BIOeSPUN scaffolds
Bioactive glass in electrospun matrices: functionalised smart scaffolds for interface tissue engineering applications
Total Cost €
0EC-Contrib. €
0Partnership
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Project "BIOeSPUN scaffolds" data sheet
The following table provides information about the project.
| Coordinator |
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | http://www.biomat.techfak.uni-erlangen.de/mitarbeiter/bio-materialien/liliana-liverani.shtml |
| Total cost | 159˙460 € |
| EC max contribution | 159˙460 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-06-01 to 2017-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG | DE (ERLANGEN) | coordinator | 159˙460.00 |
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Project objective
The project aims to fabricate and characterise novel type of multilayered scaffolds suitable for interface tissue engineering applications, in particular for osteochondral segment regeneration. Osteochondral defects imply injury in cartilage, bone and bone-cartilage interface tissues, characteristic of all the joints of human body, its causes could be both traumatic and due to aging-related pathologies. The project will be focused on the integration of several scaffold fabrication techniques for the development of novel electrospun multilayered scaffolds. In particular, considering the well-known effects of bioactive glass on osteogenesis, angiogenesis and its antibacterial activity, electrospun bioactive glass mats will be fabricated. Moreover, bioactive glass particles will be dispersed in a polymeric solution before the electrospinning for the fabrication of bioactive glass-doped mats. These two kind of scaffold will be used for the fabrication of the multilayered structures. Innovative solutions will be adopted for the obtainment of the stratified samples, integrating different technologies as the electrospinning, freeze-drying and foam replica method. The training of the researcher in the host Institution will be focus on the development of skills related to cell culture management and in particular on cell culture for tissue engineering. The training will start with cell viability tests and cell seeding on several kind of scaffolds. Several cell lines will be used and it will be also investigated stem cells differentiation. The use of co-culture systems and dynamic cell culture will also be evaluated and eventually applied to the multilayered scaffolds. An innovative approach will be used in the investigation of scaffold mechanical properties, in fact mechanical tests will be performed on the multilayered samples and on each single layer to evaluate the deposition of ECM on the seeded scaffolds and how it affects scaffold mechanical properties.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
Liverani Liliana, Boccaccini Aldo Electrospinning with benign solvents: feasibility study and versatile use of poly(epsilon-caprolactone) fibers published pages: , ISSN: 2296-4185, DOI: 10.3389/conf.FBIOE.2016.01.01826 |
Frontiers in Bioengineering and Biotechnology 4 | 2019-07-23 |
| 2017 |
L. Liverani, J.A. Roether, A.R. Boccaccini Nanofiber composites in bone tissue engineering. In: Nanofiber Composite Materials for Biomedical Applications edited by Murugan Ramalingam and Seeram Ramakrishna. published pages: 301-323, ISSN: , DOI: 10.1016/B978-0-08-100173-8.00012-0 |
2019-07-23 | |
| 2016 |
Liliana Liverani, Aldo Boccaccini Versatile Production of Poly(Epsilon-Caprolactone) Fibers by Electrospinning Using Benign Solvents published pages: 75, ISSN: 2079-4991, DOI: 10.3390/nano6040075 |
Nanomaterials 6/4 | 2019-07-23 |
| 2016 |
William C. Lepry, Sophia Smith, Liliana Liverani, Aldo R. Boccaccini, Showan N. Nazhat Acellular Bioactivity of Sol-Gel Derived Borate Glass-Polycaprolactone Electrospun Scaffolds published pages: , ISSN: 2299-3932, DOI: 10.1515/bglass-2016-0011 |
Biomedical glasses 2/1 | 2019-07-23 |
| 2017 |
Liliana Liverani, Jonas Lacina, Judith A. Roether, Elena Boccardi, Manuela S. Killian, Patrik Schmuki, Dirk W. Schubert, Aldo R. Boccaccini Incorporation of bioactive glass nanoparticles in electrospun PCL/chitosan fibers by using benign solvents published pages: , ISSN: 2452-199X, DOI: 10.1016/j.bioactmat.2017.05.003 |
Bioactive Materials | 2019-07-23 |
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