Explore the words cloud of the INSCAPE project. It provides you a very rough idea of what is the project "INSCAPE" about.
The following table provides information about the project.
Coordinator |
KLINIKUM DER UNIVERSITAET ZU KOELN
Organization address contact info |
Coordinator Country | Germany [DE] |
Total cost | 239˙860 € |
EC max contribution | 239˙860 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2014 |
Funding Scheme | MSCA-IF-GF |
Starting year | 2015 |
Duration (year-month-day) | from 2015-05-15 to 2018-05-14 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | KLINIKUM DER UNIVERSITAET ZU KOELN | DE (KOELN) | coordinator | 239˙860.00 |
2 | BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | US (STANFORD) | partner | 0.00 |
Voltage gated sodium channels (NaVs) are the primary transmembrane proteins underlying fast electrical communication in neurons of the peripheral and central nervous system (PNS and CNS). Being such an integral part of neuronal signaling, they are implicated in a number of severe diseases that have a major impact on human society. However, drugs and established therapies targeting NaVs are rare due to common off-target effects. Therefore, new NaV-blockers will be developed and used for in vivo imaging using positron emission tomography (PET). For this purpose, novel derivatives of the recently disclosed truncated batrachotoxin (tr-BTX), which represent a completely new type of NaV-blockers, will be synthesized and their ability to block different NaV isoforms (NaV1.1 to 1.8) will be tested using fluorescent assays. The most promising candidates will then be labeled using different positron emitting isotopes such as carbon-11 (11C) and fluorine-18 (18F) exploiting different radioactive half-lifes and metabolic stability. The resulting “hot-tr-BTX” will be subsequently employed in small rodent PET-scans revealing their in vivo pharmacokinetics. This novel and unique tool will provide three major immediate benefits. First, hot-tr-BTX might deliver a general imaging probe for nervous activity in the PNS, and potentially the CNS, by monitoring NaV function in vivo. Secondly, this will allow the investigation of various pain conditions and neurodegenerative diseases and link their pathogenesis to NaV-function. Thirdly, the proposed research might deliver not only new NaV-blockers as potential drug candidates, but will also provide a valuable method facilitating the development of long awaited drugs targeting NaVs for pain therapy, a goal that is currently intensely investigated by numerous European and global pharmaceutical companies.
year | authors and title | journal | last update |
---|---|---|---|
2017 |
Matthias Schoenberger
, Jacob Hooker
, Martin Strebl
, Al Schroeder
, Timothy McKinsey
, and Amrut Ambardekar Imaging cardiac voltage gated sodium channels using the novel F-18 radiotracer radiocaine published pages: , ISSN: , DOI: |
2019-06-13 | |
2017 |
Matthias Schoenberger, Frederick A. Schroeder, Michael S. Placzek, Randall L. Carter, Bruce R. Rosen, Jacob M. Hooker, Christin Y. Sander In Vivo [ 18 F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates published pages: 298-305, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.7b00327 |
ACS Chemical Neuroscience 9/2 | 2019-06-13 |
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The information about "INSCAPE" are provided by the European Opendata Portal: CORDIS opendata.
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