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SECOMAP

Sexual Commitment of Malaria Parasites: Investigation Into the Epigenetic Control of Plasmodium Gametocytogenesis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SECOMAP project word cloud

Explore the words cloud of the SECOMAP project. It provides you a very rough idea of what is the project "SECOMAP" about.

transmission regulate light forms ap2 details parasites gametocyte gene unknown formerly therapeutic controls enduring suitably largely unicellular replication commitment time infectious molecular genus intervention prolonged organisms gametocytogenesis mosquitoes replicate exclusively malaria infect epigenetic mosquito repression switch gametocytes master regulated almost transmitted sexual threats rodents host humans mechanisms shed plasmodium locus expression instead vector regulator asexually human infection elucidate asexual implications caused transcription worldwide routes activation intends health dead

Project "SECOMAP" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.gla.ac.uk/researchinstitutes/iii/staff/andywaters/
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-08-01 to 2017-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	coordinator	195˙454.00

Map

Project objective

Malaria is one of the major threats for human health worldwide and caused by unicellular organisms of the Plasmodium genus. Within their mosquito vector and human host malaria parasites replicate almost exclusively asexually. In order to be transmitted to mosquitoes formerly asexual parasites instead develop into gametocytes, which are the only forms that can infect mosquitoes. Understanding the switch of asexual to sexual replication could offer new routes towards therapeutic intervention in sexual development and transmission. However, the molecular details of commitment to gametocytogenesis remain largely unknown, and only recently the AP2-G transcription factor was identified as master regulator of gametocytogenesis. Gametocyte formation is a dead end for enduring infection and therefore sexual commitment has to be suitably regulated to ensure prolonged infection and transmission at the same time. The proposed research project aims to elucidate the epigenetic mechanisms which controls gametocytogenesis in malaria parasites infectious to rodents and humans, and intends to identify key molecular factors which regulate repression and activation of the ap2-g locus. The project will shed new light on the molecular mechanisms controlling sexual commitment and general gene expression in Plasmodium, with implications for therapeutic intervention in transmission and development of malaria parasites.

Publications

List of publications.
year	authors and title	journal	last update
2016	Sebastian Kirchner, B. Joanne Power, Andrew P. Waters Recent advances in malaria genomics and epigenomics published pages: , ISSN: 1756-994X, DOI: 10.1186/s13073-016-0343-7	Genome Medicine 8/1	2019-07-24

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The information about "SECOMAP" are provided by the European Opendata Portal: CORDIS opendata.