions. The key factor of the proposed methodology is the inclusion of colloidal magnetic particles at strategic locations in the protocell composition or in the external medium. Thereby, the expertise of the applicant (Dr. Rodríguez Arco) in the field of MF-responsive materials will be applied to the multidisciplinary and cutting-edge field of protocells in which the hosting group at the University of Bristol (under the leadership of Prof. Mann FRS) has made great progress in the last few years.

 Publications

year authors and title journal last update
List of publications.
2017 Laura Rodriguez-Arco, Mei Li, Stephen Mann
Phagocytosis-inspired behaviour in synthetic protocell communities of compartmentalized colloidal objects
published pages: TBC, ISSN: 1476-1122, DOI: 10.1038/nmat4916
Nature Materials TBC 2019-07-22

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The information about "MAGPROTOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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