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Molmechindividuality

Molecular mechanisms of neuronal connectivity - the synaptic code for variability and stereotypy

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Molmechindividuality project word cloud

Explore the words cloud of the Molmechindividuality project. It provides you a very rough idea of what is the project "Molmechindividuality" about.

electrophysiological comprised drosophila questions screen billions neural genes brain connectivity events correlate morphological tackle question emerges forming individuals suited alter nevertheless crucially promotes correlating stereotyped neurons variations organization functions shaping shape specificity wiring series subset first deterministic behavioural perspective synaptic variability perform behaviour behaviourally developmental elusive modify fly answer circuit parallel circuitry olfactory network appropriate chosen correct interplay acquires levels regions

Project "Molmechindividuality" data sheet

The following table provides information about the project.

Coordinator	FREIE UNIVERSITAET BERLIN Organization address address: KAISERSWERTHER STRASSE 16-18 city: BERLIN postcode: 14195 website: www.fu-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://www.hassanlab.eu/
Total cost	171˙684 €
EC max contribution	171˙684 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-09-01 to 2018-11-01

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FREIE UNIVERSITAET BERLIN FREIE UNIVERSITAET BERLIN Organization address address: KAISERSWERTHER STRASSE 16-18 city: BERLIN postcode: 14195 website: www.fu-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	coordinator	142˙884.00
2	VIB VIB Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	participant	28˙800.00

Map

Project objective

Behaviour emerges from an interplay of various brain regions and billions of neurons forming a network. The brain acquires its organization by a series of developmental events. The correct wiring of the brain is crucially important for all brain functions. Nevertheless, the brain is both stereotyped and variable across individuals. Currently only a subset of genes have been identified that shape specificity in connectivity and it is highly elusive what promotes variability in synaptic connectivity and whether this is behaviourally relevant. To work on these questions I have chosen the Drosophila olfactory system, which is well-defined both on the levels of circuitry and behaviour and as such well-suited to answer these question. Furthermore, from the perspective of circuitry, it is particularly appropriate as it is comprised of both deterministic and non-deterministic synaptic connectivity. In a first step to tackle the question, I will perform a screen to identify genes shaping deterministic and non-deterministic neural connectivity. In parallel, I will investigate olfactory behavioural variability in the fly and correlate this to circuitry variations on the morphological, synaptic and electrophysiological level. After identifying genes that are important for connectivity and correlating circuit to behavioural variability, I aim to modify circuit variability to alter behaviour.

Publications

List of publications.
year	authors and title	journal	last update
2018	Guangda Liu, Tanmay Nath, Gerit A. Linneweber, Annelies Claeys, Zhengyu Guo, Jin Li, Mercedes Bengochea, Steve De Backer, Barbara Weyn, Manu Sneyders, Hans Nicasy, Peng Yu, Paul Scheunders, Bassem A. Hassan A simple computer vision pipeline reveals the effects of isolation on social interaction dynamics in Drosophila published pages: e1006410, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006410	PLOS Computational Biology 14/8	2019-05-22
2017	Luis M. Franco, Zeynep Okray, Gerit A. Linneweber, Bassem A. Hassan, Emre Yaksi Reduced Lateral Inhibition Impairs Olfactory Computations and Behaviors in a Drosophila Model of Fragile X Syndrome published pages: 1111-1123, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.02.065	Current Biology 27/8	2019-05-22

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